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A key challenge in program synthesis is the astronomical size of the search space the synthesizer has to explore. In response to this challenge, recent work proposed to guide synthesis using learned probabilistic models. Obtaining such a…

Programming Languages · Computer Science 2020-10-20 Shraddha Barke , Hila Peleg , Nadia Polikarpova

Classifier-free guidance is a key component for enhancing the performance of conditional generative models across diverse tasks. While it has previously demonstrated remarkable improvements for the sample quality, it has only been…

Machine Learning · Computer Science 2023-12-11 Qinqing Zheng , Matt Le , Neta Shaul , Yaron Lipman , Aditya Grover , Ricky T. Q. Chen

Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the…

Biomolecules · Quantitative Biology 2019-04-23 Kevin K. Yang , Zachary Wu , Frances H. Arnold

Algorithms proposed for solving high-dimensional optimization problems with no derivative information frequently encounter the "curse of dimensionality," becoming ineffective as the dimension of the parameter space grows. One feature of a…

Optimization and Control · Mathematics 2020-04-28 Dmitry Pozharskiy , Noah J. Wichrowski , Andrew B. Duncan , Grigorios A. Pavliotis , Ioannis G. Kevrekidis

In this research we propose a new method for training predictive machine learning models for prescriptive applications. This approach, which we refer to as coupled validation, is based on tweaking the validation step in the standard…

Machine Learning · Computer Science 2021-10-25 Ebrahim Mortaz , Alexander Vinel

We present a deep reinforcement learning approach to minimizing the execution cost of neural network computation graphs in an optimizing compiler. Unlike earlier learning-based works that require training the optimizer on the same graph to…

Machine Learning · Computer Science 2020-02-11 Aditya Paliwal , Felix Gimeno , Vinod Nair , Yujia Li , Miles Lubin , Pushmeet Kohli , Oriol Vinyals

It is shown how to use the performance and data profile benchmarking tools to improve algorithms' performance. An illustration for the BFO derivative-free optimizer suggests that the obtained gains are potentially significant.

Optimization and Control · Mathematics 2021-05-31 Margherita Porcelli , Philippe L. Toint

This paper introduces a novel approach to system identification for nonlinear input-output models that minimizes the simulation error and frames the problem as a constrained optimization task. The proposed method addresses vanishing…

Optimization and Control · Mathematics 2025-12-17 Vito Cerone , Sophie M. Fosson , Simone Pirrera , Diego Regruto

Likelihood profiling is an efficient and powerful frequentist approach for parameter estimation, uncertainty quantification and practical identifiablity analysis. Unfortunately, these methods cannot be easily applied for stochastic models…

Code super-optimization is the task of transforming any given program to a more efficient version while preserving its input-output behaviour. In some sense, it is similar to the paraphrase problem from natural language processing where the…

Machine Learning · Computer Science 2017-06-29 Rudy Bunel , Alban Desmaison , M. Pawan Kumar , Philip H. S. Torr , Pushmeet Kohli

This paper presents a novel method for utilizing fine-tuned Large Language Models (LLMs) to minimize data requirements in load profile analysis, demonstrated through the restoration of missing data in power system load profiles. A two-stage…

Machine Learning · Computer Science 2024-06-05 Yi Hu , Hyeonjin Kim , Kai Ye , Ning Lu

Input-sensitive profiling is a recent performance analysis technique that makes it possible to estimate the empirical cost function of individual routines of a program, helping developers understand how performance scales to larger inputs…

Performance · Computer Science 2013-04-16 Emilio Coppa , Camil Demetrescu , Irene Finocchi , Romolo Marotta

With the demand for machine learning increasing, so does the demand for tools which make it easier to use. Automated machine learning (AutoML) tools have been developed to address this need, such as the Tree-Based Pipeline Optimization Tool…

Neural and Evolutionary Computing · Computer Science 2018-03-13 Pieter Gijsbers , Joaquin Vanschoren , Randal S. Olson

Directed evolution is an iterative laboratory process of designing proteins with improved function by iteratively synthesizing new protein variants and evaluating their desired property with expensive and time-consuming biochemical…

Machine Learning · Computer Science 2025-09-08 Matouš Soldát , Jiří Kléma

The design of optimal test statistics is a key task in frequentist statistics and for a number of scenarios optimal test statistics such as the profile-likelihood ratio are known. By turning this argument around we can find the profile…

Methodology · Statistics 2022-03-25 Lukas Heinrich

The prohibitive expense of automatic performance tuning at scale has largely limited the use of autotuning to libraries for shared-memory and GPU architectures. We introduce a framework for approximate autotuning that achieves a desired…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-03-03 Edward Hutter , Edgar Solomonik

Leveraging machine-learning (ML) techniques for compiler optimizations has been widely studied and explored in academia. However, the adoption of ML in general-purpose, industry strength compilers has yet to happen. We propose MLGO, a…

Programming Languages · Computer Science 2021-01-14 Mircea Trofin , Yundi Qian , Eugene Brevdo , Zinan Lin , Krzysztof Choromanski , David Li

Recent advances in large language models (LLMs) have enabled realistic user simulators for developing and evaluating recommender systems (RSs). However, existing LLM-based simulators for RSs face two major limitations: (1) static and…

Information Retrieval · Computer Science 2026-01-21 Hongyang Liu , Zhu Sun , Tianjun Wei , Yan Wang , Jiajie Zhu , Xinghua Qu

Bio-inspired optimization (including Evolutionary Computation and Swarm Intelligence) is a growing research topic with many competitive bio-inspired algorithms being proposed every year. In such an active area, preparing a successful…

Neural and Evolutionary Computing · Computer Science 2024-10-07 Antonio LaTorre , Daniel Molina , Eneko Osaba , Javier Del Ser , Francisco Herrera

We present a non-destructive beam profile imaging concept that utilizes machine learning tools, namely genetic algorithm with a gradient descent-like minimization. Electromagnetic fields around a charged beam carry information about its…

Instrumentation and Detectors · Physics 2021-11-29 Zhanibek Omarov , Selcuk Haciomeroglu
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