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In randomized trials involving multiple treatments, bivariate survival outcomes present significant analytical challenges for making decisions. This paper addresses the problem of deriving optimal individualized treatment rules to maximize…

Machine Learning · Statistics 2026-05-29 Kun Ren , Yifan Cui , Wen Su

We propose a dynamic allocation procedure that increases power and efficiency when measuring an average treatment effect in sequential randomized trials. Subjects arrive iteratively and are either randomized or paired via a matching…

Methodology · Statistics 2013-05-23 Adam Kapelner , Abba Krieger

This paper shows how to use a randomized saturation experimental design to identify and estimate causal effects in the presence of spillovers--one person's treatment may affect another's outcome--and one-sided non-compliance--subjects can…

Personalized AI-based services involve a population of individual reinforcement learning agents. However, most reinforcement learning algorithms focus on harnessing individual learning and fail to leverage the social learning capabilities…

Machine Learning · Computer Science 2026-03-13 Erfan Mirzaei , Seyed Pooya Shariatpanahi , Alireza Tavakoli , Reshad Hosseini , Majid Nili Ahmadabadi

We develop a mathematical framework to define an optimal individualized treatment rule (ITR) within the context of prioritized outcomes in a randomized controlled trial. Our optimality criterion is based on the framework of generalized…

Methodology · Statistics 2025-06-17 François Petit , Gérard Biau , Raphaël Porcher

This paper considers the estimation of treatment assignment rules when the policy maker faces a general budget or resource constraint. Utilizing the PAC-Bayesian framework, we propose new treatment assignment rules that allow for flexible…

Econometrics · Economics 2023-06-12 Daniel F. Pellatt

Although there is now a large literature on policy evaluation and learning, much of the prior work assumes that the treatment assignment of one unit does not affect the outcome of another unit. Unfortunately, ignoring interference can lead…

Methodology · Statistics 2025-04-02 Yi Zhang , Kosuke Imai

Many public health interventions are conducted in settings where individuals are connected to one another and the intervention assigned to randomly selected individuals may spill over to other individuals they are connected to. In these…

Methodology · Statistics 2026-01-14 Junhan Fang , Donna Spiegelman , Ashley Buchanan , Laura Forastiere

In non-network settings, encouragement designs have been widely used to analyze causal effects of a treatment, policy, or intervention on an outcome of interest when randomizing the treatment was considered impractical or when compliance to…

Methodology · Statistics 2016-09-16 Hyunseung Kang , Guido Imbens

Liberalism-oriented political philosophy reasons that all individuals should be treated equally independently of their protected characteristics. Related work in machine learning has translated the concept of \emph{equal treatment} into…

Machine Learning · Computer Science 2023-10-03 Carlos Mougan , Laura State , Antonio Ferrara , Salvatore Ruggieri , Steffen Staab

Randomized experiments on social networks pose statistical challenges, due to the possibility of interference between units. We propose new methods for estimating attributable treatment effects in such settings. The methods do not require…

Methodology · Statistics 2015-10-13 David S. Choi

A treatment regime is a function that maps individual patient information to a recommended treatment, hence explicitly incorporating the heterogeneity in need for treatment across individuals. Patient responses are dichotomous and can be…

Machine Learning · Statistics 2016-07-07 Yingfei Wang , Warren Powell

We consider the problem of defining the effect of an intervention on a time-varying risk factor or treatment for a disease or a physiological marker; we develop here the latter case. So, the system considered is $(Y,A,C)$, where $Y=(Y_t)$,…

Methodology · Statistics 2019-07-31 Daniel Commenges , Mélanie Prague

Interference occurs when the potential outcomes of a unit depend on the treatment of others. Interference can be highly heterogeneous, where treating certain individuals might have a larger effect on the population's overall outcome. A…

Methodology · Statistics 2025-04-11 Samantha G Dean , Georgia Papadogeorgou , Laura Forastiere

Adjustable autonomy refers to entities dynamically varying their own autonomy, transferring decision-making control to other entities (typically agents transferring control to human users) in key situations. Determining whether and when…

Artificial Intelligence · Computer Science 2011-06-24 D. V. Pynadath , P. Scerri , M. Tambe

In this review, we present econometric and statistical methods for analyzing randomized experiments. For basic experiments we stress randomization-based inference as opposed to sampling-based inference. In randomization-based inference,…

Methodology · Statistics 2017-10-26 Susan Athey , Guido Imbens

In experimental design and causal inference, it may happen that the treatment is not defined on individual experimental units, but rather on pairs or, more generally, on groups of units. For example, teachers may choose pairs of students…

Statistics Theory · Mathematics 2018-01-24 Panos Toulis , Alexander Volfovsky , Edoardo M. Airoldi

Allocation of scarce resources is a recurring challenge for the public sector: something that emerges in areas as diverse as healthcare, disaster recovery, and social welfare. The complexity of these policy domains and the need for meeting…

Computers and Society · Computer Science 2023-10-11 Saba Esnaashari , Jonathan Bright , John Francis , Youmna Hashem , Vincent Straub , Deborah Morgan

In Influence Maximization (IM), the objective is to -- given a budget -- select the optimal set of entities in a network to target with a treatment so as to maximize the total effect. For instance, in marketing, the objective is to target…

Social and Information Networks · Computer Science 2025-06-05 Daan Caljon , Jente Van Belle , Jeroen Berrevoets , Wouter Verbeke

This study investigates the identification power gained by combining experimental data, in which treatment is randomized, with observational data, in which treatment is self-selected, for distributional treatment effect (DTE) parameters.…

Econometrics · Economics 2026-04-24 Shosei Sakaguchi