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Identifying and characterizing relationships between treatments, exposures, or other covariates and time-to-event outcomes has great significance in a wide range of biomedical settings. In research areas such as multi-center clinical…

Methodology · Statistics 2025-04-02 Hillary M. Heiling , Naim U. Rashid , Quefeng Li , Xianlu L. Peng , Jen Jen Yeh

We present ASCENDgpt, a transformer-based model specifically designed for cardiovascular risk prediction from longitudinal electronic health records (EHRs). Our approach introduces a novel phenotype-aware tokenization scheme that maps…

Computation and Language · Computer Science 2025-09-08 Chris Sainsbury , Andreas Karwath

Recent advances in using quantitative ultrasound (QUS) methods have provided a promising framework to non-invasively and inexpensively monitor or predict the effectiveness of therapeutic cancer responses. One of the earliest steps in using…

Computer Vision and Pattern Recognition · Computer Science 2017-01-16 Mehrdad J. Gangeh , Hamid R. Tizhoosh , Kan Wu , Dun Huang , Hadi Tadayyon , Gregory J. Czarnota

Objective: To develop an effective and scalable individual-level patient cost prediction method by automatically learning hidden temporal patterns from multivariate time series data in patient insurance claims using a convolutional neural…

Machine Learning · Computer Science 2020-09-16 Mohammad Amin Morid , Olivia R. Liu Sheng , Kensaku Kawamoto , Samir Abdelrahman

The interpretation of the results of survival analysis often benefits from latent factor representations of baseline covariates. However, existing methods, such as Nonnegative Matrix Factorization (NMF), do not incorporate survival…

Machine Learning · Computer Science 2025-08-26 Paul Fogel , Christophe Geissler , George Luta

Treatment of cancer involves heterogeneous, complex care pathways. The relationship between these longitudinal trajectories, baseline mental health, and prognostic outcomes remains poorly understood. We introduce an interpretable…

Lung cancer is among the most common cancers in the United States, in terms of incidence and mortality. In 2009, it is estimated that more than 150,000 deaths will result from lung cancer alone. Genetic information is an extremely valuable…

Applications · Statistics 2011-08-10 Brent A. Johnson , Qi Long

Cancer is a number of related yet highly heterogeneous diseases. Correct identification of cancer subtypes is critical for clinical decisions. The advance in sequencing technologies has made it possible to study cancer based on abundant…

Applications · Statistics 2018-11-27 Xiaochun Chen , Honggang Wang , Donghui Yan

Breast cancer's complexity and variability pose significant challenges in understanding its progression and guiding effective treatment. This study aims to integrate protein sequence data with expression levels to improve the molecular…

Biomolecules · Quantitative Biology 2025-10-31 Hossein Sholehrasa , Majid Jaberi-Douraki

As much as data science is playing a pivotal role everywhere, healthcare also finds it prominent application. Breast Cancer is the top rated type of cancer amongst women; which took away 627,000 lives alone. This high mortality rate due to…

Machine Learning · Computer Science 2019-02-26 Vivek Kumar , Brojo Kishore Mishra , Manuel Mazzara , Dang N. H. Thanh , Abhishek Verma

Risk prediction is central to both clinical medicine and public health. While many machine learning models have been developed to predict mortality, they are rarely applied in the clinical literature, where classification tasks typically…

Machine Learning · Statistics 2017-12-05 Maggie Makar , Marzyeh Ghassemi , David Cutler , Ziad Obermeyer

Purpose: We propose a general framework for quantifying predictive uncertainties of dose-related quantities and leveraging this information in a dose mimicking problem in the context of automated radiation therapy treatment planning.…

Medical Physics · Physics 2021-09-08 Tianfang Zhang , Rasmus Bokrantz , Jimmy Olsson

Monitoring the health status of patients in the Intensive Care Unit (ICU) is a critical aspect of providing superior care and treatment. The availability of large-scale electronic health records (EHR) provides machine learning models with…

Artificial Intelligence · Computer Science 2023-05-05 Jun Wu , Xuesong Ye , Chengjie Mou , Weinan Dai

Bottom-Up Hidden Tree Markov Model is a highly expressive model for tree-structured data. Unfortunately, it cannot be used in practice due to the intractable size of its state-transition matrix. We propose a new approximation which lies on…

Machine Learning · Computer Science 2019-06-03 Daniele Castellana , Davide Bacciu

The integration of quantum machine learning with classical deep learning offers promising avenues for medical image analysis by mapping data into high-dimensional Hilbert spaces. However, effectively unifying these distinct paradigms…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Yasmin Rodrigues Sobrinho , João Renato Ribeiro Manesco , João Paulo Papa

Cancer classification based on gene expression increases early diagnosis and recovery, but high-dimensional genes with a small number of samples are a major challenge. This work introduces a new hybrid quantum kernel support vector machine…

Machine Learning · Computer Science 2022-02-25 Essam H. Houssein , Zainab Abohashima , Mohamed Elhoseny , Waleed M. Mohamed

The transcriptomics of cancer tumors are characterized with tens of thousands of gene expression features. Patient prognosis or tumor stage can be assessed by machine learning techniques like supervised classification tasks given a gene…

Machine Learning · Computer Science 2020-04-13 Martin Palazzo , Patricio Yankilevich , Pierre Beauseroy

Breast cancer is the most commonly occurring cancer worldwide. This cancer caused 670,000 deaths globally in 2022, as reported by the WHO. Yet since health officials began routine mammography screening in age groups deemed at risk in the…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Mahmudul Hasan

Accurate tumor classification is essential for selecting effective treatments, but current methods have limitations. Standard tumor grading, which categorizes tumors based on cell differentiation, is not recommended as a stand-alone…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Marianne Abémgnigni Njifon , Tobias Weber , Viktor Bezborodov , Tyll Krueger , Dominic Schuhmacher

Tumor protein P53 is believed to be involved in over half of human cancers cases, the prediction of malignancies plays essential roles not only in advance detection for cancer, but also in discovering effective prevention and treatment of…

Computational Engineering, Finance, and Science · Computer Science 2013-10-09 Ayad Ghany Ismaeel