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Disease progression modeling aims to characterize and predict how a patient's disease complications worsen over time based on longitudinal electronic health records (EHRs). For diseases such as type 2 diabetes, accurate progression modeling…

Artificial Intelligence · Computer Science 2026-03-31 Tingsong Xiao , Yao An Lee , Zelin Xu , Yupu Zhang , Zibo Liu , Yu Huang , Jiang Bian , Jingchuan Guo , Zhe Jiang

We propose a unified framework for delay differential equations (DDEs) based on deep neural networks (DNNs) - the neural delay differential equations (NDDEs), aimed at solving the forward and inverse problems of delay differential…

Machine Learning · Computer Science 2024-08-27 Housen Wang , Yuxing Chen , Sirong Cao , Xiaoli Wang , Qiang Liu

While tumor dynamic modeling has been widely applied to support the development of oncology drugs, there remains a need to increase predictivity, enable personalized therapy, and improve decision-making. We propose the use of Tumor Dynamic…

Quantitative Methods · Quantitative Biology 2023-10-24 Mark Laurie , James Lu

We propose a novel second-order optimization framework for training the emerging deep continuous-time models, specifically the Neural Ordinary Differential Equations (Neural ODEs). Since their training already involves expensive gradient…

Machine Learning · Computer Science 2021-11-09 Guan-Horng Liu , Tianrong Chen , Evangelos A. Theodorou

Neural ordinary differential equations (ODEs) are an emerging class of deep learning models for dynamical systems. They are particularly useful for learning an ODE vector field from observed trajectories (i.e., inverse problems). We here…

Machine Learning · Computer Science 2023-05-23 Katharina Ott , Michael Tiemann , Philipp Hennig

Partial differential equations (PDEs) are fundamental to modeling complex and nonlinear physical phenomena, but their numerical solution often requires significant computational resources, particularly when a large number of forward full…

Computational Physics · Physics 2025-07-08 Qibang Liu , Seid Koric

Deep Neural Networks (DNNs) have recently achieved great success in many tasks, which encourages DNNs to be widely used as a machine learning service in model sharing scenarios. However, attackers can easily generate adversarial examples…

Machine Learning · Computer Science 2019-07-17 Xiaowei Zhou , Ivor W. Tsang , Jie Yin

We present a novel approach for training deep neural networks in a Bayesian way. Classical, i.e. non-Bayesian, deep learning has two major drawbacks both originating from the fact that network parameters are considered to be deterministic.…

Machine Learning · Statistics 2019-03-11 Konstantin Posch , Jan Steinbrener , Jürgen Pilz

Accurate estimation of aleatoric and epistemic uncertainty is crucial to build safe and reliable systems. Traditional approaches, such as dropout and ensemble methods, estimate uncertainty by sampling probability predictions from different…

Machine Learning · Computer Science 2020-10-23 Bertrand Charpentier , Daniel Zügner , Stephan Günnemann

Recent work in deep learning focuses on solving physical systems in the Ordinary Differential Equation or Partial Differential Equation. This current work proposed a variant of Convolutional Neural Networks (CNNs) that can learn the hidden…

Machine Learning · Computer Science 2021-11-02 Mansura Habiba , Barak A. Pearlmutter

Ordinary differential equations (ODEs), via their induced flow maps, provide a powerful framework to parameterize invertible transformations for the purpose of representing complex probability distributions. While such models have achieved…

Statistics Theory · Mathematics 2023-09-06 Youssef Marzouk , Zhi Ren , Sven Wang , Jakob Zech

Poverty is a complex dynamic challenge that cannot be adequately captured using predefined differential equations. Nowadays, artificial machine learning (ML) methods have demonstrated significant potential in modelling real-world dynamical…

Dynamical Systems · Mathematics 2026-04-02 Sandeep Kumar Samota , Snehashish Chakraverty , Narayan Sethi

Multivariate time series forecasting is an important machine learning problem across many domains, including predictions of solar plant energy output, electricity consumption, and traffic jam situation. Temporal data arise in these…

Machine Learning · Computer Science 2018-04-20 Guokun Lai , Wei-Cheng Chang , Yiming Yang , Hanxiao Liu

Neural CDEs provide a natural way to process the temporal evolution of irregular time series. The number of function evaluations (NFE) is these systems' natural analog of depth (the number of layers in traditional neural networks). It is…

Machine Learning · Computer Science 2026-01-27 Ilya Kuleshov , Evgenia Romanenkova , Vladislav Zhuzhel , Galina Boeva , Evgeni Vorsin , Alexey Zaytsev

Smooth dynamics interrupted by discontinuities are known as hybrid systems and arise commonly in nature. Latent ODEs allow for powerful representation of irregularly sampled time series but are not designed to capture trajectories arising…

Machine Learning · Computer Science 2021-06-11 Ruian Shi , Quaid Morris

A novel way of using neural networks to learn the dynamics of time delay systems from sequential data is proposed. A neural network with trainable delays is used to approximate the right hand side of a delay differential equation. We relate…

Machine Learning · Computer Science 2022-08-29 Xunbi A. Ji , Gabor Orosz

To model time series accurately is important within a wide range of fields. As the world is generally too complex to be modelled exactly, it is often meaningful to assess the probability of a dynamical system to be in a specific state. This…

Machine Learning · Computer Science 2023-03-16 Mari Dahl Eggen , Alise Danielle Midtfjord

Forecasting time series and time-dependent data is a common problem in many applications. One typical example is solving ordinary differential equation (ODE) systems $\dot{x}=F(x)$. Oftentimes the right hand side function $F(x)$ is not…

Computational Physics · Physics 2019-10-14 Artem Chashchin , Mikhail Botchev , Ivan Oseledets , George Ovchinnikov

Recurrent neural networks (RNN) as used in machine learning are commonly formulated in discrete time, i.e. as recursive maps. This brings a lot of advantages for training models on data, e.g. for the purpose of time series prediction or…

Dynamical Systems · Mathematics 2020-07-02 Zahra Monfared , Daniel Durstewitz

To understand the fundamental trade-offs between training stability, temporal dynamics and architectural complexity of recurrent neural networks~(RNNs), we directly analyze RNN architectures using numerical methods of ordinary differential…

Machine Learning · Computer Science 2019-05-01 Murphy Yuezhen Niu , Lior Horesh , Isaac Chuang