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Red blood cells (RBCs) are vital for transporting oxygen from the lungs to the body's tissues through the intricate circulatory system. They achieve this by binding and releasing oxygen molecules to the abundant hemoglobin within their…

Biological Physics · Physics 2025-06-03 Lucas Amoudruz , Athena Economides , Petros Koumoutsakos

Blood rheology and microcirculation are strongly influenced by red blood cell (RBC) aggregation. The aggregability of RBCs can vary significantly due to factors such as their mechanical and membrane surface properties, which are affected by…

Biological Physics · Physics 2025-04-02 M. Puthumana Melepattu , G. Maîtrejean , C. Wagner , T. Podgorski

The nature of blood as a suspension of red blood cells makes computational hemodynamics a demanding task. Our coarse-grained blood model, which builds on a lattice Boltzmann method for soft particle suspensions, enables the study of the…

Soft Condensed Matter · Physics 2011-09-16 Florian Janoschek , Francesca Mancini , Jens Harting , Federico Toschi

Red blood cells (RBCs) from the cord blood of newborn infants have distinctive functions for fetal and infant development. To systematically investigate the biophysical characteristics of individual cord RBCs in newborn infants, a…

Constrictions in blood vessels and microfluidic devices can dramatically change the spatial distribution of passing cells or particles and are commonly used in biomedical cell sorting applications. However, the three-dimensional nature of…

Fluid Dynamics · Physics 2019-12-03 Asena Abay , Steffen M. Recktenwald , Thomas John , Lars Kaestner , Christian Wagner

We present a deformation-dependent propulsion phenomenon for soft particles such as cells in microchannels. It is based on a broken time reversal symmetry generated by a fast forward and slow backward motion of a fluid which does not…

Soft Condensed Matter · Physics 2022-02-22 Winfried Schmidt , Andre Förtsch , Matthias Laumann , Walter Zimmermann

The functions and elasticities of the cell are largely related to the structures of the cytoskeletons underlying the lipid bi-layer. Among various cell types, the Red Blood Cell (RBC) possesses a relatively simple cytoskeletal structure.…

Biological Physics · Physics 2016-01-20 Lipeng Lai , Xiaofeng Xu , Chwee Teck Lim , Jianshu Cao

Margination, a fundamental process in which leukocytes migrate from the flowing blood to the vessel wall, is well-documented in physiology. However, it is still an open question on how the differences in cell size and stiffness of white and…

Soft Condensed Matter · Physics 2024-09-05 Revaz D. Chachanidze , Othmane Aouane , Jens Harting , Christian Wagner , Marc Leonetti

The red blood cells or erythrocytes are biconcave shaped cells and consist mostly in a membrane delimiting a cytosol with a high concentration in hemoglobin. This membrane is highly deformable and allows the cells to go through narrow…

Biological Physics · Physics 2012-06-27 Benjamin Mauroy

We propose a modified suspension balance model (SBM) for the flow of red blood cells (RBCs) and other deformable particle suspensions in confined geometries. Specifically, the method includes the hydrodynamic lift force generated by…

Centrifugation is a commonly performed laboratory procedure that helps to separate blood cells such as $RBCs$, $WBCs$, and platelets from plasma or serum. Although centrifugation is a routine procedure in most medical laboratories, the…

Biological Physics · Physics 2023-01-25 Mesfin Taye

The tumbling to tank-treading (TB-TT) transition for red blood cells (RBCs) has been widely investigated, with a main focus on the effects of the viscosity ratio $\lambda$ (i.e., the ratio between the viscosities of the fluids inside and…

Soft Condensed Matter · Physics 2021-10-04 Fabio Guglietta , Marek Behr , Luca Biferale , Giacomo Falcucci , Mauro Sbragaglia

Red blood cell (RBC) deformation is the consequence of several diseases, including sickle cell anemia, which causes recurring episodes of pain and severe pronounced anemia. Monitoring patients with these diseases involves the observation of…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Wilkie Delgado-Font , Miriela Escobedo-Nicot , Manuel González-Hidalgo , Silena Herold-Garcia , Antoni Jaume-i-Capó , Arnau Mir

Biconcave-discoid (empirical shape of a red blood cell) capsule finds numerous applications in the field of bio-fluid dynamics and rheology, apart from understanding the behavior of red blood cells (RBC) in blood flow. A detailed analysis…

Soft Condensed Matter · Physics 2018-12-11 Sudip Das , Shivraj D. Deshmukh , Rochish M Thaokar

Background and Objective: The role of red blood cell dynamics is emphasised in certain cardiovascular diseases, and thus needs to be closely studied. A multiphase model of blood flow allows the resolution of locally varying density of red…

Fluid Dynamics · Physics 2021-10-07 Konstantinos G. Lyras , Jack Lee

We present rheology experiments on dilute solutions of vesicles and red blood cells (RBC). Varying the viscosity ratio $\lambda$ between internal and external fluids, the microscopic dynamics of suspended objects can be qualitatively…

Soft Condensed Matter · Physics 2007-07-31 Victoria Vitkova , Maud-Alix Mader , Chaouqi Misbah , Thomas Podgorski

We test the ability of a low-dimensional turbulence model to predict how dynamics of large-scale coherent structures such as convection rolls change in different cell geometries. We performed Rayleigh-B\'enard convection experiments in a…

Fluid Dynamics · Physics 2020-07-01 Dandan Ji , Eric Brown

Distant spreading of primary lesions is modulated by the vascular dynamics of circulating tumor cells (CTCs) and their ability to establish metastatic niches. While the mechanisms regulating CTC homing in specific tissues are yet to be…

Soft Condensed Matter · Physics 2019-07-23 Pieto Lenarda , Alessandro Coclite , Paolo Decuzzi

Flux of rigid or soft particles (such as drops, vesicles, red blood cells, etc.) in a channel is a complex function of particle concentration, which depends on the details of induced dissipation and suspension structure due to hydrodynamic…

Based on symmetry consideration of migration and shape deformations, we formulate phenomenologically the dynamics of cell crawling in two dimensions. Forces are introduced to change the cell shape. The shape deformations induce migration of…

Biological Physics · Physics 2016-03-23 Takao Ohta , Mitsusuke Tarama , Masaki Sano