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Recently, the use of $\mathrm{H}_2^+$ ions instead of protons to overcome space charge challenges in compact cyclotrons has received much attention. This technique has the potential to increase the available beam current from compact…

Accelerator Physics · Physics 2022-01-05 Daniel Winklehner , Janet M. Conrad , Joseph Smolsky , Loyd Waites

We are developing a high-current cyclotron as a driver for the IsoDAR neutrino experiment. It accelerates 5 mA H2+ to 60 MeV/amu, after which the electron is removed to produce a 10 mA, 60 MeV proton beam. The enabling innovations that…

Accelerator Physics · Physics 2024-04-30 D. Winklehner , J. R. Alonso , J. M. Conrad

Synchrotron radiation has been used for many years as a beam diagnostic at electron accelerators. It is not normally associated with proton accelerators as the intensity of the radiation is too weak to make detection practical. However, if…

Instrumentation and Detectors · Physics 2011-10-17 R. Thurman-Keup , H. W. K. Cheung , A. Hahn , P. Hurh , E. Lorman , C. Lundberg , T. Meyer , D. Miller , S. Pordes , A. Valishev

The Indiana University Cyclotron Facility (IUCF) is in the process of building the Midwest Proton Radiation Institute (MPRI). This involves refurbishing the 200MeV cyclotron and building new facilities for the purpose of providing clinical…

Accelerator Physics · Physics 2007-05-23 J. C. Collins , M. Ball , B. Broderick , J. Katuin , Wm. Manwaring , N. Schreuder

Intensity-modulated proton therapy (IMPT) employs proton radiation rather than conventional X-rays to treat cancerous tumors. This approach offers significant advantages by minimizing the radiation exposure of surrounding healthy tissue,…

Technetium-99m ($^{99m}$Tc) is essential to more than 16 million diagnostic procedures performed annually in the United States. It is typically acquired on-site from generators containing $^{99}$Mo, in turn produced at nuclear reactor…

Accelerator Physics · Physics 2026-03-05 Jarrett Moon , Daniel Winklehner , Jose Alonso , Claire Huchthausen , David McClain , Janet Conrad

A high-voltage divider with accuracy at the ppm level and collinear laser spectroscopy were used to calibrate the highvoltage installation at the radioactive ion beam facility ISOLDE at CERN. The accurate knowledge of this voltage is…

Intensity modulated proton therapy (IMPT) is an advanced cancer treatment modality that offers significant advantages over conventional X-ray therapies, particularly in its ability to minimize radiation dose beyond the tumor target. This…

Medical Physics · Physics 2025-08-06 Hunter D. Ellis , Imteaz Rahaman , Apostoli Hillas , Botong Li , Vikren Sarkar , Kai Fu

We present a practical method to measure the energy of proton beams at a medical cyclotron using the stacked foil technique in combination with a Bayesian inference method. By measuring the $^{48}$V activity induced in a stack of irradiated…

The cyclotron designed for the IsoDAR neutrino source represents a paradigm shift in cyclotron performance -- a factor of 10 increase in beam current. This performance is required to develop a neutrino source of sufficient strength for…

High Energy Physics - Experiment · Physics 2022-03-16 Jose Alonso

Hadron therapy, because of the dosimetric and radiobiological advantages, is more and more often used in tumour treatment. This treatment method leads also to the radioactive effects induced by energetic protons on nuclei. Nuclear reactions…

Medical Physics · Physics 2018-04-26 Przemysław Sękowski , Izabela Skwira-Chalot , Tomasz Matulewicz

Materials to be deployed in space applications have to undergo a variety of different test scenarios, simulating actual space conditions. Among these materials solar photovoltaic cells, optics, meta-materials and more will be directly…

Synchrotron radiation with the characteristic of high brilliance, high level of polarization, high collimation, low emittance and wide tunability in energy has been used as a standard source in metrology(1, 2). For a decade, lots of…

Instrumentation and Detectors · Physics 2019-08-17 LI Hua-Peng , Kun Tang , Yi-Dong Zhao , Lei Zheng , Shu-Hu Liu , Xiao-Liang Zhao , Ya-Shuai Zhao

A system for online measurement of the transverse beam emittance was developed. It is named $^{4}$PrOB$\varepsilon$aM (4-Profiler Online Beam Emittance Measurement) and was conceived to measure the emittance in a fast and efficient way…

Accelerator Physics · Physics 2018-03-22 K. P. Nesteruk , M. Auger , S. Braccini , T. S. Carzaniga , A. Ereditato , P. Scampoli

The very-high current cyclotrons being designed for the IsoDAR and DAEdALUS experiments are of value to fields outside of neutrino physics. In particular, the medical isotopes industry can benefit from these cyclotron developments to…

Nuclear Experiment · Physics 2012-09-25 Jose R. Alonso

Intense laser-driven proton pulses, inherently broadband and highly divergent, pose a challenge to established beamline concepts on the path to application-adapted irradiation field formation, particularly for 3D. Here we experimentally…

MEDICYC (MEDical CYClotron) is an isochronous cyclotron dedicated to radiotherapy which was built and commissioned in Nice, France, in 1990 by a local team aided by experts from CERN. The cyclotron accelerates negative H to a maximum energy…

Accelerator Physics · Physics 2024-09-27 Petter Hofverberg , Jean-Marc Bergerot , Jean-Michel Bruneau , Richard Trimaud

A dedicated clinical synchrotron facility for cancer therapy using energetic proton and ion beams (C, He and O) has been designed at GSI for the Radiologische Universitaetsklinik at Heidelberg, Germany. The design of the injector linac is…

Accelerator Physics · Physics 2007-05-23 B. Schlitt , A. Bechtold , U. Ratzinger , A. Schempp

Purpose: The purpose of this work was to provide a flexible platform for FLASH research with protons by adapting a former clinical pencil beam scanning gantry to irradiations with ultrahigh dose rates. Methods: PSI Gantry 1 treated patients…

The concept of large-radius multistage coaxial cyclotrons having separated orbits is described, to generate proton beams of 120-2000 MeV energy at tens of GW pulsed and hundreds of MW in continuous beam power operation. Accelerated beam…

Accelerator Physics · Physics 2007-05-23 A. R. Tumanyan , N. Z. Akopov , Z. G. Guiragossian , Z. N. Akopov