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The field of machine learning for drug discovery is witnessing an explosion of novel methods. These methods are often benchmarked on simple physicochemical properties such as solubility or general druglikeness, which can be readily…

This paper presents the philosophy, design and feature-set of Neural Network Distiller, an open-source Python package for DNN compression research. Distiller is a library of DNN compression algorithms implementations, with tools, tutorials…

Machine Learning · Computer Science 2019-10-29 Neta Zmora , Guy Jacob , Lev Zlotnik , Bar Elharar , Gal Novik

partycls is a Python framework for cluster analysis of systems of interacting particles. By grouping particles that share similar structural or dynamical properties, partycls enables rapid and unsupervised exploration of the system's…

Computational Physics · Physics 2021-11-22 Joris Paret , Daniele Coslovich

Molecular docking is a crucial step in drug development, which enables the virtual screening of compound libraries to identify potential ligands that target proteins of interest. However, the computational complexity of traditional docking…

Machine Learning · Computer Science 2024-12-06 Zhangfan Yang , Junkai Ji , Shan He , Jianqiang Li , Tiantian He , Ruibin Bai , Zexuan Zhu , Yew Soon Ong

Designing compounds with desired properties is a key element of the drug discovery process. However, measuring progress in the field has been challenging due to the lack of realistic retrospective benchmarks, and the large cost of…

Biomolecules · Quantitative Biology 2023-06-16 Tobiasz Cieplinski , Tomasz Danel , Sabina Podlewska , Stanislaw Jastrzebski

Numerical stability is a crucial requirement of reliable scientific computing. However, despite the pervasiveness of Python in data science, analyzing large Python programs remains challenging due to the lack of scalable numerical analysis…

Mathematical Software · Computer Science 2024-10-28 Yohan Chatelain , Nigel Yong , Gregory Kiar , Tristan Glatard

PySensors is a Python package for selecting and placing a sparse set of sensors for classification and reconstruction tasks. Specifically, PySensors implements algorithms for data-driven sparse sensor placement optimization for…

Signal Processing · Electrical Eng. & Systems 2021-03-01 Brian M. de Silva , Krithika Manohar , Emily Clark , Bingni W. Brunton , Steven L. Brunton , J. Nathan Kutz

Containers are an emerging technology that hold promise for improving productivity and code portability in scientific computing. We examine Linux container technology for the distribution of a non-trivial scientific computing software stack…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-06-19 Jack S. Hale , Lizao Li , Chris N. Richardson , Garth N. Wells

DisCoPy (Distributional Compositional Python) is an open source toolbox for computing with string diagrams and functors. In particular, the diagram data structure allows to encode various kinds of quantum processes, with functors for…

Quantum Physics · Physics 2022-05-12 Alexis Toumi , Giovanni de Felice , Richie Yeung

Protein--ligand docking is widely used in structure-based discovery, but routine studies often fail at the workflow level rather than at the scoring level. Receptor cleaning, ligand preparation, file conversion, box definition, run…

Quantitative Methods · Quantitative Biology 2026-04-24 Tieu-Long Phan , Lai Hoang Son Le , Thanh-An Pham , Nhu-Ngoc Nguyen Song , Tuyet-Minh Phan , Tuyen Ngoc Truong

Solving the software dependency issue under the HPC environment has always been a difficult task for both computing system administrators and application scientists. This work would like to tackle the issue by introducing the modern…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-09-29 Hsi-En Yu , Weicheng Huang

This paper presents rerankers, a Python library which provides an easy-to-use interface to the most commonly used re-ranking approaches. Re-ranking is an integral component of many retrieval pipelines; however, there exist numerous…

Information Retrieval · Computer Science 2024-09-04 Benjamin Clavié

We introduce Repro, an open-source library which aims at improving the reproducibility and usability of research code. The library provides a lightweight Python API for running software released by researchers within Docker containers which…

Computation and Language · Computer Science 2022-05-02 Daniel Deutsch , Dan Roth

This paper introduces pyRecLab, a software library written in C++ with Python bindings which allows to quickly train, test and develop recommender systems. Although there are several software libraries for this purpose, only a few let…

Software Engineering · Computer Science 2017-07-12 Gabriel Sepulveda , Vicente Dominguez , Denis Parra

Machine learning solutions are very popular in the field of chemoinformatics, where they have numerous applications, such as novel drug discovery or molecular property prediction. Molecular fingerprints are algorithms commonly used for…

Quantitative Methods · Quantitative Biology 2024-04-01 Michał Szafarczyk , Piotr Ludynia , Przemysław Kukla

Applications are increasingly written as dynamic workflows underpinned by an execution framework that manages asynchronous computations across distributed hardware. However, execution frameworks typically offer one-size-fits-all solutions…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-10-18 J. Gregory Pauloski , Klaudiusz Rydzy , Valerie Hayot-Sasson , Ian Foster , Kyle Chard

We introduce a Python framework designed to automate the most common tasks associated with the extraction and upscaling of the statistics of single-impact crater functions to inform coefficients of continuum equations describing surface…

Computational Physics · Physics 2014-10-31 Scott A. Norris

Python has become the prime language for application development in the Data Science and Machine Learning domains. However, data scientists are not necessarily experienced programmers. While Python lets them quickly implement their…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-08-24 Oscar Castro , Pierrick Bruneau , Jean-Sébastien Sottet , Dario Torregrossa

Sparse linear algebra is a cornerstone of many scientific computing and machine learning applications. Python has become a popular choice for these applications due to its simplicity and ease of use. Yet high performance sparse kernels in…

Mathematical Software · Computer Science 2025-10-10 Keshvi Tuteja , Gregor Olenik , Roman Mishchuk , Yu-Hsiang Tsai , Markus Götz , Achim Streit , Hartwig Anzt , Charlotte Debus

Almost all applications stop scaling at some point; those that don't are seldom performant when considering time to solution on anything but aspirational/unicorn resources. Recognizing these tradeoffs as well as greater user functionality…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-06-28 Stephen Hudson , Jeffrey Larson , John-Luke Navarro , Stefan M. Wild
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