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The performance of most error-correction algorithms that operate on genomic sequencer reads is dependent on the proper choice of its configuration parameters, such as the value of k in k-mer based techniques. In this work, we target the…

Neural and Evolutionary Computing · Computer Science 2019-01-01 Mustafa Abdallah , Ashraf Mahgoub , Saurabh Bagchi , Somali Chaterji

Motivation: Next-generation sequencing tools have enabled producing of huge amount of genomic information at low cost. Unfortunately, presence of sequencing errors in such data affects quality of downstream analyzes. Accuracy of them can be…

Genomics · Quantitative Biology 2017-03-03 Maciej Dlugosz , Sebastian Deorowicz

Fine-tuning large language models (LLMs) typically relies on producing large sets of input-output pairs. Yet for a given question, there can be many valid outputs. In practice, these outputs are often derived by distilling knowledge from…

Computation and Language · Computer Science 2025-08-28 Xuan Ren , Qi Chen , Lingqiao Liu

DNA sequence alignment involves assigning short DNA reads to the most probable locations on an extensive reference genome. This process is crucial for various genomic analyses, including variant calling, transcriptomics, and epigenomics.…

This paper introduces Exact Linear Attention (ELA), a mechanism that achieves linear computational complexity for Transformer attention by exploiting the exact decomposition property of kernel functions, thereby eliminating approximation…

Machine Learning · Computer Science 2026-05-21 Weinuo Ou

The third-generation long reads sequencing technologies, such as PacBio and Nanopore, have great advantages over second-generation Illumina sequencing in de novo assembly studies. However, due to the inherent low base accuracy,…

Genomics · Quantitative Biology 2020-03-27 Hengchao Wang , Bo Liu , Yan Zhang , Fan Jiang , Yuwei Ren , Lijuan Yin , Hangwei Liu , Sen Wang , Wei Fan

Increasing the input length has been a driver of progress in language modeling with transformers. We identify conditions where shorter inputs are not harmful, and achieve perplexity and efficiency improvements through two new methods that…

Computation and Language · Computer Science 2021-06-04 Ofir Press , Noah A. Smith , Mike Lewis

Modern Transformer-based models frequently suffer from miscalibration, producing overconfident predictions that do not reflect true empirical frequencies. This work investigates the calibration dynamics of LoRA: Low-Rank Adaptation and a…

Computation and Language · Computer Science 2026-03-31 Bartosz Trojan , Filip Gębala

Fine-tuning a Pre-trained Language Model (PLM) on a specific downstream task has been a well-known paradigm in Natural Language Processing. However, with the ever-growing size of PLMs, training the entire model on several downstream tasks…

Computation and Language · Computer Science 2022-12-22 Ali Edalati , Marzieh Tahaei , Ivan Kobyzev , Vahid Partovi Nia , James J. Clark , Mehdi Rezagholizadeh

The study of functional genomics--particularly in non-model organisms has been dramatically improved over the last few years by use of transcriptomes and RNAseq. While these studies are potentially extremely powerful, a computationally…

Genomics · Quantitative Biology 2013-07-25 Matthew D MacManes , Michael B Eisen

Embedding-based Retrieval Models (ERMs) have emerged as a promising framework for large-scale text retrieval problems due to powerful large language models. Nevertheless, fine-tuning ERMs to reach state-of-the-art results can be expensive…

Cancer detection and prognosis relies heavily on medical imaging, particularly CT and PET scans. Deep Neural Networks (DNNs) have shown promise in tumor segmentation by fusing information from these modalities. However, a critical…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Numan Saeed , Shahad Hardan , Muhammad Ridzuan , Nada Saadi , Karthik Nandakumar , Mohammad Yaqub

Quantum computing has the potential to solve problems that are intractable for classical systems, yet the high error rates in contemporary quantum devices often exceed tolerable limits for useful algorithm execution. Quantum Error…

Quantum Physics · Physics 2023-11-28 Hanrui Wang , Pengyu Liu , Kevin Shao , Dantong Li , Jiaqi Gu , David Z. Pan , Yongshan Ding , Song Han

Low-Rank Adaptation (LoRA) has emerged as one of the most widely used parameter-efficient fine-tuning (PEFT) methods for adapting large language models (LLMs) to downstream tasks. While highly effective in single-task settings, it struggles…

Computation and Language · Computer Science 2025-10-14 Bo Cheng , Xu Wang , Jinda Liu , Yi Chang , Yuan Wu

Recently Transformers have provided state-of-the-art performance in sparse matching, crucial to realize high-performance 3D vision applications. Yet, these Transformers lack efficiency due to the quadratic computational complexity of their…

Computer Vision and Pattern Recognition · Computer Science 2022-04-25 Suwichaya Suwanwimolkul , Satoshi Komorita

Transformer models are computationally costly on long sequences since regular attention has quadratic $O(n^2)$ time complexity. We introduce Wavelet-Enhanced Random Spectral Attention (WERSA), a novel mechanism of linear $O(n)$ time…

Machine Learning · Computer Science 2025-07-14 Vincenzo Dentamaro

Quantum Error Correction (QEC) is one of the fundamental problems in quantum computer systems, which aims to detect and correct errors in the data qubits within quantum computers. Due to the presence of unreliable data qubits in existing…

Quantum Physics · Physics 2024-04-08 Yue Zhao

Click-Through Rate (CTR) prediction holds a paramount position in recommender systems. The prevailing ID-based paradigm underperforms in cold-start scenarios due to the skewed distribution of feature frequency. Additionally, the utilization…

Information Retrieval · Computer Science 2024-11-28 Xingmei Wang , Weiwen Liu , Xiaolong Chen , Qi Liu , Xu Huang , Yichao Wang , Xiangyang Li , Yasheng Wang , Zhenhua Dong , Defu Lian , Ruiming Tang

Transformers are considered one of the most important deep learning models since 2018, in part because it establishes state-of-the-art (SOTA) records and could potentially replace existing Deep Neural Networks (DNNs). Despite the remarkable…

Machine Learning · Computer Science 2022-08-23 Hongwu Peng , Shaoyi Huang , Shiyang Chen , Bingbing Li , Tong Geng , Ang Li , Weiwen Jiang , Wujie Wen , Jinbo Bi , Hang Liu , Caiwen Ding

Transformer-based large language models (LLMs) excel in modeling complex language patterns but face significant computational costs during inference, especially with long inputs due to the attention mechanism's memory overhead. We observe…

Computation and Language · Computer Science 2024-10-18 Ruiqing Yan , Linghan Zheng , Xingbo Du , Han Zou , Yufeng Guo , Jianfei Yang
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