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Whole Slide Image (WSI) classification remains a challenge due to their extremely high resolution and the absence of fine-grained labels. Presently, WSI classification is usually regarded as a Multiple Instance Learning (MIL) problem when…

Computer Vision and Pattern Recognition · Computer Science 2023-08-24 Hongyi Wang , Luyang Luo , Fang Wang , Ruofeng Tong , Yen-Wei Chen , Hongjie Hu , Lanfen Lin , Hao Chen

Machine learning models have had discernible achievements in a myriad of applications. However, most of these models are black-boxes, and it is obscure how the decisions are made by them. This makes the models unreliable and untrustworthy.…

Machine Learning · Computer Science 2020-03-23 Raha Moraffah , Mansooreh Karami , Ruocheng Guo , Adrienne Raglin , Huan Liu

Multiple instance learning (MIL) is a powerful approach to classify whole slide images (WSIs) for diagnostic pathology. A fundamental challenge of MIL on WSI classification is to discover the \textit{critical instances} that trigger the bag…

Computer Vision and Pattern Recognition · Computer Science 2022-09-02 Zhikang Wang , Yue Bi , Tong Pan , Xiaoyu Wang , Chris Bain , Richard Bassed , Seiya Imoto , Jianhua Yao , Jiangning Song

In multi-task learning, a learner is given a collection of prediction tasks and needs to solve all of them. In contrast to previous work, which required that annotated training data is available for all tasks, we consider a new setting, in…

Machine Learning · Statistics 2017-06-09 Anastasia Pentina , Christoph H. Lampert

Multiple Instance Learning (MIL) has been widely applied to medical imaging diagnosis, where bag labels are known and instance labels inside bags are unknown. Traditional MIL assumes that instances in each bag are independent samples from a…

Image and Video Processing · Electrical Eng. & Systems 2023-07-19 Yunan Wu , Francisco M. Castro-Macías , Pablo Morales-Álvarez , Rafael Molina , Aggelos K. Katsaggelos

Automated machine learning (AutoML) systems aim to enable training machine learning (ML) models for non-ML experts. A shortcoming of these systems is that when they fail to produce a model with high accuracy, the user has no path to improve…

Machine Learning · Computer Science 2021-02-23 Behnaz Arzani , Kevin Hsieh , Haoxian Chen

Being able to interpret, or explain, the predictions made by a machine learning model is of fundamental importance. This is especially true when there is interest in deploying data-driven models to make high-stakes decisions, e.g. in…

Machine Learning · Computer Science 2019-10-01 An-phi Nguyen , María Rodríguez Martínez

A salient approach to interpretable machine learning is to restrict modeling to simple models. In the Bayesian framework, this can be pursued by restricting the model structure and prior to favor interpretable models. Fundamentally,…

Machine Learning · Computer Science 2020-09-08 Homayun Afrabandpey , Tomi Peltola , Juho Piironen , Aki Vehtari , Samuel Kaski

In Multiple Instance learning (MIL), weak labels are provided at the bag level with only presence/absence information known. However, there is a considerable gap in performance in comparison to a fully supervised model, limiting the…

Machine Learning · Computer Science 2021-03-22 Anxiang Zhang , Ankit Shah , Bhiksha Raj

In-context learning (ICL) enables multimodal large language models (MLLMs) to classify images from a few labelled examples. Yet, how these models use the provided context remains opaque. While Chain-of-Thought prompting is widely used,…

Artificial Intelligence · Computer Science 2026-05-28 Carmen Quiles-Ramírez , Leticia L. Rodríguez , Nicolás Martorell , Natalia Díaz-Rodríguez

Annotating multi-class instances is a crucial task in the field of machine learning. Unfortunately, identifying the correct class label from a long sequence of candidate labels is time-consuming and laborious. To alleviate this problem, we…

Machine Learning · Computer Science 2025-12-05 Meng Wei , Zhongnian Li , Yong Zhou , Qiaoyu Guo , Xinzheng Xu

Models often need to be constrained to a certain size for them to be considered interpretable. For example, a decision tree of depth 5 is much easier to understand than one of depth 50. Limiting model size, however, often reduces accuracy.…

Machine Learning · Computer Science 2020-07-02 Abhishek Ghose , Balaraman Ravindran

Predictive models deployed in the real world may assign incorrect labels to instances with high confidence. Such errors or unknown unknowns are rooted in model incompleteness, and typically arise because of the mismatch between training…

Artificial Intelligence · Computer Science 2016-12-13 Himabindu Lakkaraju , Ece Kamar , Rich Caruana , Eric Horvitz

Machine learning has shown much promise in helping improve the quality of medical, legal, and financial decision-making. In these applications, machine learning models must satisfy two important criteria: (i) they must be causal, since the…

Machine Learning · Computer Science 2021-10-12 Carolyn Kim , Osbert Bastani

The ability to interpret machine learning models has become increasingly important now that machine learning is used to inform consequential decisions. We propose an approach called model extraction for interpreting complex, blackbox…

Machine Learning · Computer Science 2018-03-14 Osbert Bastani , Carolyn Kim , Hamsa Bastani

Weakly supervised machine learning algorithms are able to learn from ambiguous samples or labels, e.g., multi-instance learning or partial-label learning. However, in some real-world tasks, each training sample is associated with not only…

Machine Learning · Computer Science 2022-12-20 Wei Tang , Weijia Zhang , Min-Ling Zhang

Identification of input data points relevant for the classifier (i.e. serve as the support vector) has recently spurred the interest of researchers for both interpretability as well as dataset debugging. This paper presents an in-depth…

Machine Learning · Computer Science 2020-09-30 Dominique Mercier , Shoaib Ahmed Siddiqui , Andreas Dengel , Sheraz Ahmed

In this paper, we address the Multi-Instance-Learning (MIL) problem when bag labels are naturally represented as ordinal variables (Multi--Instance--Ordinal Regression). Moreover, we consider the case where bags are temporal sequences of…

Computer Vision and Pattern Recognition · Computer Science 2016-09-07 Adria Ruiz , Ognjen Rudovic , Xavier Binefa , Maja Pantic

Through extensive experience developing and explaining machine learning (ML) applications for real-world domains, we have learned that ML models are only as interpretable as their features. Even simple, highly interpretable model types such…

Machine Learning · Computer Science 2022-02-25 Alexandra Zytek , Ignacio Arnaldo , Dongyu Liu , Laure Berti-Equille , Kalyan Veeramachaneni

Multiple Instance Learning (MIL) for whole slide image (WSI) analysis in computational pathology often neglects instance-level learning as supervision is typically provided only at the bag level, hindering the integrated consideration of…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Shuyang Wu , Yifu Qiu , Ines P. Nearchou , Sandrine Prost , Jonathan A. Fallowfield , Hideki Ueno , Hitoshi Tsuda , David J. Harrison , Hakan Bilen , Timothy J. Kendall
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