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Molecularly targeted contrast enhanced ultrasound (mCEUS) is a clinically promising approach for early cancer detection through targeted imaging of VEGFR2 (KDR) receptors. We have developed computational enhancement techniques for mCEUS…

Image and Video Processing · Electrical Eng. & Systems 2020-06-23 Andrew A. Berlin , Mon Young , Ahmed El Kaffas , Sam Gambhir , Amelie Lutz , Maria Luigia Storto , Juergen Willmann

Three-dimensional ultrasound enables real-time volumetric visualization of anatomical structures. Unlike traditional 2D ultrasound, 3D imaging reduces reliance on precise probe orientation, potentially making ultrasound more accessible to…

Image and Video Processing · Electrical Eng. & Systems 2026-05-05 Tristan S. W. Stevens , Oisín Nolan , Oudom Somphone , Jean-Luc Robert , Ruud J. G. van Sloun

Purpose: Spinal instability is a widespread condition that causes pain, fatigue, and restricted mobility, profoundly affecting patients' quality of life. In clinical practice, the gold standard for diagnosis is dynamic X-ray imaging.…

Medical Physics · Physics 2026-02-16 Feng Li , Yuan Bi , Tianyu Song , Zhongliang Jiang , Nassir Navab

Ultrasound (US) imaging is a vital adjunct to mammography in breast cancer screening and diagnosis, but its reliance on hand-held transducers often lacks repeatability and heavily depends on sonographers' skills. Integrating US systems from…

Robotics · Computer Science 2023-12-19 Yuxin Chen , Yifan Yin , Julian Brown , Kevin Wang , Yi Wang , Ziyi Wang , Russell H. Taylor , Yixuan Wu , Emad M. Boctor

4D Computed Tomography (4DCT) is widely used for many clinical applications such as radiotherapy treatment planning, PET and ventilation imaging. However, common 4DCT methods reconstruct multiple breath cycles into a single, arbitrary…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Yuliang Huang , Bjoern Eiben , Kris Thielemans , Jamie R. McClelland

A crucial limitation of current high-resolution 3D photoacoustic tomography (PAT) devices that employ sequential scanning is their long acquisition time. In previous work, we demonstrated how to use compressed sensing techniques to improve…

Numerical Analysis · Mathematics 2020-09-07 Felix Lucka , Nam Huynh , Marta Betcke , Edward Zhang , Paul Beard , Ben Cox , Simon Arridge

In this paper, we present a mathematical model and analysis for a new experimental method [Bureau and al., arXiv:2409.13901, 2024] for effective sound velocity estimation in medical ultrasound imaging. We perform a detailed analysis of the…

Analysis of PDEs · Mathematics 2025-05-13 Josselin Garnier , Laure Giovangigli , Quentin Goepfert , Pierre Millien

Several hybrid tomographic methods utilizing ultrasound modulation have been introduced lately. Success of these methods hinges on the feasibility of focusing ultrasound waves at an arbitrary point of interest. Such a focusing, however, is…

Analysis of PDEs · Mathematics 2010-10-11 Peter Kuchment , Leonid Kunyansky

We propose a hybrid diffusion-based augmentation framework to overcome the critical challenge of ultrasound data augmentation in breast ultrasound (BUS) datasets. Unlike conventional diffusion-based augmentations, our approach improves…

Image and Video Processing · Electrical Eng. & Systems 2026-03-31 Farhan Fuad Abir , Sanjeda Sara Jennifer , Niloofar Yousefi , Laura J. Brattain

PET imaging is widely employed for observing biological metabolic activities within the human body. However, numerous benign conditions can cause increased uptake of radiopharmaceuticals, confounding differentiation from malignant tumors.…

Image and Video Processing · Electrical Eng. & Systems 2024-10-31 Ran Hong , Yuxia Huang , Lei Liu , Zhonghui Wu , Bingxuan Li , Xuemei Wang , Qiegen Liu

Ultrasound Computed Tomography (USCT) provides a radiation-free option for high-resolution clinical imaging. Despite its potential, the computationally intensive Full Waveform Inversion (FWI) required for tissue property reconstruction…

Image and Video Processing · Electrical Eng. & Systems 2023-12-27 Zhijun Zeng , Yihang Zheng , Youjia Zheng , Yubing Li , Zuoqiang Shi , He Sun

Beamforming in ultrasound imaging has significant impact on the quality of the final image, controlling its resolution and contrast. Despite its low spatial resolution and contrast, delay-and-sum is still extensively used nowadays in…

Computer Vision and Pattern Recognition · Computer Science 2016-05-20 Teodora Szasz , Adrian Basarab , Denis Kouamé

This is the first article in a series of two dealing with a matrix approach for aberration quantification and correction in ultrasound imaging. Advanced synthetic beamforming relies on a double focusing operation at transmission and…

Applied Physics · Physics 2022-12-06 William Lambert , Justine Robin , Laura A. Cobus , Mathias Fink , Alexandre Aubry

Computed tomography (CT) is widely used in scientific imaging systems such as synchrotron and laboratory-based nano-CT, but acquiring full-view sinograms requires high radiation dose and long scan times. Sparse-view CT reduces this burden…

Image and Video Processing · Electrical Eng. & Systems 2026-02-10 Jiaze E , Srutarshi Banerjee , Tekin Bicer , Guannan Wang , Yanfu Zhang , Bin Ren

Ultrafast ultrasound localization microscopy (ULM), which has shown promising results in microvascular imaging, overcomes the typical trade-off between resolution and penetration depth. Combining ultrasound contrast agents and high frame…

Signal Processing · Electrical Eng. & Systems 2024-07-02 A. N. Madhavanunni , Niya Mariam Benoy , Mahesh Raveendranatha Panicker , Himanshu Shekhar

Ultrasound offers a safe, cost-effective, and widely accessible technology for fetal brain imaging, making it especially suitable for routine clinical use. However, it suffers from view-dependent artifacts, operator variability, and a…

Image and Video Processing · Electrical Eng. & Systems 2026-01-13 Mohammad Khateri , Morteza Ghahremani , Sergio Valencia , Camilo Jaimes , Alejandra Sierra , Jussi Tohka , P. Ellen Grant , Davood Karimi

Digital Breast Tomosynthesis (DBT) provides an insight into the fine details of normal fibroglandular tissues and abnormal lesions by reconstructing a pseudo-3D image of the breast. In this respect, DBT overcomes a major limitation of…

Computer Vision and Pattern Recognition · Computer Science 2013-07-24 Guang Yang , John H. Hipwell , David J. Hawkes , Simon R. Arridge

Ultrasound images formed by delay-and-sum beamforming are plagued by artifacts that only clear up after compounding many transmissions. Some prior works pose imaging as an inverse problem. This approach can yield high image quality with few…

Signal Processing · Electrical Eng. & Systems 2024-07-03 Vincent van de Schaft , Oisín Nolan , Ruud J. G. van Sloun

In order to realize fast OCT-systems with adjustable line rate, we investigate averaging of image data from an FDML based MHz-OCT-system. The line rate can be reduced in software and traded in for increased system sensitivity and image…

We present a novel approach to transcranial ultrasound computed tomography that utilizes normalizing flows to improve the speed of imaging and provide Bayesian uncertainty quantification. Our method combines physics-informed methods and…

Image and Video Processing · Electrical Eng. & Systems 2023-03-08 Rafael Orozco , Mathias Louboutin , Ali Siahkoohi , Gabrio Rizzuti , Tristan van Leeuwen , Felix Herrmann