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The challenge of imaging low-density objects in an electron microscope without causing beam damage is significant in modern TEM. This is especially true for life science imaging, where the sample, rather than the instrument, still…

Optics · Physics 2025-01-29 Francisco Vega Ibáñez , Jo Verbeeck

A transmission electron microscope that takes advantage of superconducting quantum circuitry is proposed. The microscope is designed to improve image contrast of radiation-sensitive weak phase objects, in particular biological specimens.…

Quantum Physics · Physics 2015-05-27 Hiroshi Okamoto

We propose a Zernike phase contrast electron microscope that uses an intense laser focus to convert a phase image into a visible image. We present the relativistic quantum theory of the phase shift caused by the laser-electron-interaction,…

Instrumentation and Detectors · Physics 2010-09-10 Holger Mueller , Jian Jin , Radostin Danev , John Spence , Howard Padmore , Robert M. Glaeser

We show that quantum computational imaging is advantageous in the setting of low-dose electron microscopy of beam-sensitive specimens. Two qudits placed near the electron beam enable full transfer of quantum information between the electron…

Quantum Physics · Physics 2026-04-14 Hiroshi Okamoto

We use a quantum sensor based on thermal Rydberg atoms to receive data encoded in electromagnetic fields in the extreme electrically small regime, with a sensing volume over $10^7$ times smaller than the cube of the electric field…

Atomic Physics · Physics 2018-09-19 Kevin C. Cox , David H. Meyer , Fredrik K. Fatemi , Paul D. Kunz

The last two decades experimentally affirmed the quantum nature of free electron wavepackets by the rapid development of transmission electron microscopes into ultrafast, quantum-coherent systems. In particular, ultrafast electron pulses…

Optics · Physics 2022-09-30 Roy Shiloh , Tomas Chlouba , Peter Hommelhoff

Important recent advances in transmission electron microscopy instrumentation and capabilities have made it indispensable for atomic-scale materials characterization. At the same time, the availability of two-dimensional materials has…

Materials Science · Physics 2021-05-04 Toma Susi , Jannik C. Meyer , Jani Kotakoski

Laser-based preparation, manipulation, and readout of the states of quantum particles has become a powerful research tool that has enabled the most precise measurements of time, fundamental constants, and electromagnetic fields. Laser…

Quantum Physics · Physics 2018-12-12 O. Schwartz , J. J. Axelrod , S. L. Campbell , C. Turnbaugh , R. M. Glaeser , H. Müller

Phase estimation is one of the most important facets of quantum metrology, with applications in sensing, microscopy, and quantum computation. When estimating a phase shift in a lossy medium, there is an upper bound on the attainable…

Quantum Physics · Physics 2024-11-26 Stewart A. Koppell , Mark A. Kasevich

We consider the physical limitations imposed on the information content of an image by the wave and quantum nature of light, when the image is obtained by illuminating a reflecting or transmitting planar object by natural---i.e., fully…

Quantum Physics · Physics 2014-02-13 Lev B Levitin , Tommaso Toffoli

One of the astounding consequences of quantum mechanics is that it allows the detection of a target using an incident probe, with only a low probability of interaction of the probe and the target. This 'quantum weirdness' could be applied…

Electron and x-ray microscopes allow one to image the entire, unlabeled structure of hydrated materials at a resolution well beyond what visible light microscopes can achieve. However, both approaches involve ionizing radiation, so that…

Applied Physics · Physics 2020-04-22 Ming Du , Chris Jacobsen

We show that radiation damage to unstained biological specimens is not an intractable problem in electron microscopy. When a structural hypothesis of a specimen is available, quantum mechanical principles allow us to verify the hypothesis…

Quantum Physics · Physics 2015-07-01 Hiroshi Okamoto , Tatiana Latychevskaia , Hans-Werner Fink

We propose a simple design of a quantum electron microscope that ``queries'' a beam-sensitive phase object, such as a biological specimen, as part of quantum computation. Lower quantum query complexity, not the time complexity, of a quantum…

Quantum Physics · Physics 2026-04-15 Hiroshi Okamoto

The field of quantum metrology seeks to apply quantum techniques and/or resources to classical sensing approaches with the goal of enhancing the precision in the estimation of a parameter beyond what can be achieved with classical…

Zernike phase-contrast imaging is unique among imaging techniques in that it enables the upper limit of Fisher information allowed by quantum mechanics. Here we show that, in a departure from an ideal setting, using an incident beam of…

Optics · Physics 2026-02-17 Christian Dwyer , David M. Paganin

Feynman once asked physicists to build better electron microscopes to be able to watch biology at work. While electron microscopes can now provide atomic resolution, electron beam induced specimen damage precludes high resolution imaging of…

Instrumentation and Detectors · Physics 2016-12-16 Thomas Juffmann , Stewart A. Koppell , Brannon B. Klopfer , Colin Ophus , Robert Glaeser , Mark A. Kasevich

We describe an interference setup which seems to defy the No-Communication theorem. We discuss its potential flaw and derive a relation implied by quantum mechanics that limits the size of the detector given the particle's state width.

General Physics · Physics 2022-12-21 Filippo Fratini

The major resolution-limiting factor in cryoelectron microscopy of unstained biological specimens is radiation damage by the very electrons that are used to probe the specimen structure. To address this problem, an electron microscopy…

Quantum Physics · Physics 2015-06-18 Hiroshi Okamoto
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