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Proton therapy is a modality in fast development. Characterized by a maximum dose deposition at the end of the proton trajectory followed by a sharp fall-off, proton beams can deliver a highly conformal dose to the tumor while sparing…

Medical Physics · Physics 2022-05-18 François Smekens , Nicolas Freud , Bruno Sixou , Guillaume Beslon , Jean M Létang

This paper introduces a procedure based on genetic programming to evolve XSLT programs (usually called stylesheets or logicsheets). XSLT is a general purpose, document-oriented functional language, generally used to transform XML documents…

Neural and Evolutionary Computing · Computer Science 2007-12-18 Nestor Zorzano , Daniel Merino , J. L. J. Laredo , J. P. Sevilla , Pablo Garcia , J. J. Merelo

The $(1+(\lambda,\lambda))$ genetic algorithm is a bright example of an evolutionary algorithm which was developed based on the insights from theoretical findings. This algorithm uses crossover, and it was shown to asymptotically outperform…

Neural and Evolutionary Computing · Computer Science 2020-05-12 Anton Bassin , Maxim Buzdalov

Generative optimization uses large language models (LLMs) to iteratively improve artifacts (such as code, workflows or prompts) using execution feedback. It is a promising approach to building self-improving agents, yet in practice remains…

Large Language Models (LLMs) typically generate outputs token by token using a fixed compute budget, leading to inefficient resource utilization. To address this shortcoming, recent advancements in mixture of expert (MoE) models,…

Auto-vectorization is a fundamental optimization for modern compilers to exploit SIMD parallelism. However, state-of-the-art approaches still struggle to handle intricate code patterns, often requiring manual hints or domain-specific…

Software Engineering · Computer Science 2025-06-05 Zhongchun Zheng , Kan Wu , Long Cheng , Lu Li , Rodrigo C. O. Rocha , Tianyi Liu , Wei Wei , Jianjiang Zeng , Xianwei Zhang , Yaoqing Gao

Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the…

Biomolecules · Quantitative Biology 2019-04-23 Kevin K. Yang , Zachary Wu , Frances H. Arnold

With the decline of Moore's law, optimizing program performance has become a major focus of software research. However, high-level optimizations such as API and algorithm changes remain elusive due to the difficulty of understanding the…

Evolutionary computation (EC), as a powerful optimization algorithm, has been applied across various domains. However, as the complexity of problems increases, the limitations of EC have become more apparent. The advent of large language…

Neural and Evolutionary Computing · Computer Science 2024-05-24 Jinyu Cai , Jinglue Xu , Jialong Li , Takuto Ymauchi , Hitoshi Iba , Kenji Tei

A common claim of evolutionary computation methods is that they can achieve good results without the need for human intervention. However, one criticism of this is that there are still hyperparameters which must be tuned in order to achieve…

Neural and Evolutionary Computing · Computer Science 2021-02-11 Benjamin Patrick Evans , Bing Xue , Mengjie Zhang

Large Language Models (LLMs) employ three popular training approaches: Masked Language Models (MLM), Causal Language Models (CLM), and Sequence-to-Sequence Models (seq2seq). However, each approach has its strengths and limitations, and…

Machine Learning · Computer Science 2025-02-18 Xuefeng Liu , Songhao Jiang , Bo Li , Rick Stevens

In Computer Vision, problem of identifying or classifying the objects present in an image is called Object Categorization. It is a challenging problem, especially when the images have clutter background, occlusions or different lighting…

Computer Vision and Pattern Recognition · Computer Science 2016-04-26 Jyothi Korra

While Large Language Models (LLMs) have significantly advanced code generation efficiency, they face inherent challenges in balancing performance and inference costs across diverse programming tasks. Dynamically selecting the optimal LLM…

Software Engineering · Computer Science 2025-06-13 Junhang Cheng , Fang Liu , Chengru Wu , Li Zhang

Feature transformation aims to reconstruct the feature space of raw features to enhance the performance of downstream models. However, the exponential growth in the combinations of features and operations poses a challenge, making it…

Machine Learning · Computer Science 2024-12-19 Nanxu Gong , Chandan K. Reddy , Wangyang Ying , Haifeng Chen , Yanjie Fu

We employ an evolutionary algorithm to automatically optimize different stages of a cold atom experiment without human intervention. This approach closes the loop between computer based experimental control systems and automatic real time…

Vectorial Genetic Programming (Vec-GP) extends GP by allowing vectors as input features along regular, scalar features, using them by applying arithmetic operations component-wise or aggregating vectors into scalars by some aggregation…

Neural and Evolutionary Computing · Computer Science 2023-03-07 Philipp Fleck , Stephan Winkler , Michael Kommenda , Michael Affenzeller

Optimization for deep networks is currently a very active area of research. As neural networks become deeper, the ability in manually optimizing the network becomes harder. Mini-batch normalization, identification of effective respective…

Neural and Evolutionary Computing · Computer Science 2018-08-07 M. U. B. Dias , D. D. N. De Silva , S. Fernando

The phase ordering problem has been a long-standing challenge since the late 1970s, yet it remains an open problem due to having a vast optimization space and an unbounded nature, making it an open-ended problem without a finite solution,…

Sequence Alignment is the process of aligning biological sequences in order to identify similarities between multiple sequences. In this paper, a Quantum Algorithm for finding the optimal alignment between DNA sequences has been…

Data Structures and Algorithms · Computer Science 2025-09-05 Md. Rabiul Islam Khan , Shadman Shahriar , Shaikh Farhan Rafid

Large language models (LLMs) are increasingly used for complex tasks that require multiple generation calls, advanced prompting techniques, control flow, and structured inputs/outputs. However, efficient systems are lacking for programming…