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Sensitivity analysis is an important part of a mathematical modeller's toolbox for model analysis. In this review paper, we describe the most frequently used sensitivity techniques, discussing their advantages and limitations, before…

Quantitative Methods · Quantitative Biology 2020-01-14 George Qian , Adam Mahdi

We propose to estimate a metamodel and the sensitivity indices of a complex model m in the Gaussian regression framework. Our approach combines methods for sensitivity analysis of complex models and statistical tools for sparse…

Statistics Theory · Mathematics 2019-11-19 Sylvie Huet , Marie-Luce Taupin

The optimal design of nanoparticle synthesis protocols is often achieved via one-at-a-time experimental designs. Aside from covering a limited space for the possible input conditions, these methods neglect possible interaction between…

Materials Science · Physics 2020-06-23 M. Reza. Andalibi , Paul Bowen , Agnese Carino , Andrea Testino

The Trotter-Suzuki decomposition is one of the main approaches for realization of quantum simulations on digital quantum computers. Variance-based global sensitivity analysis (the Sobol method) is a wide used method which allows to…

Quantum Physics · Physics 2021-01-12 Alexey N. Pyrkov , Yurii Zotov , Jiangyu Cui , Manhong Yung

Development of new multiscale mathematical models often entails considerable complexity and multiple undetermined parameters, typically arising from closure relations. To enable reliable simulations, one must quantify how uncertain physical…

Numerical Analysis · Mathematics 2026-02-26 Linheng Ruan , Ilja Kröker , Sergey Oladyshkin , Iryna Rybak

We present the first application of a variance-based sensitivity analysis (SA) to a model that aims to predict the evolution and properties of the whole galaxy population. SA is a well-established technique in other quantitative sciences,…

Astrophysics of Galaxies · Physics 2020-01-08 Piotr Oleskiewicz , Carlton M. Baugh

This paper addresses sensitivity analysis for dynamic models, linking dependent inputs to observed outputs. The usual method to estimate Sobol indices are based on the independence of input variables. We present a method to overpass this…

Applications · Statistics 2015-09-15 Mathilde Grandjacques , Alexandre Janon , Benoit Delinchant , Olivier Adrot

Variance based global sensitivity analysis measures the relevance of inputs to a single output using Sobol' indices. This paper extends the definition in a natural way to multiple outputs, directly measuring the relevance of inputs to the…

Statistics Theory · Mathematics 2025-03-25 Robert A. Milton , Solomon F. Brown

This study demonstrates the capabilities of several methods for analyzing the sensitivity of neural networks to perturbations of the input data and interpreting their underlying mechanisms. The investigated approaches include the Sobol…

Numerical Analysis · Mathematics 2025-04-22 Jiaxuan Miao , Sergey Matveev

The global sensitivity analysis of a numerical model aims to quantify, by means of sensitivity indices estimate, the contributions of each uncertain input variable to the model output uncertainty. The so-called Sobol' indices, which are…

Statistics Theory · Mathematics 2019-11-26 Bertrand Iooss , Clémentine Prieur

Computational models of the cardiovascular system are increasingly used for the diagnosis, treatment, and prevention of cardiovascular disease. Before being used for translational applications, the predictive abilities of these models need…

Applications · Statistics 2024-01-11 Friederike Schäfer , Daniele E. Schiavazzi , Leif Rune Hellevik , Jacob Sturdy

The estimation of variance-based importance measures (called Sobol' indices) of the input variables of a numerical model can require a large number of model evaluations. It turns to be unacceptable for high-dimensional model involving a…

Statistics Theory · Mathematics 2013-05-28 Matieyendou Lamboni , Bertrand Iooss , Anne-Laure Popelin , Fabrice Gamboa

In the framework of the estimation of safety margins in nuclear accident analysis, a quantitative assessment of the uncertainties tainting the results of computer simulations is essential. Accurate uncertainty propagation (estimation of…

Applications · Statistics 2019-01-01 Bertrand Iooss , Amandine Marrel

Global sensitivity analysis of complex numerical simulators is often limited by the small number of model evaluations that can be afforded. In such settings, surrogate models built from a limited set of simulations can substantially reduce…

Machine Learning · Statistics 2026-01-21 Guerlain Lambert , Céline Helbert , Claire Lauvernet

In the past decade, Sobol's variance decomposition have been used as a tool - among others - in risk management. We show some links between global sensitivity analysis and stochastic ordering theories. This gives an argument in favor of…

Statistics Theory · Mathematics 2014-07-22 Areski Cousin , Alexandre Janon , Véronique Maume-Deschamps , Ibrahima Niang

Uncertainties exist in both physics-based and data-driven models. Variance-based sensitivity analysis characterizes how the variance of a model output is propagated from the model inputs. The Sobol index is one of the most widely used…

Methodology · Statistics 2020-06-09 Zhanlin Liu , Youngjun Choe

In this paper we apply a methodology introduced in Navarro Jimenez et al (2016) in the framework of chemical reaction networks to perform a global sensitivity analysis on simulations of a continuous-time Markov chain model motivated by…

Methodology · Statistics 2024-07-26 Henri Mermoz Kouye , Gildas Mazo , Clémentine Prieur , Elisabeta Vergu

Weighting methods are popular tools for estimating causal effects; assessing their robustness under unobserved confounding is important in practice. In the following paper, we introduce a new set of sensitivity models called "variance-based…

Methodology · Statistics 2023-03-14 Melody Huang , Samuel D. Pimentel

Running a reliability analysis on engineering problems involving complex numerical models can be computationally very expensive, requiring advanced simulation methods to reduce the overall numerical cost. Gaussian process based active…

Machine Learning · Statistics 2020-12-01 Morgane Menz , Sylvain Dubreuil , Jérôme Morio , Christian Gogu , Nathalie Bartoli , Marie Chiron

Sobol indices are a widespread quantitative measure for variance-based global sensitivity analysis, but computing and utilizing them remains challenging for high-dimensional systems. We propose the tensor train decomposition (TT) as a…

Numerical Analysis · Computer Science 2017-12-04 Rafael Ballester-Ripoll , Enrique G. Paredes , Renato Pajarola