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Hybrid quantum mechanical-molecular mechanical (QM/MM) simulations are widely used in enzyme simulation. Over ten convergence studies of QM/MM methods have revealed over the past several years that key energetic and structural properties…

Chemical Physics · Physics 2017-01-11 Maria Karelina , Heather J. Kulik

The connect-fill-run workflow paradigm, widely adopted in mature software engineering, accelerates collaborative development. However, computational chemistry, computational materials science, and computational biology face persistent…

Chemical Physics · Physics 2025-08-12 Jianan Wang , Wenbo Guo , Xin Yue , Minjie Xu , Yueqiang Zheng , Jingxiang Dong , Jiarui Hu , Jian Xia , Chuixiong Wu

Background: Understanding electronic interactions in protein active sites is fundamental to drug discovery and enzyme engineering, but remains computationally challenging due to exponential scaling of quantum mechanical calculations.…

Quantitative Methods · Quantitative Biology 2026-01-05 Biraja Ghoshal

Multiobjective simulation optimization (MOSO) problems are optimization problems with multiple conflicting objectives, where evaluation of at least one of the objectives depends on a black-box numerical code or real-world experiment, which…

Optimization and Control · Mathematics 2025-01-13 Tyler H. Chang , Stefan M. Wild

For a specific quantum chip, multi-programming helps to improve overall throughput and resource utilization. However, the previous solutions for mapping multiple programs onto a quantum chip often lead to resource under-utilization, high…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-04-28 Lei Liu , Xinglei Dou

Quantitative Structure-Activity Relationship (QSAR) modeling is key in drug discovery, but classical methods face limitations when handling high-dimensional data and capturing complex molecular interactions. This research proposes enhancing…

Quantum Physics · Physics 2025-07-09 Alejandro Giraldo , Daniel Ruiz , Mariano Caruso , Guido Bellomo

When a pulsed, few-cycle electromagnetic wave is focused by optics with f-number smaller than two, the frequency components it contains are focused to different regions of space, building up a complex electromagnetic field structure.…

Next-generation multiple-input multiple-output (MIMO) systems, characterized by extremely large-scale arrays, holographic surfaces, three-dimensional architectures, and flexible antennas, are poised to deliver unprecedented data rates,…

Information Theory · Computer Science 2025-10-07 Jian Xiao , Ji Wang , Qi Sun , Qimei Cui , Xingwang Li , Dusit Niyato , Chih-Lin I

Purpose: Real-time monitoring of cardiac output (CO) requires low latency reconstruction and segmentation of real-time phase contrast MR (PCMR), which has previously been difficult to perform. Here we propose a deep learning framework for…

Computer Vision and Pattern Recognition · Computer Science 2023-02-07 Olivier Jaubert , Javier Montalt-Tordera , James Brown , Daniel Knight , Simon Arridge , Jennifer Steeden , Vivek Muthurangu

The unique capability of quantum mechanics to evolve alternative possibilities in parallel is appealing and over the years a number of quantum algorithms have been developed offering great computational benefits. Systems coupled to the…

Disordered Systems and Neural Networks · Physics 2013-11-20 Gabor Vattay , Stuart A. Kauffman

Identifying a small molecule from its mass spectrum is the primary open problem in computational metabolomics. This is typically cast as information retrieval: an unknown spectrum is matched against spectra predicted computationally from a…

Machine Learning · Computer Science 2023-01-30 Michael Murphy , Stefanie Jegelka , Ernest Fraenkel , Tobias Kind , David Healey , Thomas Butler

We describe the use of Multi Order Coverage (MOC) maps as a practical way to manage complex regions of the sky for the planning of multi-messenger observations. MOC maps are a data structure that provides a multi-resolution representation…

A virtual multiple-input multiple-output (MIMO) wireless system using the receiver-side cooperation with the compress-and-forward (CF) protocol, is an alternative to a point-to-point MIMO system, when a single receiver is not equipped with…

Information Theory · Computer Science 2013-02-11 Jing Jiang , John S. Thompson , Hongjian Sun , Peter M. Grant

Among the objectives toward large-scale quantum computation is the quantum interconnect: a device which uses photons to interface qubits that otherwise could not interact. However, current approaches require photons indistinguishable in…

Quantum Physics · Physics 2016-12-23 Joseph M. Lukens , Pavel Lougovski

In this work, we propose a new flow-matching Markov chain Monte Carlo (FM-MCMC) algorithm for estimating the orbital parameters of exoplanetary systems, especially for those only one exoplanet is involved. Compared to traditional methods…

Earth and Planetary Astrophysics · Physics 2025-11-10 Bo Liang , Hanlin Song , Chang Liu , Tianyu Zhao , Yuxiang Xu , Zihao Xiao , Manjia Liang , Minghui Du , Wei-Liang Qian , Li-e Qiang , Peng Xu , Ziren Luo

Quantum cloud computing enables remote access to quantum processors, yet the heterogeneity and noise of available quantum hardware create significant challenges for efficient resource orchestration. These issues complicate the optimization…

Quantum Physics · Physics 2025-08-08 Hoa T. Nguyen , Muhammad Usman , Rajkumar Buyya

The analysis of spatial observations on a sphere is important in areas such as geosciences, physics and embryo research, just to name a few. The purpose of the package rcosmo is to conduct efficient information processing, visualisation,…

Computation · Statistics 2019-07-15 Daniel Fryer , Ming Li , Andriy Olenko

Model-Based Iterative Reconstruction (MBIR) is important because direct methods, such as Filtered Back-Projection (FBP) can introduce significant noise and artifacts in sparse-angle tomography, especially for time-evolving samples. Although…

Mathematical Software · Computer Science 2026-03-31 Dinesh Kumar , Jeffrey Donatelli

In advancing discrete-based computational cancer models towards clinical applications, one faces the dilemma of how to deal with an ever growing amount of biomedical data that ought to be incorporated eventually in one form or another.…

Cell Behavior · Quantitative Biology 2008-06-26 Le Zhang , L. Leon Chen , Thomas S. Deisboeck

A closed-form algorithm, named "concerto", is proposed for phase-based distance estimation in multi-frequency phase unwrapping (MFPU) system. The concerto method consists of three coherent estimation stages,i.e., initial modified BW…

Information Theory · Computer Science 2017-02-21 Li Wei , Wangdong Qi