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Spatial transcriptomics studies are becoming increasingly large and commonplace, necessitating simultaneous analysis of a large number of spatially resolved variables. Correspondingly, a diverse range of methodologies have been proposed to…

Quantitative Methods · Quantitative Biology 2025-09-09 James Boyle , Gregory Hamm , Eleanor Williams , Robin JG Hartman , Magnus Soderburg , Ian Henry , Michael Casey

Persistent homology (PH) encodes global information, such as cycles, and is thus increasingly integrated into graph neural networks (GNNs). PH methods in GNNs typically traverse an increasing sequence of subgraphs. In this work, we first…

Machine Learning · Computer Science 2026-05-15 Mattie Ji , Indradyumna Roy , Vikas Garg

Persistent homology is an important methodology in topological data analysis which adapts theory from algebraic topology to data settings. Computing persistent homology produces persistence diagrams, which have been successfully used in…

Machine Learning · Statistics 2026-01-13 Yueqi Cao , Anthea Monod

In this paper we introduce a statistic, the persistent homology transform (PHT), to model surfaces in $\mathbb{R}^3$ and shapes in $\mathbb{R}^2$. This statistic is a collection of persistence diagrams - multiscale topological summaries…

Statistics Theory · Mathematics 2014-07-16 Katharine Turner , Sayan Mukherjee , Doug M Boyer

Persistent homology is a cornerstone of topological data analysis, offering a multiscale summary of topology with robustness to nuisance transformations, such as rotations and small deformations. Persistent homology has seen broad use…

Methodology · Statistics 2025-11-19 Zitian Wu , Arkaprava Roy , Leo L. Duan

Persistent homology (PH) has recently emerged as a powerful tool for extracting topological features. Integrating PH into machine learning and deep learning models enhances topology awareness and interpretability. However, most PH methods…

Machine Learning · Computer Science 2026-01-05 Xinyang Chen , Amaël Broustet , Guanyuan Zeng , Cheng He , Guoting Chen

Topological data analysis involves the statistical characterization of the shape of data. Persistent homology is a primary tool of topological data analysis, which can be used to analyze topological features and perform statistical…

Methodology · Statistics 2023-03-01 Chul Moon , Nicole A. Lazar

We introduce PH-STAT, a comprehensive MATLAB toolbox designed for performing a wide range of statistical inferences and machine learning tasks on persistent homology, primarily for network and graph data, with an emphasis on brain network…

Algebraic Topology · Mathematics 2025-02-20 Moo K. Chung

The inner representation of deep neural networks (DNNs) is indecipherable, which makes it difficult to tune DNN models, control their training process, and interpret their outputs. In this paper, we propose a novel approach to investigate…

Machine Learning · Computer Science 2021-06-08 Satoru Watanabe , Hayato Yamana

Persistent homology (PH) characterizes the shape of brain networks through persistence features. Group comparison of persistence features from brain networks can be challenging as they are inherently heterogeneous. A recent scale-space…

Persistent homology is a widely-used tool in topological data analysis (TDA) for understanding the underlying shape of complex data. By constructing a filtration of simplicial complexes from data points, it captures topological features…

Algebraic Topology · Mathematics 2025-10-23 Aleksei Luchinsky , Umar Islambekov

The machine learning technique of persistent homology classifies complex systems or datasets by computing their topological features over a range of characteristic scales. There is growing interest in applying persistent homology to…

Optics · Physics 2021-03-03 Daniel Leykam , Dimitris G Angelakis

Persistent homology is a popular technique in topological data analysis that tracks the lifespans of homological features in a nested sequence of spaces. This data is typically presented in a multi-set called a persistence diagram or a…

Algebraic Topology · Mathematics 2025-11-26 Deni Salja

This paper introduces persistent homology, which is a powerful tool to characterize the shape of data using the mathematical concept of topology. We explain the fundamental idea of persistent homology from scratch using some examples. We…

Algebraic Topology · Mathematics 2022-05-25 Ippei Obayashi , Takenobu Nakamura , Yasuaki Hiraoka

Mathematical morphology (MM) is a powerful and widely used framework in image processing. Through set-theoretic and discrete geometric principles, MM operations such as erosion, dilation, opening, and closing effectively manipulate digital…

Software Engineering · Computer Science 2026-02-18 Chuan-Shen Hu

Topological data analysis (TDA) is gaining prominence across a wide spectrum of machine learning tasks that spans from manifold learning to graph classification. A pivotal technique within TDA is persistent homology (PH), which furnishes an…

Recent years have witnessed a fast growth in mathematical artificial intelligence (AI). One of the most successful mathematical AI approaches is topological data analysis (TDA) via persistent homology (PH) that provides explainable AI (xAI)…

General Topology · Mathematics 2025-10-27 Yiming Ren , Guowei Wei

Persistent homology (PH) is a relatively new field in applied mathematics that studies the components and shapes of discrete data. In this work, we demonstrate that PH can be used as a universal framework to identify phases in spin models,…

Statistical Mechanics · Physics 2020-12-11 Bart Olsthoorn , Johan Hellsvik , Alexander V. Balatsky

Topological Data Analysis (TDA) is a novel statistical technique, particularly powerful for the analysis of large and high dimensional data sets. Much of TDA is based on the tool of persistent homology, represented visually via persistence…

Applications · Statistics 2017-11-07 Sarit Agami , Robert J. Adler

Spatial transcriptomics (ST) measures gene expression at a set of spatial locations in a tissue. Communities of nearby cells that express similar genes form \textit{spatial domains}. Specialized ST clustering algorithms have been developed…

Quantitative Methods · Quantitative Biology 2025-11-12 Perry Beamer , Zixuan Cang