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Recent advances in experimental neuroscience allow, for the first time, non-invasive studies of the white matter tracts in the human central nervous system, thus making available cutting-edge brain anatomical data describing these global…

Quantitative Methods · Quantitative Biology 2008-11-06 Jonathan J. Crofts , Desmond J. Higham

To understand the biological characteristics of neurological disorders with functional connectivity (FC), recent studies have widely utilized deep learning-based models to identify the disease and conducted post-hoc analyses via explainable…

Machine Learning · Computer Science 2023-10-09 Eunsong Kang , Da-woon Heo , Jiwon Lee , Heung-Il Suk

Predicting cognition from neuroimaging data in healthy individuals offers insights into the neural mechanisms underlying cognitive abilities, with potential applications in precision medicine and early detection of neurological and…

Machine Learning · Computer Science 2025-07-29 Jagruti Patel , Mikkel Schöttner , Thomas A. W. Bolton , Patric Hagmann

Understanding how neural dynamics shape cognitive experiences remains a central challenge in neuroscience and psychiatry. Here, we present a novel framework leveraging state-to-output controllability from dynamical systems theory to model…

Effective connectivity analysis in functional magnetic resonance imaging (fMRI) studies directional interactions among brain regions and experimental stimuli. Dynamic causal modeling (DCM) is a widely used method to estimate effective…

Methodology · Statistics 2026-05-15 Kaitlyn R. Fales , Hyebin Song , Nicole A. Lazar

This paper studies the link between resting-state functional connectivity (FC), measured by the correlations of the fMRI BOLD time courses, and structural connectivity (SC), estimated through fiber tractography. Instead of a static analysis…

Studies in recent years have demonstrated that neural organization and structure impact an individual's ability to perform a given task. Specifically, individuals with greater neural efficiency have been shown to outperform those with less…

Neuroimaging-driven prediction of brain age, defined as the predicted biological age of a subject using only brain imaging data, is an exciting avenue of research. In this work we seek to build models of brain age based on functional…

Learning requires the traversal of inherently distinct cognitive states to produce behavioral adaptation. Yet, tools to explicitly measure these states with non-invasive imaging -- and to assess their dynamics during learning -- remain…

Machine learning provides a valuable tool for analyzing high-dimensional functional neuroimaging data, and is proving effective in predicting various neurological conditions, psychiatric disorders, and cognitive patterns. In functional…

Machine Learning · Computer Science 2024-11-25 Anwar Said , Roza G. Bayrak , Tyler Derr , Mudassir Shabbir , Daniel Moyer , Catie Chang , Xenofon Koutsoukos

Recent research has established both a theoretical basis and strong empirical evidence that effective social behavior plays a beneficial role in the maintenance of physical and psychological well-being of people. To test whether social…

Social and Information Networks · Computer Science 2017-05-29 Xinpei Ma , Hiroki Sayama

While different neuroimaging modalities have been proposed to detect mental stress, each modality experiences certain limitations. This study proposed novel approaches to detect stress based on fusion of EEG and fNIRS signals in the…

Neurons and Cognition · Quantitative Biology 2019-03-21 Fares Al-Shargie

Increased variability in performance has been associated with the emergence of several neurological and psychiatric pathologies. However, whether and how consistency of neuronal activity may also be indicative of an underlying pathology is…

Neurons and Cognition · Quantitative Biology 2014-10-31 J. H. Martínez , J. M. Pastor , P. Ariza , M. Zanin , D. Papo , F. Maestú , R. Bajo , S. Boccaletti , J. M. Buldú

Functional connectivity (FC) analysis of resting-state fMRI data provides a framework for characterizing brain networks and their association with participant-level covariates. Due to the high dimensionality of neuroimaging data, standard…

Methodology · Statistics 2025-08-18 Wei Zhao , Brian J. Reich , Emily C. Hector

Action, cognition, emotion and perception can be mapped in the brain by using set of techniques. Translating unimodal concepts from one modality to another is an important step towards understanding the neural mechanisms. This paper…

Other Computer Science · Computer Science 2012-12-18 Revati Shriram , Dr. M. Sundhararajan , Nivedita Daimiwal

Since the beginning of the 21st century, the size, breadth, and granularity of data in biology and medicine has grown rapidly. In the example of neuroscience, studies with thousands of subjects are becoming more common, which provide…

Knowing brain connectivity is of great importance both in basic research and for clinical applications. We are proposing a method to infer directed connectivity from zero-lag covariances of neuronal activity recorded at multiple sites. This…

Neurons and Cognition · Quantitative Biology 2018-04-10 Jonathan Schiefer , Alexander Niederbühl , Volker Pernice , Carolin Lennartz , Pierre LeVan , Jürgen Henning , Stefan Rotter

We present a data-driven framework to characterize large-scale brain dynamical states directly from correlation matrices at the single-subject level. By treating correlation thresholding as a percolation-like probe of connectivity, the…

To understand neural network behavior, recent works quantitatively compare different networks' learned representations using canonical correlation analysis (CCA), centered kernel alignment (CKA), and other dissimilarity measures.…

Machine Learning · Computer Science 2021-11-04 Frances Ding , Jean-Stanislas Denain , Jacob Steinhardt

We consider exploratory methods for the discovery of cortical functional connectivity. Typically, data for the i-th subject (i=1...NS) is represented as an NVxNT matrix Xi, corresponding to brain activity sampled at NT moments in time from…

Methodology · Statistics 2011-03-17 Roberto D. Pascual-Marqui , Rolando J. Biscay-Lirio