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Digital health technologies (DHT), such as wearable devices, provide personalized, continuous, and real-time monitoring of patient. These technologies are contributing to the development of novel therapies and personalized medicine. Gaining…

Quantitative Methods · Quantitative Biology 2024-03-07 Samira Pakravan , Nikolaos Evangelou , Maxime Usdin , Logan Brooks , James Lu

We propose a novel framework for Network Stochastic Differential Equations (N-SDE), where each node in a network is governed by an SDE influenced by interactions with its neighbors. The evolution of each node is driven by the interplay of…

Methodology · Statistics 2025-06-03 Francesco Iafrate , Stefano Iacus

We study the ability of neural networks to calculate feedback control signals that steer trajectories of continuous time non-linear dynamical systems on graphs, which we represent with neural ordinary differential equations (neural ODEs).…

Machine Learning · Computer Science 2022-06-22 Thomas Asikis , Lucas Böttcher , Nino Antulov-Fantulin

Proper regulation of cell signaling and gene expression is crucial for maintaining cellular function, development, and adaptation to environmental changes. Reaction dynamics in cell populations is often noisy because of (i) inherent…

Quantitative Methods · Quantitative Biology 2026-05-12 Jiancheng Zhang , Xiangting Li , Xiaolu Guo , Zhaoyi You , Lucas Böttcher , Alex Mogilner , Alexander Hoffman , Tom Chou , Mingtao Xia

Recent advances in learning dynamical systems from data have shown significant promise. However, many existing methods assume access to the full state of the system -- an assumption that is rarely satisfied in practice, where systems are…

Machine Learning · Computer Science 2026-03-10 Thibault Monsel , Onofrio Semeraro , Lionel Mathelin , Guillaume Charpiat

Stochastic partial differential equations (SPDEs) represent a very active research field with numerous recent developments and breakthrough results. There are several well-established approaches and methods used to construct solutions for…

Probability · Mathematics 2019-08-27 Christian Kuehn , Alexandra Neamtu

We investigate the use of neural networks (NNs) for the estimation of hidden model parameters and uncertainty quantification from noisy observational data for inverse parameter estimation problems. We formulate the parameter estimation as a…

Numerical Analysis · Mathematics 2025-10-17 German Villalobos , Johann Rudi , Andreas Mang

Treatment effect estimation in continuous time is crucial for personalized medicine. However, existing methods for this task are limited to point estimates of the potential outcomes, whereas uncertainty estimates have been ignored. Needless…

Machine Learning · Computer Science 2024-04-04 Konstantin Hess , Valentyn Melnychuk , Dennis Frauen , Stefan Feuerriegel

Neural CDEs provide a natural way to process the temporal evolution of irregular time series. The number of function evaluations (NFE) is these systems' natural analog of depth (the number of layers in traditional neural networks). It is…

Machine Learning · Computer Science 2026-01-27 Ilya Kuleshov , Evgenia Romanenkova , Vladislav Zhuzhel , Galina Boeva , Evgeni Vorsin , Alexey Zaytsev

Clinical time series data from electronic health records and medical registries offer unprecedented opportunities to understand patient trajectories and inform medical decision-making. However, leveraging such data presents significant…

Machine Learning · Computer Science 2025-11-21 Muhammad Aslanimoghanloo , Ahmed ElGazzar , Marcel van Gerven

Predicting outcomes and planning interactions with the physical world are long-standing goals for machine learning. A variety of such tasks involves continuous physical systems, which can be described by partial differential equations…

Machine Learning · Computer Science 2020-01-22 Philipp Holl , Vladlen Koltun , Nils Thuerey

Neural Ordinary Differential Equations (N-ODEs) are a powerful building block for learning systems, which extend residual networks to a continuous-time dynamical system. We propose a Bayesian version of N-ODEs that enables well-calibrated…

Machine Learning · Computer Science 2020-02-19 Andreas Look , Melih Kandemir

Predicting scene dynamics from visual observations is challenging. Existing methods capture dynamics only within observed boundaries failing to extrapolate far beyond the training sequence. Node-RF (Neural ODE-based NeRF) overcomes this…

Computer Vision and Pattern Recognition · Computer Science 2026-03-16 Hiran Sarkar , Liming Kuang , Yordanka Velikova , Benjamin Busam

The reconstruction and inference of stochastic dynamical systems from data is a fundamental task in inverse problems and statistical learning. While surrogate modeling advances computational methods to approximate these dynamics, standard…

Optimization and Control · Mathematics 2026-04-14 Nicole Tianjiao Yang

Effective data-driven PDE forecasting methods often rely on fixed spatial and / or temporal discretizations. This raises limitations in real-world applications like weather prediction where flexible extrapolation at arbitrary spatiotemporal…

Machine Learning · Computer Science 2023-02-16 Yuan Yin , Matthieu Kirchmeyer , Jean-Yves Franceschi , Alain Rakotomamonjy , Patrick Gallinari

Neural ordinary differential equations (NODEs) are an effective approach for data-driven modeling of dynamical systems arising from simulations and experiments. One of the major shortcomings of NODEs, especially when coupled with explicit…

Numerical Analysis · Mathematics 2025-12-30 Allen Alvarez Loya , Daniel A. Serino , J. W. Burby , Qi Tang

Time series modeling and analysis have become critical in various domains. Conventional methods such as RNNs and Transformers, while effective for discrete-time and regularly sampled data, face significant challenges in capturing the…

Machine Learning · Computer Science 2025-09-30 YongKyung Oh , Seungsu Kam , Jonghun Lee , Dong-Young Lim , Sungil Kim , Alex Bui

In this work, we explore modeling change points in time-series data using neural stochastic differential equations (neural SDEs). We propose a novel model formulation and training procedure based on the variational autoencoder (VAE)…

Machine Learning · Computer Science 2025-06-16 Yousef El-Laham , Zhongchang Sun , Haibei Zhu , Tucker Balch , Svitlana Vyetrenko

Modeling continuous dynamical systems from discretely sampled observations is a fundamental problem in data science. Often, such dynamics are the result of non-local processes that present an integral over time. As such, these systems are…

Despite their elegant formulation and lightweight memory cost, neural ordinary differential equations (NODEs) suffer from known representational limitations. In particular, the single flow learned by NODEs cannot express all homeomorphisms…

Machine Learning · Computer Science 2021-04-16 Mathieu Chalvidal , Matthew Ricci , Rufin VanRullen , Thomas Serre