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Age is one of the major known risk factors for Alzheimer's Disease (AD). Detecting AD early is crucial for effective treatment and preventing irreversible brain damage. Brain age, a measure derived from brain imaging reflecting structural…

Image and Video Processing · Electrical Eng. & Systems 2024-05-07 Jay Shah , Md Mahfuzur Rahman Siddiquee , Yi Su , Teresa Wu , Baoxin Li

Deep learning algorithms for predicting neuroimaging data have shown considerable promise in various applications. Prior work has demonstrated that deep learning models that take advantage of the data's 3D structure can outperform standard…

Image and Video Processing · Electrical Eng. & Systems 2023-03-07 Yuda Bi , Anees Abrol , Zening Fu , Jiayu Chen , Jingyu Liu , Vince Calhoun

In this work, deep learning techniques for brain age prediction from magnetic resonance images are investigated, aiming to assist in the identification of biomarkers of the natural aging process. The identification of biomarkers is useful…

Image and Video Processing · Electrical Eng. & Systems 2021-12-24 Victor H. R. Oliveira , Augusto Antunes , Alexandre S. Soares , Arthur D. Reys , Robson Z. Júnior , Saulo D. S. Pedro , Danilo Silva

Fetal brain imaging is a cornerstone of prenatal screening and early diagnosis of congenital anomalies. Knowledge of fetal gestational age is the key to the accurate assessment of brain development. This study develops an attention-based…

Computer Vision and Pattern Recognition · Computer Science 2018-12-19 Liyue Shen , Katie Shpanskaya , Edward Lee , Emily McKenna , Maryam Maleki , Quin Lu , Safwan Halabi , John Pauly , Kristen Yeom

Visualizing and interpreting convolutional neural networks (CNNs) is an important task to increase trust in automatic medical decision making systems. In this study, we train a 3D CNN to detect Alzheimer's disease based on structural MRI…

Computer Vision and Pattern Recognition · Computer Science 2018-12-07 Johannes Rieke , Fabian Eitel , Martin Weygandt , John-Dylan Haynes , Kerstin Ritter

Convolutional Neural Network (CNN) has been successfully applied on classification of both natural images and medical images but not yet been applied to differentiating patients with schizophrenia from healthy controls. Given the subtle,…

Computer Vision and Pattern Recognition · Computer Science 2020-03-20 Mengjiao Hu , Kang Sim , Juan Helen Zhou , Xudong Jiang , Cuntai Guan

We propose an interpretable 3D Grid-Attention deep neural network that can accurately predict a person's age and whether they have Alzheimer's disease (AD) from a structural brain MRI scan. Building on a 3D convolutional neural network, we…

Tissues and Organs · Quantitative Biology 2020-11-19 Pradeep Lam , Alyssa H. Zhu , Iyad Ba Gari , Neda Jahanshad , Paul M. Thompson

Brain tumor detection and classification are critical tasks in medical image analysis, particularly in early-stage diagnosis, where accurate and timely detection can significantly improve treatment outcomes. In this study, we apply various…

Computer Vision and Pattern Recognition · Computer Science 2024-11-08 Alice Oh , Inyoung Noh , Jian Choo , Jihoo Lee , Justin Park , Kate Hwang , Sanghyeon Kim , Soo Min Oh

Brain extraction or whole brain segmentation is an important first step in many of the neuroimage analysis pipelines. The accuracy and robustness of brain extraction, therefore, is crucial for the accuracy of the entire brain analysis…

Computer Vision and Pattern Recognition · Computer Science 2017-06-21 Seyed Sadegh Mohseni Salehi , Deniz Erdogmus , Ali Gholipour

Preterm infants (born between 28 and 37 weeks of gestation) face elevated risks of neurodevelopmental delays, making early identification crucial for timely intervention. While deep learning-based volumetric segmentation of brain MRI scans…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Lexin Ren , Jiamiao Lu , Weichuan Zhang , Benqing Wu , Tuo Wang , Yi Liao , Jiapan Guo , Changming Sun , Liang Guo

Deep learning (DL) methods are increasingly outperforming classical approaches in brain imaging, yet their generalizability across diverse imaging cohorts remains inadequately assessed. As age and sex are key neurobiological markers in…

The human brain undergoes rapid development during the third trimester of pregnancy. In this work, we model the neonatal development of the infant brain in this age range. As a basis, we use MR images of preterm- and term-birth neonates…

Image and Video Processing · Electrical Eng. & Systems 2024-08-19 Florentin Bieder , Paul Friedrich , Hélène Corbaz , Alicia Durrer , Julia Wolleb , Philippe C. Cattin

We propose to apply a 2D CNN architecture to 3D MRI image Alzheimer's disease classification. Training a 3D convolutional neural network (CNN) is time-consuming and computationally expensive. We make use of approximate rank pooling to…

Computer Vision and Pattern Recognition · Computer Science 2021-01-14 Xin Xing , Gongbo Liang , Hunter Blanton , Muhammad Usman Rafique , Chris Wang , Ai-Ling Lin , Nathan Jacobs

A three-dimensional convolutional neural network was developed to classify T1-weighted brain MRI scans as healthy or Alzheimer. The network comprises 3D convolution, pooling, batch normalization, dense ReLU layers, and a sigmoid output.…

Image and Video Processing · Electrical Eng. & Systems 2025-06-18 Thien Nhan Vo , Bac Nam Ho

Brain aging is a complex and dynamic process, leading to functional and structural changes in the brain. These changes could lead to the increased risk of neurodegenerative diseases and cognitive decline. Accurate brain-age estimation…

Image and Video Processing · Electrical Eng. & Systems 2024-12-30 Saadat Behzadi , Danial Sharifrazi , Roohallah Alizadehsani , Mojtaba Lotfaliany , Mohammadreza Mohebbi

Over 30 papers have proposed to use convolutional neural network (CNN) for AD classification from anatomical MRI. However, the classification performance is difficult to compare across studies due to variations in components such as…

The deviation between chronological age and biological age is a well-recognized biomarker associated with cognitive decline and neurodegeneration. Age-related and pathology-driven changes to brain structure are captured by various…

Machine Learning · Computer Science 2022-11-01 Saurabh Sihag , Gonzalo Mateos , Corey McMillan , Alejandro Ribeiro

Early detection is a crucial goal in the study of Alzheimer's Disease (AD). In this work, we describe several techniques to boost the performance of 3D deep convolutional neural networks (CNNs) trained to detect AD using structural brain…

Image and Video Processing · Electrical Eng. & Systems 2020-04-07 Sheng Liu , Chhavi Yadav , Carlos Fernandez-Granda , Narges Razavian

Segmentation of magnetic resonance images (MRI) facilitates analysis of human brain development by delineating anatomical structures. However, in infants and young children, accurate segmentation is challenging due to development and…

Machine Learning · Computer Science 2026-04-01 Malte Hoffmann , Lilla Zöllei , Adrian V. Dalca

Longitudinal analysis has great potential to reveal developmental trajectories and monitor disease progression in medical imaging. This process relies on consistent and robust joint 4D segmentation. Traditional techniques are dependent on…

Machine Learning · Computer Science 2019-06-19 Malav Bateriwala , Pierrick Bourgeat