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Molecular imaging refers to a class of noninvasive biomedical imaging techniques with the sensitivity and specificity to image biochemical variations in-vivo. An ideal molecular imaging technique visualizes a biochemical target according to…
We present a technique that uses an ensemble of nitrogen-vacancy (NV) centers in diamond to image magnetic fields with high spatio-temporal resolution and sensitivity. A focused laser beam is raster-scanned using an acousto-optic deflector…
We suggest a novel approach for wide-field imaging of the neural network dynamics of brain slices that uses highly sensitivity magnetometry based on nitrogen-vacancy (NV) centers in diamond. In-vitro recordings in brain slices is a proven…
Single-crystal synthetic diamond sensors have been widely used in radiation dosimetry and beam diagnostics. The foreseen harsh radiation environment in electron-positron colliders at the luminosity frontier requires a thorough investigation…
Optical biosensors based on micro-/nano-fibers are highly valuable for probing and monitoring liquid environments and bioactivity. Most of current optical biosensors, however, are still based on glass, semiconductors, or metallic materials,…
Nitrogen vacancy centers in diamond are among the leading solid state quantum platforms, offering exceptional spatial resolution and sensitivity for applications such as magnetic field sensing, thermometry, and bioimaging. However, in high…
This paper proposes the design of decision models based on Computational Intelligence techniques applied to image sequences of dynamic laser speckle. These models aim to identify image regions of biological specimens illuminated by a…
The investigation of biomolecular interactions at the single-molecule level has emerged as a pivotal research area in life science, particularly through optical, mechanical, and electrochemical approaches. Spins existing widely in…
Magnetocardiography (MCG) has emerged as a sensitive and precise method to diagnose cardiovascular diseases, providing more diagnostic information than traditional technology. However, the sensor limitations of conventional MCG systems,…
Objective: We present magnetomyograms (MMG) of TMS-evoked movement in a human hand, together with a simultaneous surface electromyograph (EMG) and electroencephalograph (EEG) data. Approach: We combined TMS with non-contact magnetic…
The ability to measure weak signals such as pressure, force, electric field, and temperature with nanoscale devices and high spatial resolution offers a wide range of applications in fundamental and applied sciences. Here we present a…
Optically accessible spin-active nanomaterials are promising as quantum nanosensors for probing biological samples. However, achieving bioimaging-level brightness and high-quality spin properties for these materials is challenging and…
Precise assessment of the mechanical properties of soft biological systems at the nanoscale is crucial for understanding physiology, pathology, and developing relevant drugs. Conventional atomic force microscopy (AFM)-based indentation…
Nanomechanical sensors and quantum nanosensors are two rapidly developing technologies that have diverse interdisciplinary applications in biological and chemical analysis and microscopy. For example, nanomechanical sensors based upon…
The design and benchtop operation of a wireless miniature epiretinal stimulator implant is reported. The implant is optically powered and controlled using safe illumination at near-infrared wavelengths. An application-specific integrated…
This paper proposes a novel wireless, battery-free, and label-free biosensor for minimally invasive and non-invasive permittivity sensing for applications such as detecting glucose levels in the interstitial dermal fluid. The miniaturized,…
We present a method of optical magnetometry with parts-per-billion resolution that is able to detect biomagnetic signals generated from the human brain and heart in Earth's ambient environment. Our magnetically silent sensors measure the…
Nitrogen-vacancy (NV) centers show great potentials for nanoscale bio-sensing and bio-imaging. Nevertheless, their envisioned bio-applications suffer from intrinsic background noise due to unavoidable light scattering and autofluorescence…
Quantum sensors based on the nitrogen-vacancy (NV) centre in diamond are rapidly advancing from scientific exploration towards the first generation of commercial applications. While significant progress has been made in developing suitable…
In the intact brain, neural activity can be recorded using sensing electrodes and manipulated using light stimulation. Silicon probes with integrated electrodes and micro-LEDs enable the detection and control of neural activity using a…