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Manual medical image segmentation is subjective and suffers from annotator-related bias, which can be mimicked or amplified by deep learning methods. Recently, researchers have suggested that such bias is the combination of the annotator…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Zehui Liao , Yutong Xie , Shishuai Hu , Yong Xia

In medical imaging, inter-observer variability among radiologists often introduces label uncertainty, particularly in modalities where visual interpretation is subjective. Lung ultrasound (LUS) is a prime example-it frequently presents a…

Trustworthy artificial intelligence (AI) is essential in healthcare, particularly for high-stakes tasks like medical image segmentation. Explainable AI and uncertainty quantification significantly enhance AI reliability by addressing key…

Medical imaging only indirectly measures the molecular identity of the tissue within each voxel, which often produces only ambiguous image evidence for target measures of interest, like semantic segmentation. This diversity and the…

A major challenge in the segmentation of medical images is the large inter- and intra-observer variability in annotations provided by multiple experts. To address this challenge, we propose a novel method for multi-expert prediction using…

Image and Video Processing · Electrical Eng. & Systems 2023-06-16 Tomer Amit , Shmuel Shichrur , Tal Shaharabany , Lior Wolf

Deep learning-based object detectors have achieved impressive performance in microscopy imaging, yet their confidence estimates often lack calibration, limiting their reliability for biomedical applications. In this work, we introduce a new…

Computer Vision and Pattern Recognition · Computer Science 2026-02-02 Francesco Campi , Lucrezia Tondo , Ekin Karabati , Johannes Betge , Marie Piraud

Precise delineation of multiple organs or abnormal regions in the human body from medical images plays an essential role in computer-aided diagnosis, surgical simulation, image-guided interventions, and especially in radiotherapy treatment…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Shiman Li , Haoran Wang , Yucong Meng , Chenxi Zhang , Zhijian Song

There exists a large number of datasets for organ segmentation, which are partially annotated, and sequentially constructed. A typical dataset is constructed at a certain time by curating medical images and annotating the organs of…

Computer Vision and Pattern Recognition · Computer Science 2023-05-09 Pengbo Liu , Li Xiao , S. Kevin Zhou

Interpretability is essential in medical imaging to ensure that clinicians can comprehend and trust artificial intelligence models. In this paper, we propose a novel interpretable approach that combines attribute regularization of the…

Image and Video Processing · Electrical Eng. & Systems 2023-12-15 Maxime Di Folco , Cosmin I. Bercea , Julia A. Schnabel

Variability in medical image segmentation, arising from annotator preferences, expertise, and their choice of tools, has been well documented. While the majority of multi-annotator segmentation approaches focus on modeling…

Computer Vision and Pattern Recognition · Computer Science 2024-08-07 Kumar Abhishek , Jeremy Kawahara , Ghassan Hamarneh

Quantifying aleatoric uncertainty in medical image segmentation is critical since it is a reflection of the natural variability observed among expert annotators. A conventional approach is to model the segmentation distribution using the…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Phi Van Nguyen , Ngoc Huynh Trinh , Duy Minh Lam Nguyen , Phu Loc Nguyen , Quoc Long Tran

Lesion detection in brain Magnetic Resonance Images (MRI) remains a challenging task. State-of-the-art approaches are mostly based on supervised learning making use of large annotated datasets. Human beings, on the other hand, even…

Computer Vision and Pattern Recognition · Computer Science 2018-06-14 Xiaoran Chen , Ender Konukoglu

Multi-rater medical image segmentation captures the inherent ambiguity of clinical interpretation, where diagnostic boundaries vary across experts and imaging devices. Existing approaches often reduce this diversity to consensus labels or…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Sanaz Karimijafarbigloo , Armin Khosravi , Alireza Kheyrkhah , Reza Azad , Mauricio Reyes , Dorit Merhof

Multiview latent-variable models provide a fundamental framework for discrete data analysis, with applications to latent structure models, topic models, and mixtures of product distributions. In the discrete setting, the joint distribution…

Methodology · Statistics 2026-05-26 Runshi Tang , Julien Chhor , Olga Klopp , Alexandre B. Tsybakov , Anru R. Zhang

We propose a hierarchically structured variational inference model for accurately disentangling observable evidence of disease (e.g. brain lesions or atrophy) from subject-specific anatomy in brain MRIs. With flexible, partially…

Computer Vision and Pattern Recognition · Computer Science 2022-11-17 Anjun Hu , Jean-Pierre R. Falet , Brennan S. Nichyporuk , Changjian Shui , Douglas L. Arnold , Sotirios A. Tsaftaris , Tal Arbel

Uncertainty estimation is important for interpreting the trustworthiness of machine learning models in many applications. This is especially critical in the data-driven active learning setting where the goal is to achieve a certain accuracy…

Computer Vision and Pattern Recognition · Computer Science 2020-07-14 Bo Li , Tommy Sonne Alstrøm

Uncertainty of labels in clinical data resulting from intra-observer variability can have direct impact on the reliability of assessments made by deep neural networks. In this paper, we propose a method for modelling such uncertainty in the…

The annotation of disease severity for medical image datasets often relies on collaborative decisions from multiple human graders. The intra-observer variability derived from individual differences always persists in this process, yet the…

Computer Vision and Pattern Recognition · Computer Science 2022-05-03 Chi Liu , Zongyuan Ge , Mingguang He , Xiaotong Han

Deep Learning models are easily disturbed by variations in the input images that were not seen during training, resulting in unpredictable behaviours. Such Out-of-Distribution (OOD) images represent a significant challenge in the context of…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Benjamin Lambert , Florence Forbes , Senan Doyle , Alan Tucholka , Michel Dojat

Causal representation learning has emerged as the center of action in causal machine learning research. In particular, multi-domain datasets present a natural opportunity for showcasing the advantages of causal representation learning over…

Machine Learning · Computer Science 2023-12-12 Kartik Ahuja , Amin Mansouri , Yixin Wang