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Advances in generative artificial intelligence are transforming how metal-organic frameworks (MOFs) are designed and discovered. This Perspective introduces the shift from laborious enumeration of MOF candidates to generative approaches…

Recent advances in spatial omics technologies have revolutionized our ability to study biological systems with unprecedented resolution. By preserving the spatial context of molecular measurements, these methods enable comprehensive mapping…

Quantitative Methods · Quantitative Biology 2025-09-18 Zhiwei Fan , Tiangang Wang , Kexin Huang , Binwu Ying , Xiaobo Zhou

Machine Learning (ML) systems are capable of reproducing and often amplifying undesired biases. This puts emphasis on the importance of operating under practices that enable the study and understanding of the intrinsic characteristics of ML…

Artificial Intelligence · Computer Science 2025-12-01 Mayra Russo , Maria-Esther Vidal

With the increasing interplay between experimental and computational approaches at multiple length scales, new research directions are emerging in materials science and computational mechanics. Such cooperative interactions find many…

Materials Science · Physics 2016-01-12 Rémi Dingreville , Richard A. Karnesky , Guillaume Puel , Jean-Hubert Schmitt

A global optimization framework, acronymed COMBEO (Change OfMeasure Based Evolutionary Optimization), is proposed. An important aspect in the development is a set of derivative-free additive directional terms obtainable through a change of…

Methodology · Statistics 2014-11-10 Saikat Sarkar , Debasish Roy

Activity and autonomous motion are fundamental in living and engineering systems. This has stimulated the new field of active matter in recent years, which focuses on the physical aspects of propulsion mechanisms, and on motility-induced…

Molecular-scale computation is crucial for smart materials and nanoscale devices, yet creating single-molecule systems capable of complex computations remains challenging. We present a theoretical framework for a single-molecule computer…

Statistical Mechanics · Physics 2024-10-01 Zhongmin Zhang , Zhiyue Lu

Here we highlight recent progress in the field of computational chemistry of nanoporous materials, focusing on methods and studies that address the extraordinary dynamic nature of these systems: the high flexibility of their frameworks, the…

Chemical Physics · Physics 2018-06-29 Guillaume Fraux , François-Xavier Coudert

Superconducting materials find applications in a rapidly growing number of technological areas, and searching for novel superconductors continues to be a major scientific task. However, the steady increase in the complexity of candidate…

Superconductivity · Physics 2019-12-20 J. Yuan , V. Stanev , C. Gao , I. Takeuchi , K. Jin

Materials with bespoke properties have long been identified by computational searches, and their experimental realisation is now coming within reach through autonomous laboratories. Scattering experiments are central to verifying the atomic…

Modeling and simulation (M&S) has revolutionized the way modern engineered products are designed, tested and evaluated. Yet modeling and simulation is much less frequently applied in the study of natural biological and active matter…

Subcellular Processes · Quantitative Biology 2021-05-07 Endre T. Somogyi , Jeffery Coulter , Fanbo Sun , Herbert M. Sauro , James A. Glazier

Structurally and chemically complex materials such as amorphous metallosilicates underpin major catalytic and separation technologies, yet their intrinsic complexity challenges reliable atomistic modeling under realistic conditions.…

Growth in computational materials science and initiatives such as the Materials Genome Initiative (MGI) and the European Materials Modelling Council (EMMC) has motivated the development and application of ontologies. A key factor has been…

Digital Libraries · Computer Science 2024-03-05 Scott McClellan , Yuan An , Xintong Zhao , Xia Lin , Jane Greenberg

Foundation Models (FM) have increasingly drawn the attention of researchers due to their scalability and generalization across diverse tasks. Inspired by the success of FMs and the principles that have driven advancements in Large Language…

Computer Vision and Pattern Recognition · Computer Science 2025-02-26 Mohammadreza Baharani , Ghazal Alinezhad Noghre , Armin Danesh Pazho , Gabriel Maldonado , Hamed Tabkhi

Artificial intelligence has demonstrated immense potential in scientific research. Within molecular science, it is revolutionizing the traditional computer-aided paradigm, ushering in a new era of deep learning. With recent progress in…

Biomolecules · Quantitative Biology 2024-03-22 Yi Xiao , Xiangxin Zhou , Qiang Liu , Liang Wang

Metal-organic frameworks (MOFs) have been widely investigated for challenging catalytic transformations due to their well-defined structures and high degree of synthetic tunability. These features, at least in principle, make MOFs ideally…

Materials Science · Physics 2021-10-19 Andrew S. Rosen , Justin M. Notestein , Randall Q. Snurr

This paper systematically reviews the research progress and application prospects of machine learning technologies in the field of polymer materials. Currently, machine learning methods are developing rapidly in polymer material research;…

Materials Science · Physics 2025-10-31 Hongtao Guo Shuai Li Shu Li

Computational design problems arise in a number of settings, from synthetic biology to computer architectures. In this paper, we aim to solve data-driven model-based optimization (MBO) problems, where the goal is to find a design input that…

Machine Learning · Computer Science 2021-07-15 Brandon Trabucco , Aviral Kumar , Xinyang Geng , Sergey Levine

The high cost and data scarcity in scientific exploration have motivated the use of large language models (LLMs) as knowledge-driven components in Bayesian optimization (BO). However, existing approaches typically embed LLMs directly into…