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Conventional nuclear magnetic resonance (NMR) spectroscopy relies on acquiring signal from a macroscopic ensemble of molecules to gain information about molecular structure and dynamics. Transferring this technique to nanoscale sample sizes…

Mesoscale and Nanoscale Physics · Physics 2019-02-06 Jeffrey Holzgrafe , Qiushi Gu , Jan Beitner , Dhiren Kara , Helena S. Knowles , Mete Atatüre

Nitrogen-vacancy (NV) quantum defects in diamond are sensitive detectors of magnetic fields. Due to their atomic size and optical readout capability, they have been used for magnetic resonance spectroscopy of nanoscale samples on diamond…

Nitrogen vacancy (NV) centers in diamond have been used as ultrasensitive magnetometers to perform nuclear magnetic resonance (NMR) spectroscopy of statistically polarized samples at 1 - 100 nm length scales. However, the spectral linewidth…

Nanomagnetometry using the nitrogen-vacancy (NV) centre in diamond has attracted a great deal of interest because of the combined features of room temperature operation, nanoscale resolution and high sensitivity. One of the important goals…

Two-dimensional Nuclear Magnetic Resonance (NMR) is essential in molecular structure determination. The Nitrogen-Vacancy (NV) center in diamond has been proposed and developed as an outstanding quantum sensor to realize NMR in nanoscale. In…

Nuclear magnetic resonance (NMR) spectroscopy provides unparalleled access to molecular structure and dynamics but is traditionally limited by weak signal strength, requiring large sample volumes and high magnetic fields. Here, we…

Applied Physics · Physics 2026-04-29 Dileep Singh , Riley W. Hooper , Christoph Findler , Utsab Banerjee , Dominik B. Bucher

Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are well-established techniques that provide valuable information in a diverse set of disciplines but are currently limited to macroscopic sample volumes. Here we…

We demonstrate nuclear magnetic resonance (NMR) spectroscopy of picoliter-volume solutions with a nanostructured diamond chip. Using optical interferometric lithography, diamond surfaces were nanostructured with dense, high-aspect-ratio…

Mesoscale and Nanoscale Physics · Physics 2017-11-01 P. Kehayias , A. Jarmola , N. Mosavian , I. Fescenko , F. M. Benito , A. Laraoui , J. Smits , L. Bougas , D. Budker , A. Neumann , S. R. J. Brueck , V. M. Acosta

The nitrogen-vacancy (NV) center in diamond has enabled studies of nanoscale nuclear magnetic resonance (NMR) and electron paramagnetic resonance with high sensitivity in small sample volumes. Most NV-detected NMR (NV-NMR) experiments are…

Mesoscale and Nanoscale Physics · Physics 2023-07-27 Yuhang Ren , Cooper Selco , Dylan Kawashiri , Michael Coumans , Benjamin Fortman , Louis S. Bouchard , Karoly Holczer , Susumu Takahashi

We present nanoscale NMR measurements performed with nitrogen-vacancy (NV) centers located down to about 2 nm from the diamond surface. NV centers were created by shallow ion implantation followed by a slow, nanometer-by-nanometer removal…

Mesoscale and Nanoscale Physics · Physics 2014-01-24 M. Loretz , S. Pezzagna , J. Meijer , C. L. Degen

Optically-probed nitrogen-vacancy (NV) quantum defects in diamond can detect nuclear magnetic resonance (NMR) signals with high-spectral resolution from micron-scale sample volumes of about 10 picoliters. However, a key challenge for NV-NMR…

Nuclear magnetic resonance (NMR) spectroscopy has approached the limit of single molecule sensitivity, however the spectral resolution is currently insufficient to obtain detailed information on chemical structure and molecular…

Quantum Physics · Physics 2015-08-19 Xi Kong , Alexander Stark , Jiangfeng Du , Liam P. McGuinness , Fedor Jelezko

The implementation of nuclear magnetic resonance (NMR) at the nanoscale is a major challenge, as conventional systems require relatively large ensembles of spins and limit resolution to mesoscopic scales. New approaches based on quantum…

Optically active quantum defects in solids, such as the nitrogen vacancy (NV) center in diamond, are a leading modality for micron-scale and nanoscale (ultralow-mass) nuclear magnetic resonance (NMR) spectroscopy and imaging under ambient…

Characterization of the molecular properties of surfaces under ambient or chemically reactive conditions is a fundamental scientific challenge. Moreover, many traditional analytical techniques used for probing surfaces often lack dynamic or…

Nitrogen-vacancy (NV) centers in diamond have emerged as quantum sensors capable of detecting nuclear magnetic resonance (NMR) signals at unprecedented length scales, ranging from picoliter sample volumes down to single spins at the diamond…

Chemical Physics · Physics 2025-01-07 Nick R. von Grafenstein , Karl D. Briegel , Jorge Casanova , Dominik B. Bucher

Nuclear magnetic resonance (NMR) spectroscopy is a widely used tool for chemical analysis and molecular structure identification. Because it typically relies on the weak magnetic fields produced by a small thermal nuclear spin polarization,…

Applied Physics · Physics 2020-06-11 Dominik B. Bucher , David R. Glenn , Hongkun Park , Mikhail D. Lukin , Ronald L. Walsworth

We demonstrate a robust experimental method for determining the depth of individual shallow Nitrogen-Vacancy (NV) centers in diamond with $\sim1$ nm uncertainty. We use a confocal microscope to observe single NV centers and detect the…

Atomic-scale magnetic field sensors based on nitrogen vacancy (NV) defects in diamonds are an exciting platform for nanoscale nuclear magnetic resonance (NMR) spectroscopy. The detection of NMR signals from a few zeptoliters to single…

The integration of NMR and high pressure technique brings unique opportunities to study electronic, structural and dynamical properties under extreme conditions. Despite a great degree of success has been achieved using coil-based schemes,…

Quantum Physics · Physics 2022-03-22 Yan-Xing Shang , Fang Hong , Jian-Hong Dai , Ya-Nan Lu , Hui Yu , Yong-Hong Yu , Xiao-Hui Yu , Xin-Yu Pan , Gang-Qin Liu
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