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Complex models in physics, biology, economics, and engineering are often sloppy, meaning that the model parameters are not well determined by the model predictions for collective behavior. Many parameter combinations can vary over decades…

Statistical Mechanics · Physics 2022-09-26 Katherine N. Quinn , Michael C. Abbott , Mark K. Transtrum , Benjamin B. Machta , James P. Sethna

Large scale models of physical phenomena demand the development of new statistical and computational tools in order to be effective. Many such models are `sloppy', i.e., exhibit behavior controlled by a relatively small number of parameter…

Dynamic models of biochemical networks typically consist of sets of non-linear ordinary differential equations involving states (concentrations or amounts of the components of the network) and parameters describing the reaction kinetics.…

Molecular Networks · Quantitative Biology 2014-03-07 Oana-Teodora Chis , Julio R. Banga , Eva Balsa-Canto

The use of mathematical models in the sciences often involves the estimation of unknown parameter values from data. Sloppiness provides information about the uncertainty of this task. In this paper, we develop a precise mathematical…

Metric Geometry · Mathematics 2018-03-15 Emilie Dufresne , Heather A. Harrington , Dhruva V. Raman

We use information geometry, in which the local distance between models measures their distinguishability from data, to quantify the flow of information under the renormalization group. We show that information about relevant parameters is…

Statistical Mechanics · Physics 2018-12-05 Archishman Raju , Benjamin B. Machta , James P. Sethna

Bifurcation analysis collects techniques for characterizing the dependence of certain classes of solutions of a dynamical system on variations in problem parameters. Common solution classes of interest include equilibria and periodic…

Dynamical Systems · Mathematics 2025-11-05 Harry Dankowicz , Jan Sieber

We provide a short introduction to the field of topological data analysis and discuss its possible relevance for the study of complex systems. Topological data analysis provides a set of tools to characterise the shape of data, in terms of…

Data Analysis, Statistics and Probability · Physics 2018-12-05 Vsevolod Salnikov , Daniele Cassese , Renaud Lambiotte

Quantitative computational models play an increasingly important role in modern biology. Such models typically involve many free parameters, and assigning their values is often a substantial obstacle to model development. Directly measuring…

Quantitative Methods · Quantitative Biology 2011-11-09 Ryan N. Gutenkunst , Joshua J. Waterfall , Fergal P. Casey , Kevin S. Brown , Christopher R. Myers , James P. Sethna

We treat the problem of characterizing in a systematic way the qualitative features of two-dimensional dynamical systems. To that end, we construct a representation of the topological features of phase portraits by means of diagrams that…

Chaotic Dynamics · Physics 2018-06-29 Javier Roulet , Gabriel B. Mindlin

We rigorously prove the bifurcation of slow-moving pattern interfaces with general direction in a two-dimensional Swift-Hohenberg-type model close to a Turing instability for a large class of nonlinearities. These interfaces describe the…

Analysis of PDEs · Mathematics 2026-04-13 Bastian Hilder , Jonas Jansen

We extend and apply a recently developed approach to the study of dynamic bifurcations in PDEs based on the geometric blow-up method. We show that this approach, which has so far only been applied to study a dynamic Turing bifurcation in a…

Dynamical Systems · Mathematics 2023-02-14 Samuel Jelbart , Christian Kuehn

Information theoretic geometry near critical points in classical and quantum systems is well understood for exactly solvable systems. Here we show that renormalization group flow equations can be used to construct the information metric and…

Statistical Mechanics · Physics 2018-11-21 Reevu Maity , Subhash Mahapatra , Tapobrata Sarkar

The double Hamiltonian Hopf bifurcation is studied, i.e. a generic two-parametric unfolding of a smooth Hamiltonian system with four degrees of freedom which has at the critical value of parameters the equilibrium with two pairs of double…

Dynamical Systems · Mathematics 2025-06-02 L. M. Lerman , R. Mazrooei-Sebdani , N. E. Kulagin

Network architecture design is very important for the optimization of industrial networks. The type of network architecture can be divided into small-scale network and large-scale network according to its scale. Graph theory is an efficient…

Social and Information Networks · Computer Science 2022-09-20 Chao Dong , Xiaoxiong Xiong , Qiulin Xue , Zhengzhen Zhang , Kai Niu , Ping Zhang

The structure of real-world networks is usually difficult to characterize owing to the variation of topological scales, the nondyadic complex interactions, and the fluctuations in the network. We aim to address these problems by introducing…

Social and Information Networks · Computer Science 2019-09-25 Quoc Hoan Tran , Van Tuan Vo , Yoshihiko Hasegawa

The introduction of a metric onto the space of parameters in models in Statistical Mechanics and beyond gives an alternative perspective on their phase structure. In such a geometrization, the scalar curvature, R, plays a central role. A…

Statistical Mechanics · Physics 2009-11-10 W. Janke , D. A. Johnston , R. Kenna

This work proposes a data-driven approach for bifurcation analysis in nonlinear systems when the governing differential equations are not available. Specifically, regularized regression with barrier terms is used to learn a homeomorphism…

Systems and Control · Electrical Eng. & Systems 2023-12-12 Wentao Tang

Scientists use mathematical modelling to understand and predict the properties of complex physical systems. In highly parameterised models there often exist relationships between parameters over which model predictions are identical, or…

Data Analysis, Statistics and Probability · Physics 2017-03-24 Dhruva V. Raman , James Anderson , Antonis Papachristodoulou

We explore the relationship among model fidelity, experimental design, and parameter estimation in sloppy models. We show that the approximate nature of mathematical models poses challenges for experimental design in sloppy models. In many…

Quantitative Methods · Quantitative Biology 2017-02-08 Andrew White , Malachi Tolman , Howard D. Thames , Hubert Rodney Withers , Kathy A. Mason , Mark K. Transtrum

Networks serve as a tool used to examine the large-scale connectivity patterns in complex systems. Modelling their generative mechanism nonparametrically is often based on step-functions, such as the stochastic block models. These models…

Methodology · Statistics 2024-01-11 Arthur Verdeyme , Sofia C. Olhede
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