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Precision medicine involves developing individualized treatment regimes (ITRs) which allow for treatment decisions to be tailored to patient characteristics. Naturally, the identification of the optimal regime, that is, the rule which…

Methodology · Statistics 2025-09-30 Misha Dolmatov , Erica E. M. Moodie , David A. Stephens , Dipankar Bandyopadhyay

Deep learning is typically performed by learning a neural network solely from data in the form of input-output pairs ignoring available domain knowledge. In this work, the Constraint Guided Gradient Descent (CGGD) framework is proposed that…

Artificial Intelligence · Computer Science 2022-06-15 Quinten Van Baelen , Peter Karsmakers

Modeling latent clinical constructs from unconstrained clinical interactions is a unique challenge in affective computing. We present ADAPTS (Agentic Decomposition for Automated Protocol-agnostic Tracking of Symptoms), a framework for…

Artificial Intelligence · Computer Science 2026-05-07 Alexandria K. Vail , Marcelo Cicconet , Katie Aafjes-van Doorn , Ryan Maroney , Marc Aafjes

Recent advances in dynamic treatment regimes (DTRs) facilitate the search for optimal treatments, which are tailored to individuals' specific needs and able to maximize their expected clinical benefits. However, existing algorithms relying…

Machine Learning · Statistics 2024-10-18 Hanwen Ye , Wenzhuo Zhou , Ruoqing Zhu , Annie Qu

Attacks exploiting the innate and the acquired vulnerabilities of human users have posed severe threats to cybersecurity. This work proposes ADVERT, a human-technical solution that generates adaptive visual aids in real-time to prevent…

Human-Computer Interaction · Computer Science 2022-07-12 Linan Huang , Shumeng Jia , Emily Balcetis , Quanyan Zhu

Today, intensity-modulated radiation therapy (IMRT) is one of the methods used to treat brain tumors. In conventional treatment planning methods, after identifying planning target volume (PTV), and organs at risk (OARs), and determining the…

Quantitative Methods · Quantitative Biology 2023-05-15 Mobina Naeemi , Mohamad Reza Esmaeili , Iraj Abedi

This study investigates the applicability of 3D dose predictions from a model trained on one modality to a cross-modality automated planning workflow. Additionally, we explore the impact of integrating a multi-criteria optimizer on adapting…

Medical Physics · Physics 2024-02-26 Gregory Szalkowski , Xuanang Xu , Shiva Das , Pew-Thian Yap , Jun Lian

The Internet of Things has experienced significant growth and has become an integral part of various industries. This expansion has given rise to the Industrial IoT initiative where industries are utilizing IoT technology to enhance…

Machine Learning · Computer Science 2024-06-04 Anomitra Sarkar , Lavanya Vajpayee

An individualized treatment rule (ITR) tailors treatments to a patient's specific characteristics. However, randomized controlled trials (RCTs) are often underpowered to detect the treatment effect heterogeneity needed for reliable ITR…

Methodology · Statistics 2026-04-14 Yuan Bian , Donglin Zeng , Hyun-Joon Yang , Leanne M. Williams , Yuanjia Wang

Individual participant data (IPD) meta-analyses of randomised trials are considered a reliable way to assess participant-level treatment effect modifiers but may not make the best use of the available data. Traditionally, effect modifiers…

Background: Effective use of mobile health technologies requires high participant adherence and retention. However, remote digital health studies often face high attrition and low adherence, potentially introducing bias and limiting…

Quantitative Methods · Quantitative Biology 2025-09-29 Dylan Hamitouche , Youcef Barkat , Deven Parekh , Eva Hammer , David Benrimoh

Medication nonadherence significantly reduces the effectiveness of therapies, yet it remains prevalent among patients. Nonadherence has been linked to adverse outcomes, including increased risks of mortality and hospitalization. Although…

Machine Learning · Computer Science 2024-08-22 Ali Kamrani khodaei , Sina Hajer Ahmadi

Federated learning is a promising paradigm that allows multiple clients to collaboratively train a model without sharing the local data. However, the presence of heterogeneous devices in federated learning, such as mobile phones and IoT…

Machine Learning · Computer Science 2025-09-03 Kai Zhang , Yutong Dai , Hongyi Wang , Eric Xing , Xun Chen , Lichao Sun

Advancements in wearable medical devices in IoT technology are shaping the modern healthcare system. With the emergence of the Internet of Healthcare Things (IoHT), we are witnessing how efficient healthcare services are provided to…

Networking and Internet Architecture · Computer Science 2023-03-28 Fatemeh Mosaiyebzadeh , Seyedamin Pouriyeh , Reza M. Parizi , Quan Z. Sheng , Meng Han , Liang Zhao , Giovanna Sannino , Daniel Macêdo Batista

The development of intelligent tutoring system has greatly influenced the way students learn and practice, which increases their learning efficiency. The intelligent tutoring system must model learners' mastery of the knowledge before…

Machine Learning · Computer Science 2021-05-25 Junhao Zeng , Qingchun Zhang , Ning Xie , Bochun Yang

Personalized treatment outcome prediction based on trial data for small-sample and rare patient groups is critical in precision medicine. However, the costly trial data limit the prediction performance. To address this issue, we propose a…

Machine Learning · Computer Science 2025-10-31 Wenjie Chen , Li Zhuang , Ziying Luo , Yu Liu , Jiahao Wu , Shengcai Liu

An individualized decision rule (IDR) is a decision function that assigns each individual a given treatment based on his/her observed characteristics. Most of the existing works in the literature consider settings with binary or finitely…

Methodology · Statistics 2023-01-31 Hengrui Cai , Chengchun Shi , Rui Song , Wenbin Lu

Body Dysmorphic Disorder (BDD) is a highly prevalent and frequently underdiagnosed condition characterized by persistent, intrusive preoccupations with perceived defects in physical appearance. In this extended analysis, we employ multiple…

Machine Learning · Computer Science 2025-03-17 Omar Costilla-Reyes , Morgan Talbot

Accurate prediction of the need for invasive mechanical ventilation (IMV) in intensive care units (ICUs) patients is crucial for timely interventions and resource allocation. However, variability in patient populations, clinical practices,…

Machine Learning · Computer Science 2026-01-28 Xiaolei Lu , Shamim Nemati

We present an operational component of a real-world patient triage system. Given a specific patient presentation, the system is able to assess the level of medical urgency and issue the most appropriate recommendation in terms of best point…

Computation and Language · Computer Science 2018-10-01 Ivan Girardi , Pengfei Ji , An-phi Nguyen , Nora Hollenstein , Adam Ivankay , Lorenz Kuhn , Chiara Marchiori , Ce Zhang