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Introduction: Machine learning (ML) has been extremely successful in identifying key features from high-dimensional datasets and executing complicated tasks with human expert levels of accuracy or greater. Methods: We summarize and…

Machine learning methods exploiting multi-parametric biomarkers, especially based on neuroimaging, have huge potential to improve early diagnosis of dementia and to predict which individuals are at-risk of developing dementia. To benchmark…

Machine Learning · Computer Science 2022-02-21 Esther E. Bron , Stefan Klein , Annika Reinke , Janne M. Papma , Lena Maier-Hein , Daniel C. Alexander , Neil P. Oxtoby

Machine learning has shown promise for automatic detection of Alzheimer's disease (AD) through speech; however, efforts are hampered by a scarcity of data, especially in languages other than English. We propose a method to learn a…

Computation and Language · Computer Science 2019-06-04 Bai Li , Yi-Te Hsu , Frank Rudzicz

Missing data represents a fundamental challenge in machine learning applications, often reducing model performance and reliability. This problem is particularly acute in fields like bioinformatics and clinical machine learning, where…

Machine Learning · Computer Science 2025-09-04 Fatemeh Azad , Zoran Bosnić , Matjaž Kukar

Joint models are used in ageing studies to investigate the association between longitudinal markers and a time-to-event, and have been extended to multiple markers and/or competing risks. The competing risk of death must be considered in…

We jointly model longitudinal values of a psychometric test and diagnosis of dementia. The model is based on a continuous-time latent process representing cognitive ability. The link between the latent process and the observations is…

Statistics Theory · Mathematics 2007-06-13 Julien Ganiayre , Daniel Commenges , Luc Letenneur

How will my face look when I get older? Or, for a more challenging question: How will my brain look when I get older? To answer this question one must devise (and learn from data) a multivariate auto-regressive function which given an image…

Image and Video Processing · Electrical Eng. & Systems 2021-10-01 Tian Xia , Agisilaos Chartsias , Chengjia Wang , Sotirios A. Tsaftaris

Given genetic variations and various phenotypical traits, such as Magnetic Resonance Imaging (MRI) features, we consider two important and related tasks in biomedical research: i)to select genetic and phenotypical markers for disease…

Machine Learning · Computer Science 2013-10-17 Shandian Zhe , Zenglin Xu , Yuan Qi

Missing values are a fundamental problem in data science. Many datasets have missing values that must be properly handled because the way missing values are treated can have large impact on the resulting machine learning model. In medical…

Machine Learning · Computer Science 2023-04-25 Zhi Chen , Sarah Tan , Urszula Chajewska , Cynthia Rudin , Rich Caruana

Ecological Momentary Assessments (EMA) capture real-time thoughts and behaviors in natural settings, producing rich longitudinal data for statistical and physiological analyses. However, the robustness of these analyses can be compromised…

Methodology · Statistics 2023-11-21 Yiheng Wei , Donald Hedeker

Medical records often consist of different modalities, such as images, text, and tabular information. Integrating all modalities offers a holistic view of a patient's condition, while analyzing them longitudinally provides a better…

Computer Vision and Pattern Recognition · Computer Science 2024-03-25 Boqi Chen , Junier Oliva , Marc Niethammer

The estimation of missing input vector elements in real time processing applications requires a system that possesses the knowledge of certain characteristics such as correlations between variables, which are inherent in the input space.…

Applications · Statistics 2007-05-23 Fulufhelo V. Nelwamondo , Shakir Mohamed , Tshilidzi Marwala

We propose to learn latent graphical models when data have mixed variables and missing values. This model could be used for further data analysis, including regression, classification, ranking etc. It also could be used for imputing missing…

Methodology · Statistics 2015-11-17 Xiao Li , Jinzhu Jia , Yuan Yao

Handling missing values at test time is challenging for machine learning models, especially when aiming for both high accuracy and interpretability. Established approaches often add bias through imputation or excessive model complexity via…

Machine Learning · Computer Science 2025-05-07 Lena Stempfle , Anton Matsson , Newton Mwai , Fredrik D. Johansson

As the number of dementia patients rises, the need for accurate diagnostic procedures rises as well. Current methods, like using an MRI scan, rely on human input, which can be inaccurate. However, the decision logic behind machine learning…

Image and Video Processing · Electrical Eng. & Systems 2024-06-28 Tyler Morris , Ziming Liu , Longjian Liu , Xiaopeng Zhao

Missing values in multivariate time series data can harm machine learning performance and introduce bias. These gaps arise from sensor malfunctions, blackouts, and human error and are typically addressed by data imputation. Previous work…

Machine Learning · Computer Science 2025-03-04 Mohammad Rafid Ul Islam , Prasad Tadepalli , Alan Fern

Identifying and utilising various biomarkers for tracking Alzheimer's disease (AD) progression have received many recent attentions and enable helping clinicians make the prompt decisions. Traditional progression models focus on extracting…

Machine Learning · Computer Science 2023-11-08 Xulong Wang , Yu Zhang , Menghui Zhou , Tong Liu , Jun Qi , Po Yang

Dementia is a neurodegenerative disease that causes gradual cognitive impairment, which is very common in the world and undergoes a lot of research every year to prevent and cure it. It severely impacts the patient's ability to remember…

This study is based on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset and aims to explore early detection and disease progression in Alzheimer's disease (AD). We employ innovative data preprocessing strategies, including the…

Machine Learning · Computer Science 2024-02-14 Mingyang Li , Hongyu Liu , Yixuan Li , Zejun Wang , Yuan Yuan , Honglin Dai

Collecting and accessing a large amount of medical data is very time-consuming and laborious, not only because it is difficult to find specific patients but also because it is required to resolve the confidentiality of a patient's medical…

Sound · Computer Science 2021-03-04 Junghyun Koo , Jie Hwan Lee , Jaewoo Pyo , Yujin Jo , Kyogu Lee