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The discrepancy of a binary string is the maximum (absolute) difference between the number of ones and the number of zeroes over all possible substrings of the given binary string. In this note we determine the minimal discrepancy that a…

Discrete Mathematics · Computer Science 2024-07-25 Nicolás Álvarez , Verónica Becher , Martín Mereb , Ivo Pajor , Carlos Miguel Soto

Large-alphabet strings are common in scenarios such as information retrieval and natural-language processing. The efficient storage and processing of such strings usually introduces several challenges that are not witnessed in…

Data Structures and Algorithms · Computer Science 2024-05-03 Diego Arroyuelo , Gabriel Carmona , Héctor Larrañaga , Francisco Riveros , Carlos Eugenio Rojas-Morales , Erick Sepúlveda

Motivated by polymer-based data-storage platforms that use chains of binary synthetic polymers as the recording media and read the content via tandem mass spectrometers, we propose a new family of codes that allows for both unique string…

Information Theory · Computer Science 2021-06-29 Srilakshmi Pattabiraman , Ryan Gabrys , Olgica Milenkovic

Deterministic two-way transducers capture the class of regular functions. The efficiency of composing two-way transducers has a direct implication in algorithmic problems related to reactive synthesis, where transformation specifications…

Formal Languages and Automata Theory · Computer Science 2024-07-01 Luc Dartois , Paul Gastin , Loïc Germerie Guizouarn , R. Govind , Shankaranarayanan Krishna

We construct codes over the ring $\mathbb{F}_2+u\mathbb{F}_2$ with $u^2=0$. These code are designed for use in DNA computing applications. The codes obtained satisfy the reverse complement constraint, the $GC$ content constraint and avoid…

Information Theory · Computer Science 2012-07-17 Kenza Guenda , T. Aaron Gulliver

DNA synthesis is considered as one of the most expensive components in current DNA storage systems. In this paper, focusing on a common synthesis machine, which generates multiple DNA strands in parallel following a fixed supersequence,we…

Information Theory · Computer Science 2025-05-13 Yajuan Liu , Tolga M. Duman

In this work, we consider the Combinatorial RNA Design problem, a minimal instance of the RNA design problem which aims at finding a sequence that admits a given target as its unique base pair maximizing structure. We provide complete…

Quantitative Methods · Quantitative Biology 2015-06-22 Jozef Haleš , Ján Maňuch , Yann Ponty , Ladislav Stacho

In this paper we study codes for correcting deletable errors in binary words, where each bit is either retained, substituted, erased or deleted and the total number of errors is much smaller compared to the length of the codeword. We…

Information Theory · Computer Science 2021-03-02 Ghurumuruhan Ganesan

In DNA-based data storage, DNA codes with biochemical constraints and error correction are designed to protect data reliability. Single-stranded DNA sequences with secondary structure avoidance (SSA) help to avoid undesirable secondary…

Information Theory · Computer Science 2023-07-04 Shu Liu , Chaoping Xing , Yaqian Zhang

Generation of an (arbitrarily) long string of bits unique to a given finite-length numerical seed is of great value in the field of random number generation, computer simulations, and other areas of computer science. Extending this idea…

Cryptography and Security · Computer Science 2013-01-10 S. P. Christmas , R. M. Leidich

This paper presents a storage-efficient learning model titled Recursive Binary Neural Networks for sensing devices having a limited amount of on-chip data storage such as < 100's kilo-Bytes. The main idea of the proposed model is to…

Neural and Evolutionary Computing · Computer Science 2017-09-18 Tianchan Guan , Xiaoyang Zeng , Mingoo Seok

String matching algorithm plays the vital role in the Computational Biology. The functional and structural relationship of the biological sequence is determined by similarities on that sequence. For that, the researcher is supposed to aware…

Data Structures and Algorithms · Computer Science 2014-01-30 Pandiselvam. P , Marimuthu. T , Lawrance. R

As a medium for cold data storage, DNA stands out as it promises significant gains in storage capacity and lifetime. However, it comes with its own data processing challenges to overcome. Constrained codes over the DNA alphabet…

Information Theory · Computer Science 2025-10-08 Canberk İrimağzı , Ahmed Hareedy

We study the complexity of the problem of searching for a set of patterns that separate two given sets of strings. This problem has applications in a wide variety of areas, most notably in data mining, computational biology, and in…

Computational Complexity · Computer Science 2016-12-20 Giuseppe Lancia , Luke Mathieson , Pablo Moscato

This paper is concerned with the problem of error-free communication over the i.i.d. duplication channel which acts on a transmitted sequence $ x_1 \cdots x_n $ by inserting a random number of copies of each symbol $ x_i $ next to the…

Information Theory · Computer Science 2020-08-13 Mladen Kovačević

Motivated by applications in DNA-based storage and communication systems, we study deletion and insertion errors simultaneously in a burst. In particular, we study a type of error named $t$-deletion-$s$-insertion-burst ($(t,s)$-burst for…

Information Theory · Computer Science 2022-11-23 Ziyang Lu , Yiwei Zhang

Tandem duplication is an evolutionary process whereby a segment of DNA is replicated and proximally inserted. The different configurations that can arise from this process give rise to some interesting combinatorial questions. Firstly, we…

Combinatorics · Mathematics 2016-11-25 L Penso-Dolfin , CD Greenman

Genomic evolution can be viewed as string-editing processes driven by mutations. An understanding of the statistical properties resulting from these mutation processes is of value in a variety of tasks related to biological sequence data,…

Information Theory · Computer Science 2018-12-07 Hao Lou , Farzad Farnoud , Moshe Schwartz , Jehoshua Bruck

DNA data storage systems encode digital data into DNA strands, enabling dense and durable storage. Efficient data retrieval depends on coverage depth, a key performance metric. We study the random access coverage depth problem and focus on…

Information Theory · Computer Science 2025-07-29 Şeyma Bodur , Stefano Lia , Hiram H. López , Rati Ludhani , Alberto Ravagnani , Lisa Seccia

Recently, DNA storage has surfaced as a promising alternative for data storage, presenting notable benefits in terms of storage capacity, cost-effectiveness in maintenance, and the capability for parallel replication. Mathematically, the…

Information Theory · Computer Science 2024-01-31 Yi Lu , Yun Ma , Chenghao Li , Xin Zhang , Guangxiang Si