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Missing data is a major challenge in clinical research. In electronic medical records, often a large fraction of the values in laboratory tests and vital signs are missing. The missingness can lead to biased estimates and limit our ability…

Machine Learning · Computer Science 2023-04-18 Omer Noy , Ron Shamir

Predictive modeling often uses black box machine learning methods, such as deep neural networks, to achieve state-of-the-art performance. In scientific domains, the scientist often wishes to discover which features are actually important…

Machine Learning · Statistics 2020-08-03 Mukund Sudarshan , Wesley Tansey , Rajesh Ranganath

In many applications, we need to study a linear regression model that consists of a response variable and a large number of potential explanatory variables and determine which variables are truly associated with the response. In 2015,…

Methodology · Statistics 2019-07-23 Jiajie Chen , Anthony Hou , Thomas Y. Hou

The complexity of deep neural networks (DNNs) makes them powerful but also makes them challenging to interpret, hindering their applicability in error-intolerant domains. Existing methods attempt to reason about the internal mechanism of…

Machine Learning · Computer Science 2023-09-28 Winston Chen , William Stafford Noble , Yang Young Lu

The Model-X knockoffs is a practical methodology for variable selection, which stands out from other selection strategies since it allows for the control of the false discovery rate (FDR), relying on finite-sample guarantees. In this…

Selecting important features in high-dimensional survival analysis is critical for identifying confirmatory biomarkers while maintaining rigorous error control. In this paper, we propose a derandomized knockoffs procedure for Cox regression…

Methodology · Statistics 2025-12-15 Rui Liu , Nan Sun

Algorithms that ensure reproducible findings from large-scale, high-dimensional data are pivotal in numerous signal processing applications. In recent years, multivariate false discovery rate (FDR) controlling methods have emerged,…

Methodology · Statistics 2024-01-31 Jasin Machkour , Michael Muma , Daniel P. Palomar

Recently, Barber and Cand\`es laid the theoretical foundation for a general framework for false discovery rate (FDR) control based on the notion of "knockoffs." A closely related FDR control methodology has long been employed in the…

Methodology · Statistics 2022-03-15 Dong Luo , Arya Ebadi , Yilun He , Kristen Emery , William Stafford Noble , Uri Keich

In 2015, Barber and Candes introduced a new variable selection procedure called the knockoff filter to control the false discovery rate (FDR) and prove that this method achieves exact FDR control. Inspired by the work of Barber and Candes…

Methodology · Statistics 2019-07-23 Jiajie Chen , Anthony Hou , Thomas Y. Hou

Controlled variable selection is an important analytical step in various scientific fields, such as brain imaging or genomics. In these high-dimensional data settings, considering too many variables leads to poor models and high costs,…

Methodology · Statistics 2023-10-17 Alexandre Blain , Bertrand Thirion , Olivier Grisel , Pierre Neuvial

This paper introduces a novel Knockoff-guided compressive sensing framework, referred to as \TheName{}, which enhances signal recovery by leveraging precise false discovery rate (FDR) control during the support identification phase. Unlike…

Machine Learning · Statistics 2025-06-02 Xiaochen Zhang , Haoyi Xiong

A variety of methods have been proposed for inference about extreme dependence for multivariate or spatially-indexed stochastic processes and time series. Most of these proceed by first transforming data to some specific extreme value…

Statistics Theory · Mathematics 2018-05-22 James E. Johndrow , Robert L. Wolpert

Topological data analysis (TDA) approaches are becoming increasingly popular for studying the dependence patterns in multivariate time series data. In particular, various dependence patterns in brain networks may be linked to specific tasks…

Methodology · Statistics 2025-12-08 Anass El Yaagoubi Bourakna , Moo K. Chung , Hernando Ombao

Data imputation is crucial for addressing challenges posed by missing values in multivariate time series data across various fields, such as healthcare, traffic, and economics, and has garnered significant attention. Among various methods,…

Machine Learning · Computer Science 2025-01-14 Chunjing Xiao , Xue Jiang , Xianghe Du , Wei Yang , Wei Lu , Xiaomin Wang , Kevin Chetty

We investigate the problem of statistical inference for logistic regression with high-dimensional covariates in settings where dependence among individuals is induced by an underlying Markov random field. Going beyond the pairwise…

Statistics Theory · Mathematics 2026-03-23 Josh Miles , Sohom Bhattacharya

Bayesian computational algorithms tend to scale poorly as data size increases. This has motivated divide-and-conquer-based approaches for scalable inference. These divide the data into subsets, perform inference for each subset in parallel,…

Methodology · Statistics 2025-10-22 Rihui Ou , Lachlan Astfalck , Deborshee Sen , David Dunson

This paper presents a systematic framework for controlling false discovery rate in learning time-varying correlation networks from high-dimensional, non-linear, non-Gaussian and non-stationary time series with an increasing number of…

Methodology · Statistics 2025-12-16 Bufan Li , Lujia Bai , Weichi Wu

Competition-based approach to controlling the false discovery rate (FDR) recently rose to prominence when, generalizing it to sequential hypothesis testing, Barber and Cand\`es used it as part of their knockoff-filter. Control of the FDR…

Methodology · Statistics 2023-02-24 Arya Ebadi , Dong Luo , Jack Freestone , William Stafford Noble , Uri Keich

Temporal difference (TD) learning is a fundamental algorithm for estimating value functions in reinforcement learning. Recent finite-time analyses of TD with linear function approximation quantify its theoretical convergence rate. However,…

Machine Learning · Computer Science 2026-03-04 Yunxiang Li , Mark Schmidt , Reza Babanezhad , Sharan Vaswani

This article studies bootstrap inference for high dimensional weakly dependent time series in a general framework of approximately linear statistics. The following high dimensional applications are covered: (1) uniform confidence band for…

Statistics Theory · Mathematics 2014-08-12 Xianyang Zhang , Guang Cheng