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We consider machine learning techniques to develop low-latency approximate solutions to a class of inverse problems. More precisely, we use a probabilistic approach for the problem of recovering sparse stochastic signals that are members of…

Information Theory · Computer Science 2016-09-06 Steffen Limmer , Sławomir Stańczak

In genomics, differential abundance and expression analyses are complicated by the compositional nature of sequence count data, which reflect only relative-not absolute-abundances or expression levels. Many existing methods attempt to…

Methodology · Statistics 2025-12-16 Won Gu , Francesca Chiaromonte , Justin D. Silverman

We address the challenge of performing Targeted Maximum Likelihood Estimation (TMLE) after an initial Highly Adaptive Lasso (HAL) fit. Existing approaches that utilize the data-adaptive working model selected by HAL-such as the relaxed HAL…

Methodology · Statistics 2025-06-23 Yi Li , Sky Qiu , Zeyi Wang , Mark van der Laan

We suggest an iterative approach to computing K-step maximum likelihood estimates (MLE) of the parametric components in semiparametric models based on their profile likelihoods. The higher order convergence rate of K-step MLE mainly depends…

Statistics Theory · Mathematics 2007-08-23 Guang Cheng

We consider a semiparametric mixture of two univariate density functions where one of them is known while the weight and the other function are unknown. Such mixtures have a history of application to the problem of detecting differentially…

Statistics Theory · Mathematics 2017-08-01 Zhou Shen , Michael Levine , Zuofeng Shang

The inherent bias pathology of the maximum likelihood (ML) estimation method is confirmed for models with unknown parameters $\theta$ and $\psi$ when MLE $\hat \psi$ is function of MLE $\hat \theta.$ To reduce $\hat \psi$'s bias the…

Statistics Theory · Mathematics 2014-09-11 Yannis G. Yatracos

The Multi-Reference Alignment (MRA) problem aims at the recovery of an unknown signal from repeated observations under the latent action of a group of cyclic isometries, in the presence of additive noise of high intensity $\sigma$. It is a…

Statistics Theory · Mathematics 2023-12-14 Subhro Ghosh , Soumendu Sundar Mukherjee , Jing Bin Pan

We propose an l1-regularized likelihood method for estimating the inverse covariance matrix in the high-dimensional multivariate normal model in presence of missing data. Our method is based on the assumption that the data are missing at…

Methodology · Statistics 2012-02-28 Nicolas Städler , Peter Bühlmann

The Potts model is frequently used to describe the behavior of image classes, since it allows to incorporate contextual information linking neighboring pixels in a simple way. Its isotropic version has only one real parameter beta, known as…

Applications · Statistics 2014-05-08 J. Gimenez , A. C. Frery , Ana Georgina Flesia

In many social, economical, biological and medical studies, one objective is to classify a subject into one of several classes based on a set of variables observed from the subject. Because the probability distribution of the variables is…

Statistics Theory · Mathematics 2011-05-19 Jun Shao , Yazhen Wang , Xinwei Deng , Sijian Wang

Various studies that address the compressed sensing problem with Multiple Measurement Vectors (MMVs) have been recently carried. These studies assume the vectors of the different channels to be jointly sparse. In this paper, we relax this…

Machine Learning · Computer Science 2016-11-14 Hamid Palangi , Rabab Ward , Li Deng

The two primary approaches for high-dimensional regression problems are sparse methods (e.g., best subset selection, which uses the L0-norm in the penalty) and ensemble methods (e.g., random forests). Although sparse methods typically yield…

Methodology · Statistics 2024-10-31 Anthony-Alexander Christidis , Stefan Van Aelst , Ruben Zamar

We consider a problem of model selection in high-dimensional binary Markov random fields. The usefulness of the Ising model in studying systems of complex interactions has been confirmed in many papers. The main drawback of this model is…

Methodology · Statistics 2018-12-11 Błażej Miasojedow , Wojciech Rejchel

Sparse additive models have attracted much attention in high-dimensional data analysis due to their flexible representation and strong interpretability. However, most existing models are limited to single-level learning under the…

Machine Learning · Computer Science 2026-04-23 Xuelin Zhang , Xinyue Liu , Lingjuan Wu , Hong Chen

Analyzing overdispersed, zero-inflated, longitudinal count data poses significant modeling and computational challenges, which standard count models (e.g., Poisson or negative binomial mixed effects models) fail to adequately address. We…

Methodology · Statistics 2026-02-11 John Barrera , Ana Arribas-Gil , Dae-Jin Lee , Cristian Meza

Multiple systems estimation strategies have recently been applied to quantify hard-to-reach populations, particularly when estimating the number of victims of human trafficking and modern slavery. In such contexts, it is not uncommon to see…

Methodology · Statistics 2020-03-06 Lax Chan , Bernard W. Silverman , Kyle Vincent

We consider a linear regression model with a spatially correlated error term on a lattice. When estimating coefficients in the linear regression model, the generalized least squares estimator (GLSE) is used if the covariance structures are…

Methodology · Statistics 2014-10-07 Toshihiro Hirano

This paper addresses the item ranking problem with associate covariates, focusing on scenarios where the preference scores can not be fully explained by covariates, and the remaining intrinsic scores, are sparse. Specifically, we extend the…

Methodology · Statistics 2024-07-15 Jianqing Fan , Jikai Hou , Mengxin Yu

Shrinkage estimators that possess the ability to produce sparse solutions have become increasingly important to the analysis of today's complex datasets. Examples include the LASSO, the Elastic-Net and their adaptive counterparts.…

Methodology · Statistics 2017-02-09 Hongmei Liu , J. Sunil Rao

We consider the problem of learning a sparse graph underlying an undirected Gaussian graphical model, a key problem in statistical machine learning. Given $n$ samples from a multivariate Gaussian distribution with $p$ variables, the goal is…

Machine Learning · Computer Science 2026-04-07 Kayhan Behdin , Wenyu Chen , Rahul Mazumder
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