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Extracting multi-scale information is key to semantic segmentation. However, the classic convolutional neural networks (CNNs) encounter difficulties in achieving multi-scale information extraction: expanding convolutional kernel incurs the…

In recent years, diverging-wave (DW) ultrasound imaging has become a very promising methodology for cardiovascular imaging due to its high temporal resolution. However, if they are limited in number, DW transmits provide lower image quality…

Motivation: Cellular Electron CryoTomography (CECT) enables 3D visualization of cellular organization at near-native state and in sub-molecular resolution, making it a powerful tool for analyzing structures of macromolecular complexes and…

One primary technical challenge in photoacoustic microscopy (PAM) is the necessary compromise between spatial resolution and imaging speed. In this study, we propose a novel application of deep learning principles to reconstruct…

Deep convolutional neural networks (CNNs) for image denoising have recently attracted increasing research interest. However, plain networks cannot recover fine details for a complex task, such as real noisy images. In this paper, we…

The use of deep learning (DL) in medical image analysis has significantly improved the ability to predict lung cancer. In this study, we introduce a novel deep convolutional neural network (CNN) model, named ResNet+, which is based on the…

Background: Three-dimensional, whole heart, balanced steady state free precession (WH-bSSFP) sequences provide delineation of intra-cardiac and vascular anatomy. However, they have long acquisition times. Here, we propose significant speed…

Volumetric imaging by fluorescence microscopy is often limited by anisotropic spatial resolution from inferior axial resolution compared to the lateral resolution. To address this problem, here we present a deep-learning-enabled…

Super-resolution (SR) aims to enhance the quality of low-resolution images and has been widely applied in medical imaging. We found that the design principles of most existing methods are influenced by SR tasks based on real-world images…

Undersampling the k-space data is widely adopted for acceleration of Magnetic Resonance Imaging (MRI). Current deep learning based approaches for supervised learning of MRI image reconstruction employ real-valued operations and…

A deep learning approach to blind denoising of images without complete knowledge of the noise statistics is considered. We propose DN-ResNet, which is a deep convolutional neural network (CNN) consisting of several residual blocks…

Cellular processes are governed by macromolecular complexes inside the cell. Study of the native structures of macromolecular complexes has been extremely difficult due to lack of data. With recent breakthroughs in Cellular electron cryo…

Deep convolutional neural networks (Deep CNN) have achieved hopeful performance for single image super-resolution. In particular, the Deep CNN skip Connection and Network in Network (DCSCN) architecture has been successfully applied to…

Residual networks (ResNets) represent a powerful type of convolutional neural network (CNN) architecture, widely adopted and used in various tasks. In this work we propose an improved version of ResNets. Our proposed improvements address…

With super-resolution optical microscopy, it is now possible to observe molecular interactions in living cells. The obtained images have a very high spatial precision but their overall quality can vary a lot depending on the structure of…

Single-shot imaging with femtosecond X-ray lasers is a powerful measurement technique that can achieve both high spatial and temporal resolution. However, its accuracy has been severely limited by the difficulty of applying conventional…

Magnetic resonance spectroscopic imaging (SI) is a unique imaging technique that provides biochemical information from in vivo tissues. The 1H spectra acquired from several spatial regions are quantified to yield metabolite concentrations…

We present a physics-informed deep learning framework to address common limitations in Confocal Laser Scanning Microscopy (CLSM), such as diffraction limited resolution, noise, and undersampling due to low laser power conditions. The…

In order to address the issue that medical image would suffer from severe blurring caused by the lack of high-frequency details in the process of image super-resolution reconstruction, a novel medical image super-resolution method based on…

In this paper, we aim to reconstruct a full 3D human shape from a single image. Previous vertex-level and parameter regression approaches reconstruct 3D human shape based on a pre-defined adjacency matrix to encode positive relations…