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This article considers the impact of different thresholding methods to the Nearest Shrunken Centroid algorithm, which is popularly referred as the Prediction Analysis of Microarrays (PAM) for high-dimensional classification. PAM uses soft…

Machine Learning · Statistics 2025-01-03 Mohammad Omar Sahtout , Haiyan Wang , Santosh Ghimire

Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, most deep learning-based objective outcome prediction and…

Computer Vision and Pattern Recognition · Computer Science 2020-09-04 Richard J. Chen , Ming Y. Lu , Jingwen Wang , Drew F. K. Williamson , Scott J. Rodig , Neal I. Lindeman , Faisal Mahmood

Acute lymphoblastic leukemia is the most frequent pediatric cancer. Approximately two third of survivors develop one or more health complications known as late adverse effects following their treatments. The existing measures offered to…

Background: Embedded feature selection in high-dimensional data with very small sample sizes requires optimized hyperparameters for the model building process. For this hyperparameter optimization, nested cross-validation must be applied to…

Machine Learning · Computer Science 2022-09-13 Sigrun May , Sven Hartmann , Frank Klawonn

Despite the significant potential of Foundation Models (FMs) in medical imaging, their application to prognosis prediction remains challenging due to data scarcity, class imbalance, and task complexity, which limit their clinical adoption.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-16 Filippo Ruffini , Elena Mulero Ayllon , Linlin Shen , Paolo Soda , Valerio Guarrasi

Artificial intelligence has reshaped medical imaging, yet the use of AI on clinical data for prospective decision support remains limited. We study pre-operative prediction of clinically meaningful improvement in chronic rhinosinusitis…

Machine Learning · Computer Science 2026-01-23 Sayeed Shafayet Chowdhury , Snehasis Mukhopadhyay , Shiaofen Fang , Vijay R. Ramakrishnan

Purpose: To develop a novel deep-learning model that integrates radiomics analysis in a multi-dimensional feature fusion workflow for glioblastoma (GBM) post-resection survival prediction. Methods: A cohort of 235 GBM patients with complete…

Medical Physics · Physics 2022-03-14 Zongsheng Hu , Zhenyu Yang , Haozhao Zhang , Eugene Vaios , Kyle Lafata , Fang-Fang Yin , Chunhao Wang

The conditional survival function of a time-to-event outcome subject to censoring and truncation is a common target of estimation in survival analysis. This parameter may be of scientific interest and also often appears as a nuisance in…

Methodology · Statistics 2024-08-20 Charles J. Wolock , Peter B. Gilbert , Noah Simon , Marco Carone

Signal integrity (SI) analysis in printed circuit board (PCB) interconnects faces increasing complexity due to diverse integrated circuit (IC) buffer technologies, varying operating conditions, and manufacturing tolerances. Existing machine…

Signal Processing · Electrical Eng. & Systems 2026-05-19 Julian Withöft , Werner John , Emre Ecik , Ralf Brüning , Jürgen Götze

While machine learning is currently transforming the field of histopathology, the domain lacks a comprehensive evaluation of state-of-the-art models based on essential but complementary quality requirements beyond a mere classification…

Image and Video Processing · Electrical Eng. & Systems 2023-05-11 Maximilian Springenberg , Annika Frommholz , Markus Wenzel , Eva Weicken , Jackie Ma , Nils Strodthoff

Brain stroke is a leading cause of mortality and long-term disability worldwide, underscoring the need for precise and rapid prediction techniques. Computed Tomography (CT) scan is considered one of the most effective methods for diagnosing…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Md. Sabbir Hossen , Eshat Ahmed Shuvo , Shibbir Ahmed Arif , Pabon Shaha , Anichur Rahman , Md. Saiduzzaman , Fahmid Al Farid , Hezerul Abdul Karim , Abu Saleh Musa Miah

Risk prediction is central to both clinical medicine and public health. While many machine learning models have been developed to predict mortality, they are rarely applied in the clinical literature, where classification tasks typically…

Machine Learning · Statistics 2017-12-05 Maggie Makar , Marzyeh Ghassemi , David Cutler , Ziad Obermeyer

Designing proper treatment plans to manage diabetes requires health practitioners to pay heed to the individuals remaining life along with the comorbidities affecting them. Older adults with Type 2 Diabetes Mellitus (T2DM) are prone to…

Machine Learning · Computer Science 2024-02-20 Ruchika Desure , Gutha Jaya Krishna

Knee osteoporosis weakens the bone tissue in the knee joint, increasing fracture risk. Early detection through X-ray images enables timely intervention and improved patient outcomes. While some researchers have focused on diagnosing knee…

Image and Video Processing · Electrical Eng. & Systems 2024-12-13 Ayesha Siddiqua , Rakibul Hasan , Anichur Rahman , Abu Saleh Musa Miah

Hospital Readmissions within 30 days after discharge following Coronary Artery Bypass Graft (CABG) Surgery are substantial contributors to healthcare costs. Many predictive models were developed to identify risk factors for readmissions.…

Machine Learning · Computer Science 2018-12-04 Ramesh B. Manyam , Yanqing Zhang , William B. Keeling , Jose Binongo , Michael Kayatta , Seth Carter

Machine unlearning (MU) aims to remove the influence of particular data points from the learnable parameters of a trained machine learning model. This is a crucial capability in light of data privacy requirements, trustworthiness, and…

Machine Learning · Computer Science 2025-07-01 Xavier F. Cadet , Anastasia Borovykh , Mohammad Malekzadeh , Sara Ahmadi-Abhari , Hamed Haddadi

Clinical machine learning faces a critical dilemma in high-stakes medical applications: algorithms achieving optimal diagnostic performance typically sacrifice the interpretability essential for physician decision-making, while…

Machine Learning · Computer Science 2025-09-23 Xiuqi Ge , Zhibo Yao , Yaosong Du

Quick and accurate medical diagnosis is crucial for the successful treatment of a disease. Using machine learning algorithms, we have built two models to predict a hematologic disease, based on laboratory blood test results. In one…

Machine Learning · Statistics 2020-06-09 Gregor Gunčar , Matjaž Kukar , Mateja Notar , Miran Brvar , Peter Černelč , Manca Notar , Marko Notar

Electronic health records represent a holistic overview of patients' trajectories. Their increasing availability has fueled new hopes to leverage them and develop accurate risk prediction models for a wide range of diseases. Given the…

Deep Learning (DL) has advanced various fields by extracting complex patterns from large datasets. However, the computational demands of DL models pose environmental and resource challenges. Deep shift neural networks (DSNNs) offer a…

Machine Learning · Computer Science 2024-04-05 Leona Hennig , Tanja Tornede , Marius Lindauer