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The learning process of classical machine learning algorithms is tuned by hyperparameters that need to be customized to best learn and generalize from an input dataset. In recent years, Quantum Machine Learning (QML) has been gaining…

Quantum machine learning (QML) is an emerging field that investigates the capabilities of quantum computers for learning tasks. While QML models can theoretically offer advantages such as exponential speed-ups, challenges in data loading…

Quantum Physics · Physics 2025-11-03 Florian J. Kiwit , Bernhard Jobst , Andre Luckow , Frank Pollmann , Carlos A. Riofrío

At the intersection of machine learning and quantum computing, Quantum Machine Learning (QML) has the potential of accelerating data analysis, especially for quantum data, with applications for quantum materials, biochemistry, and…

Quantum Physics · Physics 2023-03-17 M. Cerezo , Guillaume Verdon , Hsin-Yuan Huang , Lukasz Cincio , Patrick J. Coles

Quantum Machine Learning(QML) is developed by combining quantum mechanics principles with classical machine learning techniques in a hybrid framework that can give faster, exponential, more efficient power of quantum computing with the data…

Quantum Physics · Physics 2026-01-27 Pallab Biswas , Tamal Maity

The feature vector mapping used to represent chemical systems is a key factor governing the superior data-efficiency of kernel based quantum machine learning (QML) models applicable throughout chemical compound space. Unfortunately, the…

Chemical Physics · Physics 2023-08-02 Danish Khan , Stefan Heinen , O. Anatole von Lilienfeld

Accurate simulations of atomistic systems from first principles are limited by computational cost. In high-throughput settings, machine learning can reduce these costs significantly by accurately interpolating between reference…

Chemical Physics · Physics 2022-11-28 Haoyan Huo , Matthias Rupp

High-throughput data generation methods and machine learning (ML) algorithms have given rise to a new era of computational materials science by learning relationships among composition, structure, and properties and by exploiting such…

We present a quantum-in-quantum embedding strategy coupled to machine learning potentials to improve on the accuracy of quantum-classical hybrid models for the description of large molecules. In such hybrid models, relevant structural…

Several proposals have been recently introduced to implement Quantum Machine Learning (QML) algorithms for the analysis of classical data sets employing variational learning means. There has been, however, a limited amount of work on the…

Quantum Physics · Physics 2022-10-04 Francesco Scala , Stefano Mangini , Chiara Macchiavello , Daniele Bajoni , Dario Gerace

An outstanding challenge in chemical computation is the many-electron problem where computational methodologies scale prohibitively with system size. The energy of any molecule can be expressed as a weighted sum of the energies of…

Chemical Physics · Physics 2023-01-03 LeeAnn M. Sager-Smith , David A. Mazziotti

Recent advancements in quantum computing (QC) and machine learning (ML) have garnered significant attention, leading to substantial efforts toward the development of quantum machine learning (QML) algorithms to address a variety of complex…

Quantum Physics · Physics 2024-12-18 Samuel Yen-Chi Chen

Quantum machine learning (QML) leverages quantum states for data encoding, with key approaches being explicit models that use parameterized quantum circuits and implicit models that use quantum kernels. Implicit models often have lower…

Quantum Physics · Physics 2025-12-08 Akimoto Nakayama , Hayata Morisaki , Kosuke Mitarai , Hiroshi Ueda , Keisuke Fujii

We introduce property-independent kernels for machine learning modeling of arbitrarily many molecular properties. The kernels encode molecular structures for training sets of varying size, as well as similarity measures sufficiently diffuse…

Chemical Physics · Physics 2015-03-18 Raghunathan Ramakrishnan , O. Anatole von Lilienfeld

High-throughput approximations of quantum mechanics calculations and combinatorial experiments have been traditionally used to reduce the search space of possible molecules, drugs and materials. However, the interplay of structural and…

Quantum Physics · Physics 2019-10-29 Alain Tchagang , Julio Valdés

We propose machine learning (ML) models to predict the electron density -- the fundamental unknown of a material's ground state -- across the composition space of concentrated alloys. From this, other physical properties can be inferred,…

Quantum machine learning (QML) investigates how quantum phenomena can be exploited in order to learn data in an alternative way, \textit{e.g.} by means of a quantum computer. While recent results evidence that QML models can potentially…

Quantum Physics · Physics 2024-07-10 Y. Cordero , S. Biswas , F. Vilariño , M. Bilkis

Understanding the theoretical capabilities and limitations of quantum machine learning (QML) models to solve machine learning tasks is crucial to advancing both quantum software and hardware developments. Similarly to the classical setting,…

Quantum Physics · Physics 2026-03-31 Qiuhao Chen , Yuling Jiao , Yinan Li , Xiliang Lu , Jerry Zhijian Yang

Quantum machine learning (QML) is a rapidly growing field that combines quantum computing principles with traditional machine learning. It seeks to revolutionize machine learning by harnessing the unique capabilities of quantum mechanics…

Quantum Physics · Physics 2024-11-15 Jun Qi , Chao-Han Yang , Samuel Yen-Chi Chen , Pin-Yu Chen

Binding free energies are a key element in understanding and predicting the strength of protein--drug interactions. While classical free energy simulations yield good results for many purely organic ligands, drugs including transition metal…

The development of quantum computers has been the stimulus that enables the realization of Quantum Machine Learning (QML), an area that integrates the calculational framework of quantum mechanics with the adaptive properties of classical…

Computational Engineering, Finance, and Science · Computer Science 2025-09-04 Bhavna Bose , Saurav Verma