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Electrocardiogram~(ECG), a key bioelectrical time-series signal, is crucial for assessing cardiac health and diagnosing various diseases. Given its time-series format, ECG data is often incorporated into pre-training datasets for…

Signal Processing · Electrical Eng. & Systems 2026-02-26 Zhijiang Tang , Jiaxin Qi , Yuhua Zheng , Jianqiang Huang

A cardiac digital twin is a virtual replica of a patient-specific heart, mimicking its anatomy and physiology. A crucial step of building a cardiac digital twin is anatomical twinning, where the computational mesh of the digital twin is…

Computational models lie at the intersection of basic neuroscience and healthcare applications because they allow researchers to test hypotheses \textit{in silico} and predict the outcome of experiments and interactions that are very hard…

Neurons and Cognition · Quantitative Biology 2020-09-18 Katharina Glomb , Joana Cabral , Anna Cattani , Alberto Mazzoni , Ashish Raj , Benedetta Franceschiello

We propose a mathematical and numerical model for the simulation of the heart function that couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and includes reduced models for cardiac valves and the circulatory…

Numerical Analysis · Mathematics 2022-08-12 Michele Bucelli , Alberto Zingaro , Pasquale Claudio Africa , Ivan Fumagalli , Luca Dede' , Alfio Quarteroni

Electrocardiographic imaging (ECGI) seeks to reconstruct cardiac electrical activity from body-surface potentials noninvasively. However, the associated inverse problem is severely ill-posed and requires robust regularization. While…

Numerical Analysis · Mathematics 2026-02-16 Manuel Haas , Thomas Grandits , Thomas Pinetz , Thomas Beiert , Simone Pezzuto , Alexander Effland

The electrocardiogram (ECG) is a well-known technique used to diagnose cardiac diseases. To acquire the spatial signal characteristics from the thorax, multiple electrodes are commonly used. Displacements of electrodes affect the signal…

Medical Physics · Physics 2021-12-15 Andra Oltmann , Roman Kusche , Philipp Rostalski

The study of pathological cardiac conditions such as arrhythmias, a major cause of mortality in heart failure, is becoming increasingly informed by computational simulation, numerically modelling the governing equations. This can provide…

Computational Engineering, Finance, and Science · Computer Science 2014-06-09 Nathan Kirk , Alan Benson , Christopher Goodyer , Matthew Hubbard

Simultaneous electrocardiography (ECG) and phonocardiogram (PCG) provide a comprehensive, multimodal perspective on cardiac function by capturing the heart's electrical and mechanical activities, respectively. However, the distinct and…

Machine Learning · Computer Science 2025-06-13 Sajjad Karimi , Amit J. Shah , Gari D. Clifford , Reza Sameni

The inverse problem of electrical impedance tomography is severely ill-posed, meaning that, only limited information about the conductivity can in practice be recovered from boundary measurements of electric current and voltage. Recently it…

Analysis of PDEs · Mathematics 2018-09-20 Henrik Garde , Stratos Staboulis

We consider the problem of computing the satisfaction probability of a formula for stochastic models with parametric uncertainty. We show that this satisfaction probability is a smooth function of the model parameters. This enables us to…

Logic in Computer Science · Computer Science 2014-10-23 Luca Bortolussi , Dimitrios Milios , Guido Sanguinetti

Accurate three-dimensional (3D) reconstruction of cardiac chamber motion from time-resolved medical imaging modalities is of growing interest in both the clinical and biomechanical fields. Despite recent advancement, the cardiac motion…

Medical Physics · Physics 2025-04-18 Francesco Capuano , Yue-Hin Loke , Ibrahim Yildiran , Laura Olivieri , Elias Balaras

Electrocardiogram (ECG) analysis plays a vital role in the early detection, monitoring, and management of various cardiovascular conditions. While existing models have achieved notable success in ECG interpretation, they fail to leverage…

Machine Learning · Computer Science 2026-03-05 Yuhao Xu , Xiaoda Wang , Jiaying Lu , Sirui Ding , Defu Cao , Huaxiu Yao , Yan Liu , Xiao Hu , Carl Yang

We provide a rather simple proof of a homogenization result for the bidomain model of cardiac electrophysiology. Departing from a microscopic cellular model, we apply the theory of two-scale convergence to derive the bidomain model. To…

Analysis of PDEs · Mathematics 2018-11-20 Erik Grandelius , Kenneth H. Karlsen

Developing new methods for predicting electromagnetic instabilities in cardiac activity is of primary importance. However, we still need a comprehensive view of the heart's magnetic activity at the tissue scale. To fill this gap, we present…

An electrocardiogram (EKG) is a common, non-invasive test that measures the electrical activity of a patient's heart. EKGs contain useful diagnostic information about patient health that may be absent from other electronic health record…

Machine Learning · Statistics 2018-12-04 Andrew C. Miller , Ziad Obermeyer , David M. Blei , John P. Cunningham , Sendhil Mullainathan

The diagnostic value of electrocardiogram (ECG) lies in its dynamic characteristics, ranging from rhythm fluctuations to subtle waveform deformations that evolve across time and frequency domains. However, supervised ECG models tend to…

Signal Processing · Electrical Eng. & Systems 2025-07-29 He-Yang Xu , Hongxiang Gao , Yuwen Li , Xiu-Shen Wei , Chengyu Liu

Cardiac digital twins (CDTs) of human cardiac electrophysiology (EP) are digital replicas of patient hearts that match like-for-like clinical observations. The electrocardiogram (ECG), as the most prevalent non-invasive observation of…

Medical Physics · Physics 2024-07-26 Elena Zappon , Matthias A. F. Gsell , Karli Gillette , Gernot Plank

While ventricular electromechanics is extensively studied, four-chamber heart models have only been addressed recently; most of these works however neglect atrial contraction. Indeed, as atria are characterized by a complex physiology…

Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering,…

We present a novel mathematical model that simulates myocardial blood perfusion by embedding multiscale and multiphysics features. Our model incorporates cardiac electrophysiology, active and passive mechanics, hemodynamics, reduced valve…

Computational Engineering, Finance, and Science · Computer Science 2023-03-27 Alberto Zingaro , Christian Vergara , Luca Dede' , Francesco Regazzoni , Alfio Quarteroni