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Full scale simulations of neuronal network models of the brain are challenging due to the high density of connections between neurons. This contribution reports run times shorter than the simulated span of biological time for a full scale…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-10-04 Anno C. Kurth , Johanna Senk , Dennis Terhorst , Justin Finnerty , Markus Diesmann

We propose a neural network model of multi-neuron interacting system that simulates neurons to interact each other through the surroundings of neuronal cell bodies. We physically model the neuronal cell surroundings, include the dendrites,…

Neurons and Cognition · Quantitative Biology 2021-07-05 Yu-Juan Sun , Wei-Min Zhang

Living neuronal networks in dissociated neuronal cultures are widely known for their ability to generate highly robust spatiotemporal activity patterns in various experimental conditions. These include neuronal avalanches satisfying the…

Adaptation and Self-Organizing Systems · Physics 2022-05-17 I. Y. Tyukin , D. Iudin , F. Iudin , T. Tyukina , V. Kazantsev , I. Mukhina , A. N. Gorban

For three decades statistical mechanics has been providing a framework to analyse neural networks. However, the theoretically tractable models, e.g., perceptrons, random features models and kernel machines, or multi-index models and…

Machine Learning · Statistics 2025-06-02 Jean Barbier , Francesco Camilli , Minh-Toan Nguyen , Mauro Pastore , Rudy Skerk

An important part of the analysis of bio-molecular networks is to detect different functional units. Different functions are reflected in a different evolutionary dynamics, and hence in different statistical characteristics of network…

Molecular Networks · Quantitative Biology 2007-05-23 Johannes Berg , Michael Lässig

A fundamental premise of statistical physics is that the particles in a physical system are interchangeable, and hence the state of each specific component is representative of the system as a whole. This assumption breaks down for complex…

Physics and Society · Physics 2025-12-16 Neil G. MacLaren , Baruch Barzel , Naoki Masuda

Neural systems can be modeled as networks of functionally connected neural elements. The resulting network can be analyzed using mathematical tools from network science and graph theory to quantify the system's topological organization and…

Neurons and Cognition · Quantitative Biology 2020-07-01 Richard F. Betzel , Katherine C. Wood , Christopher Angeloni , Maria Neimark Geffen , Danielle S. Bassett

We explore the interplay between the topological relevance of a neuron and its dynamical traces in experimental cultured neuronal networks. We monitor the growth and development of these networks to characterise the evolution of their…

Adaptation and Self-Organizing Systems · Physics 2023-07-14 A. Tlaie , L. M. Ballesteros-Esteban , I. Leyva , I. Sendina-Nadal

Most nervous systems encode information about stimuli in the responding activity of large neuronal networks. This activity often manifests itself as dynamically coordinated sequences of action potentials. Since multiple electrode recordings…

Neurons and Cognition · Quantitative Biology 2011-11-09 Kristina Lisa Klinkner , Cosma Rohilla Shalizi , Marcelo F. Camperi

Deep learning techniques are increasingly being adopted for classification tasks over the past decade, yet explaining how deep learning architectures can achieve state-of-the-art performance is still an elusive goal. While all the training…

Machine Learning · Computer Science 2021-10-12 Sakib Mostafa , Debajyoti Mondal

The principles of neural encoding and computations are inherently collective and usually involve large populations of interacting neurons with highly correlated activities. While theories of neural function have long recognized the…

Neurons and Cognition · Quantitative Biology 2019-05-14 Christophe Gardella , Olivier Marre , Thierry Mora

In the last 15 years, statistical physics has been a very successful framework to model complex networks. On the theoretical side, this approach has brought novel insights into a variety of physical phenomena, such as self-organisation,…

Biological phenomena differ significantly from physical phenomena. At the heart of this distinction is the fact that biological entities have computational abilities and thus they are inherently difficult to predict. This is the reason why…

Molecular Networks · Quantitative Biology 2009-09-29 Pau Fernandez , Ricard V. Sole

Activity in neocortex exhibits a range of behaviors, from irregular to temporally precise, and from weakly to strongly correlated. So far there has been no single theoretical framework that could explain all these behaviors, leaving open…

Neurons and Cognition · Quantitative Biology 2015-11-03 Alexander Lerchner , Peter E. Latham

Self-sustained activity in the brain is observed in the absence of external stimuli and contributes to signal propagation, neural coding, and dynamic stability. It also plays an important role in cognitive processes. In this work, by means…

Understanding how the brain learns to compute functions reliably, efficiently and robustly with noisy spiking activity is a fundamental challenge in neuroscience. Most sensory and motor tasks can be described as dynamical systems and could…

Neurons and Cognition · Quantitative Biology 2017-05-24 Sophie Denève , Alireza Alemi , Ralph Bourdoukan

Biological systems, from a cell to the human brain, are inherently complex. A powerful representation of such systems, described by an intricate web of relationships across multiple scales, is provided by complex networks. Recently, several…

Quantitative Methods · Quantitative Biology 2018-02-06 M. De Domenico

We all are fascinated by the phenomena of intelligent behavior, as generated both by our own brains and by the brains of other animals. As physicists we would like to understand if there are some general principles that govern the structure…

Biological Physics · Physics 2007-05-23 William Bialek

Inspired by empirical studies of networked systems such as the Internet, social networks, and biological networks, researchers have in recent years developed a variety of techniques and models to help us understand or predict the behavior…

Statistical Mechanics · Physics 2015-06-24 M. E. J. Newman

Traditional mathematical approaches to studying analytically the dynamics of neural networks rely on the mean-field approximation, which is rigorously applicable only to networks of infinite size. However, all existing real biological…

Neurons and Cognition · Quantitative Biology 2019-04-30 Diego Fasoli , Stefano Panzeri