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Cell-free DNA (cfDNA) analysis is a powerful, minimally invasive tool for monitoring disease progression, treatment response, and early detection. A major challenge, however, is accurately determining the tissue of origin, especially in…

Genomics · Quantitative Biology 2025-06-03 Keng-Jung Lee , Dharanya Sampath , Konstantinos Mavrommatis

With the development of gene sequencing technology, an explosive growth of gene data has been witnessed. And the storage of gene data has become an important issue. Traditional gene data compression methods rely on general software like…

Machine Learning · Computer Science 2023-02-01 Zhanbei Cui , Yu Liao , Tongda Xu , Yan Wang

Fine-tuning pre-trained models provides significant advantages in downstream performance. The ubiquitous nature of pre-trained models such as BERT and its derivatives in natural language processing has also led to a proliferation of…

Computation and Language · Computer Science 2024-05-06 Thennal D K , Ganesh Nathan , Suchithra M S

Modern high-resolution microscopes, such as the scanning tunneling microscope, are commonly used to study specimens that have dense and aperiodic spatial structure. Extracting meaningful information from images obtained from such…

Computational Physics · Physics 2018-08-28 Sky C. Cheung , John Y. Shin , Yenson Lau , Zhengyu Chen , Ju Sun , Yuqian Zhang , John N. Wright , Abhay N. Pasupathy

Predicting genetic mutations from whole slide images is indispensable for cancer diagnosis. However, existing work training multiple binary classification models faces two challenges: (a) Training multiple binary classifiers is inefficient…

Computer Vision and Pattern Recognition · Computer Science 2024-06-06 Gexin Huang , Chenfei Wu , Mingjie Li , Xiaojun Chang , Ling Chen , Ying Sun , Shen Zhao , Xiaodan Liang , Liang Lin

We propose TabTransformer, a novel deep tabular data modeling architecture for supervised and semi-supervised learning. The TabTransformer is built upon self-attention based Transformers. The Transformer layers transform the embeddings of…

Machine Learning · Computer Science 2020-12-15 Xin Huang , Ashish Khetan , Milan Cvitkovic , Zohar Karnin

Deepfakes utilise Artificial Intelligence (AI) techniques to create synthetic media where the likeness of one person is replaced with another. There are growing concerns that deepfakes can be maliciously used to create misleading and…

Computer Vision and Pattern Recognition · Computer Science 2022-06-02 Nyee Thoang Lim , Meng Yi Kuan , Muxin Pu , Mei Kuan Lim , Chun Yong Chong

Preliminary diagnosis of fungal infections can rely on microscopic examination. However, in many cases, it does not allow unambiguous identification of the species by microbiologist due to their visual similarity. Therefore, it is usually…

Computer Vision and Pattern Recognition · Computer Science 2020-09-09 Bartosz Zieliński , Agnieszka Sroka-Oleksiak , Dawid Rymarczyk , Adam Piekarczyk , Monika Brzychczy-Włoch

Identifying and selecting high-quality Metamorphic Relations (MRs) is a challenge in Metamorphic Testing (MT). While some techniques for automatically selecting MRs have been proposed, they are either domain-specific or rely on strict…

Software Engineering · Computer Science 2024-01-05 Alejandra Duque-Torres , Dietmar Pfahl , Claus Klammer , Stefan Fischer

Bacteriophages are promising alternative antimicrobial agents due to their high specificity for host bacteria and minimal immunogenicity in humans. However, their therapeutic application is limited by their nature as biological entities,…

Quantitative Methods · Quantitative Biology 2024-12-30 Hyunjin Shim

Background: Significance analysis plays a major role in identifying and ranking genes, transcription factor binding sites, DNA methylation regions, and other high-throughput features for association with disease. We propose a new approach,…

Methodology · Statistics 2017-01-10 Andrew E. Jaffe , John D. Storey , Hongkai Ji , Jeffrey T. Leek

Metagenomics has lowered the barrier to microbial discovery--enabling the identification of novel microbes without isolation--but cultures remain imperative for the deep study of microbes. Cultivation and isolation of non-model microbes…

Molecular Networks · Quantitative Biology 2026-02-26 Olivia Bulka , Chabname Ghassemi Nedjad , Loïc Paulevé , Sylvain Prigent , Clémence Frioux

DNA methylation is an important epigenetic mark that has been studied extensively for its regulatory role in biological processes and diseases. WGBS allows for genome-wide measurements of DNA methylation up to single-base resolutions, yet…

Many fault diagnosis methods of rotating machines are based on discriminative features extracted from signals collected from the key components such as bearings. However, under complex operating conditions, periodic impulsive…

Signal Processing · Electrical Eng. & Systems 2025-12-12 Yuhan Yuan , Xiaomo Jiang , Haibin Yang , Haixin Zhao , Shengbo Wang , Xueyu Cheng , Jigang Meng , Shuhua Yang

Most recent speaker verification systems are based on extracting speaker embeddings using a deep neural network. The pooling layer in the network aims to aggregate frame-level features extracted by the backbone. In this paper, we propose a…

Audio and Speech Processing · Electrical Eng. & Systems 2021-10-12 Yufeng Ma , Yiwei Ding , Miao Zhao , Yu Zheng , Min Liu , Minqiang Xu

As more and more internet users post images online to express their daily emotions, image sentiment analysis has attracted increasing attention. Recently, researchers generally tend to design different neural networks to extract visual…

Computer Vision and Pattern Recognition · Computer Science 2025-02-24 Bin Feng , Shulan Ruan , Mingzheng Yang , Dongxuan Han , Huijie Liu , Kai Zhang , Qi Liu

Vision transformers are nowadays the de-facto choice for image classification tasks. There are two broad categories of classification tasks, fine-grained and coarse-grained. In fine-grained classification, the necessity is to discover…

Computer Vision and Pattern Recognition · Computer Science 2022-08-31 Mohit Vaishnav , Thomas Fel , Ivań Felipe Rodríguez , Thomas Serre

Dynamical systems are found in innumerable forms across the physical and biological sciences, yet all these systems fall naturally into universal equivalence classes: conservative or dissipative, stable or unstable, compressible or…

Machine Learning · Computer Science 2023-02-28 Matthew Ricci , Noa Moriel , Zoe Piran , Mor Nitzan

Obtaining effective representations of DNA sequences is crucial for genome analysis. Metagenomic binning, for instance, relies on genome representations to cluster complex mixtures of DNA fragments from biological samples with the aim of…

Machine Learning · Computer Science 2024-11-05 Abdulkadir Celikkanat , Andres R. Masegosa , Thomas D. Nielsen

Multi-task learning has proven to be effective in improving the performance of correlated tasks. Most of the existing methods use a backbone to extract initial features with independent branches for each task, and the exchange of…

Computer Vision and Pattern Recognition · Computer Science 2023-05-05 Diogo Nunes Goncalves , Jose Marcato Junior , Pedro Zamboni , Hemerson Pistori , Jonathan Li , Keiller Nogueira , Wesley Nunes Goncalves