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Motivation: Detailed mechanistic models of biological processes can pose significant challenges for analysis and parameter estimations due to the large number of equations used to track the dynamics of all distinct configurations in which…

Molecular Networks · Quantitative Biology 2020-12-16 Alexey Ovchinnikov , Isabel Cristina Pérez Verona , Gleb Pogudin , Mirco Tribastone

Kinetic models of biochemical systems used in the modern literature often contain hundreds or even thousands of variables. While these models are convenient for detailed simulations, their size is often an obstacle to deriving mechanistic…

Molecular Networks · Quantitative Biology 2021-06-29 Gleb Pogudin , Xingjian Zhang

Dynamical models described by ordinary differential equations (ODEs) are a fundamental tool in the sciences and engineering. Exact reduction aims at producing a lower-dimensional model in which each macro-variable can be directly related to…

Systems and Control · Electrical Eng. & Systems 2024-01-05 Alexander Demin , Elizaveta Demitraki , Gleb Pogudin

Gaining insights from realistic dynamical models of biochemical systems can be challenging given their large number of state variables. Model reduction techniques can mitigate this by decreasing complexity by mapping the model onto a…

Computational Engineering, Finance, and Science · Computer Science 2024-11-22 Alexander Leguizamon-Robayo , Antonio Jiménez-Pastor , Micro Tribastone , Max Tschaikowski , Andrea Vandin

We present an exact dimensional reduction for high-dimensional dynamical systems composed of $N$ identical dynamical units governed by quasi-linear ordinary differential equations (ODEs) of order $M$. In these systems, each unit follows a…

Adaptation and Self-Organizing Systems · Physics 2026-05-15 Felix Augustsson , Erik Andreas Martens , Rok Cestnik

The reduction of dynamical systems has a rich history, with many important applications related to stability, control and verification. Reduction of nonlinear systems is typically performed in an exact manner - as is the case with…

Optimization and Control · Mathematics 2007-07-26 Paulo Tabuada , Aaron D. Ames , Agung Julius , George J. Pappas

Modeling complex physical dynamics is a fundamental task in science and engineering. Traditional physics-based models are sample efficient, and interpretable but often rely on rigid assumptions. Furthermore, direct numerical approximation…

Machine Learning · Computer Science 2023-03-02 Rui Wang , Rose Yu

Predictive simulations of complex systems are essential for applications ranging from weather forecasting to drug design. The veracity of these predictions hinges on their capacity to capture the effective system dynamics. Massively…

Computational Physics · Physics 2021-10-20 Pantelis R. Vlachas , Georgios Arampatzis , Caroline Uhler , Petros Koumoutsakos

Direct numerical simulation of dynamical systems is of fundamental importance in studying a wide range of complex physical phenomena. However, the ever-increasing need for accuracy leads to extremely large-scale dynamical systems whose…

Dynamical Systems · Mathematics 2015-03-04 Jeff T. Borggaard , Serkan Gugercin

Many robotics applications require alignment and fusion of observations obtained at multiple views to form a global model of the environment. Multi-way data association methods provide a mechanism to improve alignment accuracy of pairwise…

Robotics · Computer Science 2020-03-06 Kaveh Fathian , Kasra Khosoussi , Yulun Tian , Parker Lusk , Jonathan P. How

Artificial intelligence systems predominantly rely on static data distributions, making them ineffective in dynamic real-world environments, such as cybersecurity, autonomous transportation, or finance, where data shifts frequently.…

Machine Learning · Computer Science 2026-03-19 Isabella Marasco , Davide Evangelista , Elena Loli Piccolomini , Michele Colajanni

Many complex engineering systems consist of multiple subsystems that are developed by different teams of engineers. To analyse, simulate and control such complex systems, accurate yet computationally efficient models are required. Modular…

Systems and Control · Electrical Eng. & Systems 2023-01-02 Lars A. L. Janssen , Bart Besselink , Rob H. B. Fey , Nathan van de Wouw

We consider reduction of dimension for nonlinear dynamical systems. We demonstrate that in some cases, one can reduce a nonlinear system of equations into a single equation for one of the state variables, and this can be useful for…

Chaotic Dynamics · Physics 2015-08-25 Heather A. Harrington , Robert A. Van Gorder

In this paper, practically computable low-order approximations of potentially high-dimensional differential equations driven by geometric rough paths are proposed and investigated. In particular, equations are studied that cover the linear…

Numerical Analysis · Mathematics 2023-07-03 Martin Redmann , Sebastian Riedel

Data driven models of dynamical systems help planners and controllers to provide more precise and accurate motions. Most model learning algorithms will try to minimize a loss function between the observed data and the model's predictions.…

Artificial Intelligence · Computer Science 2021-02-12 Clark Zhang , Santiago Paternain , Alejandro Ribeiro

Research on control using models based on machine-learning methods has now shifted to the practical engineering stage. Achieving high performance and theoretically guaranteeing the safety of the system is critical for such applications. In…

Systems and Control · Electrical Eng. & Systems 2025-01-28 Ryuta Moriyasu , Masayuki Kusunoki , Kenji Kashima

Why does a phenomenon occur? Addressing this question is central to most scientific inquiries and often relies on simulations of scientific models. As models become more intricate, deciphering the causes behind phenomena in high-dimensional…

Machine Learning · Statistics 2024-06-04 Armin Kekić , Bernhard Schölkopf , Michel Besserve

Clustering algorithms are at the basis of several technological applications, and are fueling the development of rapidly evolving fields such as machine learning. In the recent past, however, it has become apparent that they face challenges…

Reliable uncertainty estimation is critical for deploying neural networks (NNs) in real-world applications. While existing calibration techniques often rely on post-hoc adjustments or coarse-grained binning methods, they remain limited in…

Machine Learning · Computer Science 2025-05-30 Pedro Mendes , Paolo Romano , David Garlan

Multiscale dynamics are ubiquitous in applications of modern science. Because of time scale separation between relatively small set of slowly evolving variables and (typically) much larger set of rapidly changing variables, direct numerical…

Dynamical Systems · Mathematics 2016-04-08 Rafail V. Abramov
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