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Proteins, essential to biological systems, perform functions intricately linked to their three-dimensional structures. Understanding the relationship between protein structures and their amino acid sequences remains a core challenge in…

Quantitative Methods · Quantitative Biology 2024-11-04 Liang He , Peiran Jin , Yaosen Min , Shufang Xie , Lijun Wu , Tao Qin , Xiaozhuan Liang , Kaiyuan Gao , Yuliang Jiang , Tie-Yan Liu

Source code representations are key in applying machine learning techniques for processing and analyzing programs. A popular approach in representing source code is neural source code embeddings that represents programs with…

Machine Learning · Computer Science 2022-06-17 Md Rafiqul Islam Rabin , Arjun Mukherjee , Omprakash Gnawali , Mohammad Amin Alipour

Word embeddings are often used in natural language processing as a means to quantify relationships between words. More generally, these same word embedding techniques can be used to quantify relationships between features. In this paper, we…

Cryptography and Security · Computer Science 2021-03-11 Aniket Chandak , Wendy Lee , Mark Stamp

A molecular and cellular understanding of how SARS-CoV-2 variably infects and causes severe COVID-19 remains a bottleneck in developing interventions to end the pandemic. We sought to use deep learning to study the biology of SARS-CoV-2…

Machine Learning · Computer Science 2020-12-16 Arijit Sehanobish , Neal G. Ravindra , David van Dijk

The widespread of Coronavirus has led to a worldwide pandemic with a high mortality rate. Currently, the knowledge accumulated from different studies about this virus is very limited. Leveraging a wide-range of biological knowledge, such as…

Molecular Networks · Quantitative Biology 2021-03-09 Junheng Hao , Chelsea Ju , Muhao Chen , Yizhou Sun , Carlo Zaniolo , Wei Wang

The new type of coronavirus disease (COVID-19), which started in Wuhan, China in December 2019, continues to spread rapidly affecting the whole world. It is essential to have a highly sensitive diagnostic screening tool to detect the…

Image and Video Processing · Electrical Eng. & Systems 2020-12-25 Coşku Öksüz , Oğuzhan Urhan , Mehmet Kemal Güllü

Predicting the binding of viral peptides to the major histocompatibility complex with machine learning can potentially extend the computational immunology toolkit for vaccine development, and serve as a key component in the fight against a…

Quantitative Methods · Quantitative Biology 2021-04-19 Johanna Vielhaben , Markus Wenzel , Eva Weicken , Nils Strodthoff

Enveloped viruses enter host cells either through endocytosis, or by direct fusion of the viral membrane envelope and the membrane of the host cell. However, some viruses, such as HIV-1, HSV-1, and Epstein-Barr can enter a cell through…

Subcellular Processes · Quantitative Biology 2009-11-13 Sarah A. Nowak , Tom Chou

Current methods for viral discovery target evolutionarily conserved proteins that accurately identify virus families but remain unable to distinguish the zoonotic potential of newly discovered viruses. Here, we apply an attention-enhanced…

Quantitative Methods · Quantitative Biology 2021-08-19 Kahini Wadhawan , Payel Das , Barbara A. Han , Ilya R. Fischhoff , Adrian C. Castellanos , Arvind Varsani , Kush R. Varshney

Because the infection by Severe Acute Respiratory Syndrome Coronavirus 2 (COVID-19) causes the pneumonia-like effect in the lungs, the examination of chest x-rays can help to diagnose the diseases. For automatic analysis of images, they are…

Image and Video Processing · Electrical Eng. & Systems 2021-06-22 Chiranjibi Sitaula , Sunil Aryal

Coronavirus Disease 2019 (COVID-19) has spread aggressively across the world causing an existential health crisis. Thus, having a system that automatically detects COVID-19 in tomography (CT) images can assist in quantifying the severity of…

Image and Video Processing · Electrical Eng. & Systems 2020-07-08 Issam Laradji , Pau Rodriguez , Oscar Mañas , Keegan Lensink , Marco Law , Lironne Kurzman , William Parker , David Vazquez , Derek Nowrouzezahrai

The issue of COVID-19, increasing with a massive mortality rate. This led to the WHO declaring it as a pandemic. In this situation, it is crucial to perform efficient and fast diagnosis. The reverse transcript polymerase chain reaction…

Computer Vision and Pattern Recognition · Computer Science 2021-08-10 Lalith Bharadwaj B , Rohit Boddeda , Sai Vardhan K , Madhu G

Self-supervised pre-training methods have brought remarkable breakthroughs in the understanding of text, image, and speech. Recent developments in genomics has also adopted these pre-training methods for genome understanding. However, they…

Machine Learning · Computer Science 2022-04-15 Samuel Cahyawijaya , Tiezheng Yu , Zihan Liu , Tiffany T. W. Mak , Xiaopu Zhou , Nancy Y. Ip , Pascale Fung

Coronavirus disease (Covid-19) has been the main agenda of the whole world since it came in sight in December 2019. It has already caused thousands of causalities and infected several millions worldwide. Any technological tool that can be…

Image and Video Processing · Electrical Eng. & Systems 2026-05-06 Mehmet Yamac , Mete Ahishali , Aysen Degerli , Serkan Kiranyaz , Muhammad E. H. Chowdhury , Moncef Gabbouj

The packaging of genetic material within a protein shell, called the capsid, marks a pivotal step in the life cycle of numerous single-stranded RNA viruses. Understanding how hundreds, or even thousands, of proteins assemble around the…

Biological Physics · Physics 2024-09-04 Siyu Li , Guillaume Tresset , Roya Zandi

The rapid and global spread of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), underscored the urgent need for fast, reliable, and adaptable diagnostic tools capable of…

We propose an attention-based method that aggregates local image features to a subject-level representation for predicting disease severity. In contrast to classical deep learning that requires a fixed dimensional input, our method operates…

Computer Vision and Pattern Recognition · Computer Science 2018-07-02 Sumedha Singla , Mingming Gong , Siamak Ravanbakhsh , Frank Sciurba , Barnabas Poczos , Kayhan N. Batmanghelich

Due to SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) being a novel virus, there are currently no known effective antiviral drugs capable of slowing its progress. To accelerate the discovery of potential drug candidates,…

Biomolecules · Quantitative Biology 2020-09-29 Lokesh Agrawal , Thanasis Poullikkas , Scott Eisenhower , Carlo Monsanto , Ranjith Kumar Bakku

The massive amount of genomic data appearing for SARS-CoV-2 since the beginning of the COVID-19 pandemic has challenged traditional methods for studying its dynamics. As a result, new methods such as Pangolin, which can scale to the…

Quantitative Methods · Quantitative Biology 2022-11-16 Prakash Chourasia , Sarwan Ali , Simone Ciccolella , Gianluca Della Vedova , Murray Patterson

Respiratory symptoms can be a caused by different underlying conditions, and are often caused by viral infections, such as Influenza-like illnesses or other emerging viruses like the Coronavirus. These respiratory viruses, often, have…

Signal Processing · Electrical Eng. & Systems 2020-07-02 Abdelkader Nasreddine Belkacem , Sofia Ouhbi , Abderrahmane Lakas , Elhadj Benkhelifa , Chao Chen
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