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Biology stores information and computes at the molecular scale, yet the ways in which it does so are often distinct from human-engineered computers. Mapping biological computation onto architectures familiar to computer science remains an…

Biological Physics · Physics 2026-03-31 Jan Kocka , Kabir Husain , Jaime Agudo-Canalejo

I give a quick overview of some of the theoretical background necessary for using modern non-equilibrium statistical physics to investigate the thermodynamics of computation. I first present some of the necessary concepts from information…

Statistical Mechanics · Physics 2019-06-20 David H. Wolpert

Algorithmic cooling is a potentially important technique for making scalable NMR quantum computation feasible in practice. Given the constraints imposed by this approach to quantum computing, the most likely cooling algorithms to be…

Quantum Physics · Physics 2007-05-23 Phillip Kaye

Thermodynamics is a branch of science blessed by an unparalleled combination of generality of scope and formal simplicity. Based on few natural assumptions together with the four laws, it sets the boundaries between possible and impossible…

Quantum Physics · Physics 2014-02-06 Luis A. Correa , José P. Palao , Daniel Alonso , Gerardo Adesso

The aim of this paper is to propose an alternative behavioural definition of computation (and of a computer) based simply on whether a system is capable of reacting to the environment-the input-as reflected in a measure of programmability.…

Logic in Computer Science · Computer Science 2012-11-26 Hector Zenil

According to the Landauer principle, any logically irreversible process accompanies entropy production, which results in heat dissipation in the environment. Erasing of information, one of the primary logically irreversible processes, has a…

Quantum Physics · Physics 2025-08-05 Pritam Chattopadhyay , Avijit Misra , Tanmoy Pandit , Goutam Paul

With the advent of high-throughput profiling methods, interest in reverse engineering the structure and dynamics of biochemical networks is high. Recently an algorithm for reverse engineering of biochemical networks was developed by…

Quantitative Methods · Quantitative Biology 2010-01-18 Edgar Delgado-Eckert

The unavoidable irreversible losses of power in a heat engine are found to be of quantum origin. Following thermodynamic tradition a model quantum heat engine operating by the Otto cycle is analyzed. The working medium of the model is…

Quantum Physics · Physics 2009-11-13 Yair Rezek , Ronnie Kosloff

The promise of chemical computation lies in controlling systems incompatible with traditional electronic micro-controllers, with applications in synthetic biology and nano-scale manufacturing. Computation is typically embedded in…

Emerging Technologies · Computer Science 2019-02-11 Keenan Breik , Chris Thachuk , Marijn Heule , David Soloveichik

Molecular machines consist of either a single protein or a macromolecular complex composed of protein and RNA molecules. Just like their macroscopic counterparts, each of these nano-machines has an engine that "transduces" input energy into…

Biological Physics · Physics 2012-03-15 Debashish Chowdhury

Experiments with superconducting quantum processors have successfully demonstrated the basic functions needed for quantum computation and evidence of utility, albeit without a sizable array of error-corrected qubits. The realization of the…

Provided that there is no theoretical frame for complex engineered systems (CES) as yet, this paper claims that bio-inspired engineering can help provide such a frame. Within CES bio-inspired systems play a key role. The disclosure from…

Other Computer Science · Computer Science 2011-10-18 Nelson Alfonso Gómez-Cruz , Carlos Eduardo Maldonado

Current experiments are taking the first steps toward noise-resilient logical qubits. Crucially, a quantum computer must not merely store information, but also process it. A fault-tolerant computational procedure ensures that errors do not…

Quantum Physics · Physics 2018-11-13 Earl T. Campbell , Barbara M. Terhal , Christophe Vuillot

Memory latency, bandwidth, capacity, and energy increasingly limit performance. In this paper, we reconsider proposed system architectures that consist of huge (many-terabyte to petabyte scale) memories shared among large numbers of CPUs.…

Hardware Architecture · Computer Science 2025-09-24 Samuel Dayo , Shuhan Liu , Peijing Li , Philip Levis , Subhasish Mitra , Thierry Tambe , David Tennenhouse , H. -S. Philip Wong

We consider nano-sized artificial or biological machines working in steady state enforced by imposing non-equilibrium concentrations of solutes or by applying external forces, torques or electric fields. For unicyclic and strongly coupled…

Statistical Mechanics · Physics 2015-05-20 Udo Seifert

Engineered micro- and nanomechanical resonators with ultra-low dissipation constitute the ideal systems for applications ranging from high-precision sensing such as magnetic resonance force microscopy, to quantum transduction between…

Mesoscale and Nanoscale Physics · Physics 2021-10-27 Dennis Høj , Fengwen Wang , Wenjun Gao , Ulrich Busk Hoff , Ole Sigmund , Ulrik Lund Andersen

Quantifying energy flows at nanometer scales promises to guide future research in a variety of disciplines, from microscopic control and manipulation, to autonomously operating molecular machines. A general understanding of the…

Statistical Mechanics · Physics 2018-11-26 Steven J. Large , Raphaël Chetrite , David A. Sivak

A legend tells that once Loschmidt asked Boltzmann on what happens to his statistical theory if one inverts the velocities of all particles, so that, due to the reversibility of Newton's equations, they return from the equilibrium to a…

Quantum Physics · Physics 2009-11-07 B. Georgeot , D. L. Shepelyansky

The nanoscopic isothermal machines are not only energy but also information transducers. We show that the generalized fluctuation theorem with information creation and entropy reduction can be fulfilled for the enzymatic molecular machines…

Biological Physics · Physics 2017-02-06 Michal Kurzynski , Przemyslaw Chelminiak

The performance of a molecular motor, characterized by its power output and energy efficiency, is investigated in the motor design space spanned by the stepping rate function and the motor-track interaction potential. Analytic results and…

Soft Condensed Matter · Physics 2018-03-14 Yuhai Tu , Yuansheng Cao