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Traditional drug discovery pipeline takes several years and cost billions of dollars. Deep generative and predictive models are widely adopted to assist in drug development. Classical machines cannot efficiently produce atypical patterns of…

Emerging Technologies · Computer Science 2021-04-05 Junde Li , Mahabubul Alam , Congzhou M Sha , Jian Wang , Nikolay V. Dokholyan , Swaroop Ghosh

Deep generative chemistry models emerge as powerful tools to expedite drug discovery. However, the immense size and complexity of the structural space of all possible drug-like molecules pose significant obstacles, which could be overcome…

Quantum Physics · Physics 2023-08-15 A. I. Gircha , A. S. Boev , K. Avchaciov , P. O. Fedichev , A. K. Fedorov

Learning interpretable representations of data remains a central challenge in deep learning. When training a deep generative model, the observed data are often associated with certain categorical labels, and, in parallel with learning to…

Machine Learning · Computer Science 2019-10-01 Yifan Xue , Michael Ding , Xinghua Lu

Variational Quantum Circuits (VQC) lie at the forefront of quantum machine learning research. Still, the use of quantum networks for real data processing remains challenging as the number of available qubits cannot accommodate a large…

Quantum Physics · Physics 2024-09-06 G. Maragkopoulos , A. Mandilara , A. Tsili , D. Syvridis

An important task in quantum generative machine learning is to model the probability distribution of measurements of many-body quantum systems. Classical generative models, such as generative adversarial networks (GANs) and variational…

Quantum Physics · Physics 2023-05-19 Anantha Rao , Dhiraj Madan , Anupama Ray , Dhinakaran Vinayagamurthy , M. S. Santhanam

Variational autoencoders (VAEs) are fundamental for generative modeling and image reconstruction, yet their performance often struggles to maintain high fidelity in reconstructions. This study introduces a hybrid model, quantum variational…

Computer Vision and Pattern Recognition · Computer Science 2025-03-10 Farina Riaz , Fakhar Zaman , Hajime Suzuki , Sharif Abuadbba , David Nguyen

A major challenge in quantum computing is its application to large real-world datasets due to scarce quantum hardware resources. One approach to enabling tractable quantum models for such datasets involves finding low-dimensional…

Quantum Physics · Physics 2025-04-11 Gaoyuan Wang , Jonathan Warrell , Prashant S. Emani , Mark Gerstein

Recent progress in quantum algorithms and hardware indicates the potential importance of quantum computing in the near future. However, finding suitable application areas remains an active area of research. Quantum machine learning is…

Machine Learning · Computer Science 2020-07-16 Nicholas Gao , Max Wilson , Thomas Vandal , Walter Vinci , Ramakrishna Nemani , Eleanor Rieffel

Variational autoencoders (VAEs) are powerful generative models with the salient ability to perform inference. Here, we introduce a quantum variational autoencoder (QVAE): a VAE whose latent generative process is implemented as a quantum…

Classical machine learning often struggles with complex, high-dimensional data. Quantum machine learning offers a potential solution, promising more efficient processing. The quantum convolutional neural network (QCNN), a hybrid algorithm,…

Quantum Physics · Physics 2025-07-25 Hinako Asaoka , Kazue Kudo

One noted issue of vector-quantized variational autoencoder (VQ-VAE) is that the learned discrete representation uses only a fraction of the full capacity of the codebook, also known as codebook collapse. We hypothesize that the training…

Quantum autoencoder is a quantum neural network model for compressing information stored in quantum states. However, one needs to process information stored in quantum circuits for many tasks in the emerging quantum information technology.…

Quantum Physics · Physics 2024-03-29 Jun Wu , Hao Fu , Mingzheng Zhu , Haiyue Zhang , Wei Xie , Xiang-Yang Li

The frequent interactions between quantum computing and machine learning revolutionize both fields. One prototypical achievement is the quantum auto-encoder (QAE), as the leading strategy to relieve the curse of dimensionality ubiquitous in…

Quantum Physics · Physics 2024-10-03 Yuxuan Du , Dacheng Tao

Generative learning models in medical research are crucial in developing training data for deep learning models and advancing diagnostic tools, but the problem of high-quality, diverse images is an open topic of research. Quantum-enhanced…

Quantum Physics · Physics 2025-08-14 Kübra Yeter-Aydeniz , Nora M. Bauer , Pranay Jain , Max Masnick

Interpretable machine learning is rapidly becoming a crucial tool for scientific discovery. Among existing approaches, variational autoencoders (VAEs) have shown promise in extracting the hidden physical features of some input data, with no…

De novo drug design with desired biological activities is crucial for developing novel therapeutics for patients. The drug development process is time and resource-consuming, and it has a low probability of success. Recent advances in…

The development of quantum-classical hybrid (QCH) algorithms is critical to achieve state-of-the-art computational models. A QCH variational autoencoder (QVAE) was introduced in Ref. [1] by some of the authors of this paper. QVAE consists…

We present two deep generative models based on Variational Autoencoders to improve the accuracy of drug response prediction. Our models, Perturbation Variational Autoencoder and its semi-supervised extension, Drug Response Variational…

Machine Learning · Statistics 2017-07-07 Ladislav Rampasek , Daniel Hidru , Petr Smirnov , Benjamin Haibe-Kains , Anna Goldenberg

Deep neural networks with discrete latent variables offer the promise of better symbolic reasoning, and learning abstractions that are more useful to new tasks. There has been a surge in interest in discrete latent variable models, however,…

Machine Learning · Computer Science 2018-07-23 Aurko Roy , Ashish Vaswani , Arvind Neelakantan , Niki Parmar

Vector-Quantized Variational Autoencoders (VQ-VAE)[1] provide an unsupervised model for learning discrete representations by combining vector quantization and autoencoders. In this paper, we study the use of VQ-VAE for representation…

Image and Video Processing · Electrical Eng. & Systems 2019-03-05 Hanwei Wu , Markus Flierl
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