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The fast-growing field of soft matter research requires increasingly sophisticated tools for experimental studies. One of the oldest and most widely used tools to study soft matter systems is optical microscopy. Recent advances in optical…

Soft Condensed Matter · Physics 2011-08-17 Taewoo Lee , Bohdan Senyuk , Rahul P. Trivedi , Ivan I. Smalyukh

We are developing multi-chroic antenna-coupled TES detectors for CMB polarimetry. Multi-chroic detectors increase the mapping speed per focal plane area and provide greater discrimination of polarized galactic foregrounds with no increase…

Wide-field fluorescence microscopy, while much faster than confocal microscopy, suffers from a lack of optical sectioning and poor axial resolution. 3D structured illumination microscopy (SIM) has been demonstrated to provide optical…

Chlorophyll fluorescence (CF) is a key indicator to study plant physiology or photosynthesis efficiency. Conventionally, CF is characterized by fluorometers, which only allows ensemble measurement through wide-field detection. For imaging…

Biological Physics · Physics 2016-11-10 Yi-Chin Tseng , Shi-Wei Chu

Intracellular structural alterations are hallmark of several disease conditions and treatment modalities. However, robust methods to quantify these changes are scarce. In view of this, we introduce a new method to quantify structural…

A lateral shear interferometer based digital holographic microscopy has been realized to study the morphology dynamics of Human red blood cells quantitatively. Here, a lateral shear interferometer is embedded with a conventional microscope…

Image and Video Processing · Electrical Eng. & Systems 2019-09-10 Shital Devinder , Ashish Lal , Tathagato Rai Dastidar , Satish Kumar Dubey

Temporal focusing two-photon microscopy enables high resolution imaging of fine structures in vivo over a large volume. A limitation of temporal focusing is that signal-to-background ratio and resolution degrade rapidly with increasing…

Mid-infrared spectroscopy probes molecular vibrations to identify chemical species and functional groups. Therefore, mid-infrared hyperspectral imaging is one of the most powerful and promising candidates for chemical imaging using optical…

Optics · Physics 2023-07-06 Yue Zhao , Shota Kusama , Yuji Furutani , Wei-Hong Huang , Chih-Wei Luo , Takao Fuji

Imaging is of great importance in everyday life and various fields of science and technology. Conventional imaging is achieved by bending light rays originating from an object with a lens. Such ray bending requires space-variant structures,…

Optics · Physics 2023-10-02 Wenzhe Liu , Jingguang Chen , Tongyu Li , Zhe Zhang , Fang Guan , Lei Shi , Jian Zi , C. T. Chan

The transmission electron microscope facilitates the highest-resolution imaging of any instrument ever created, and its limiting factor is no longer spatial resolution but dose efficiency. Low electron doses avoid sample damage but produce…

Machine Learning · Computer Science 2026-05-08 Georgia Channing , Debora Keller , Marta D. Rossell , Philip Torr , Stig Helveg , Henrik Eliasson

Optical imaging plays a critical role in advancing our understanding of three dimensional dynamics of biological systems. Coherent imaging (CI) methods exploit spatial phase information, encoded through propagation of coherent signal light…

Optics · Physics 2015-07-24 Jeffrey J. Field , David G. Winters , Randy A. Bartels

This paper presents the mechanical design of a distal scanner to perform a spiral scan for mosaic-imaging with a confocal microlaparoscope. First, it is demonstrated with ex vivo experiments that a spiral scan performs better than a raster…

Robotics · Computer Science 2018-04-16 Mustafa Suphi Erden , Benoît Rosa , Jérome Szewczyk , Guillaume Morel

In this work, image analysis techniques used in astrophysics to detect low-contrast signals have been adapted in the processing of Computed Tomography (CT) images, combining Centroidal Voronoi Tessellation (CVT) and machine learning…

Medical Physics · Physics 2025-03-11 Lorenzo Lasagni

Here we report nonlinear focal modulation microscopy (NFOMM) to achieve super-resolution imaging. Abandoning the previous persistence on minimizing the size of Gaussian emission pattern by directly narrowing (e.g. Minimizing the detection…

Phase imaging is gaining importance due to its applications in fields like biomedical imaging and material characterization. In biomedical applications, it can provide quantitative information missing in label-free microscopy modalities.…

Image and Video Processing · Electrical Eng. & Systems 2026-02-20 Gabriel della Maggiora , Luis Alberto Croquevielle , Harry Horsley , Thomas Heinis , Artur Yakimovich

We report a development of a multi-color simultaneous camera for the 188cm telescope at Okayama Astrophysical Observatory in Japan. The instrument, named MuSCAT, has a capability of 3-color simultaneous imaging in optical wavelength where…

Instrumentation and Methods for Astrophysics · Physics 2015-09-11 Norio Narita , Akihiko Fukui , Nobuhiko Kusakabe , Masahiro Onitsuka , Tsuguru Ryu , Kenshi Yanagisawa , Hideyuki Izumiura , Motohide Tamura , Tomoyasu Yamamuro

An innovative X-ray imaging sensor with intrinsic digital characteristics is presented. It is based on Chromatic Photon Counting technology. The detector is able to count individually the incident X-ray photons and to separate them…

Instrumentation and Detectors · Physics 2015-06-11 R. Bellazzini , G. Spandre , A. Brez , M. Minuti , M. Pinchera , P. Mozzo

CT scanners that are commonly-used in hospitals nowadays produce low-resolution images, up to 512 pixels in size. One pixel in the image corresponds to a one millimeter piece of tissue. In order to accurately segment tumors and make…

Computer Vision and Pattern Recognition · Computer Science 2023-04-07 Mariana-Iuliana Georgescu , Radu Tudor Ionescu , Nicolae Verga

We propose a novel method to perform plenoptic imaging at the diffraction limit by measuring second-order correlations of light between two reference planes, arbitrarily chosen, within the tridimensional scene of interest. We show that for…

Magnetic resonance imaging is capable of producing volumetric images without ionizing radiation. Nonetheless, long acquisitions lead to prohibitively long exams. Compressed sensing (CS) can enable faster scanning via sub-sampling with…

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