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To achieve minimum DNA input and tumor purity requirements for next-generation sequencing (NGS), pathologists visually estimate macrodissection and slide count decisions. Misestimation may cause tissue waste and increased laboratory costs.…
Precision medicine, tailored to individual patients based on their genetics, environment, and lifestyle, shows promise in managing complex diseases like infections. Integrating artificial intelligence (AI) into precision medicine can…
In digital pathology, the spatial context of cells is important for cell classification, cancer diagnosis and prognosis. To model such complex cell context, however, is challenging. Cells form different mixtures, lineages, clusters and…
Computational biology is on the verge of a paradigm shift in its research practice - from a data-based (computational) paradigm to an information-based (cognitive) paradigm. As in the other research fields, this transition is impeded by…
Image analysis and machine learning algorithms operating on multi-gigapixel whole-slide images (WSIs) often process a large number of tiles (sub-images) and require aggregating predictions from the tiles in order to predict WSI-level…
Medical imaging plays an important role in the medical sector in identifying diseases. X-ray, computed tomography (CT) scans, and magnetic resonance imaging (MRI) are a few examples of medical imaging. Most of the time, these imaging…
Foundation models are increasingly developed in computational pathology (CPath) given their promise in facilitating many downstream tasks. While recent studies have evaluated task performance across models, less is known about the structure…
Objective: In this review, we aim to provide an analysis of current cardiac ablation techniques, such as radiofrequency ablation (RF), cryoablation, and pulsed-field ablation (PFA), with a focus on the role of computational modeling in…
Computed Tomography (CT) using synchrotron radiation is a powerful technique that, compared to lab-CT techniques, boosts high spatial and temporal resolution while also providing access to a range of contrast-formation mechanisms. The…
The surge in developing deep learning models for diagnosing skin lesions through image analysis is notable, yet their clinical black faces challenges. Current dermatology AI models have limitations: limited number of possible diagnostic…
Artificial intelligence (AI)-based clinical decision support systems (CDSS) promise to enhance diagnostic accuracy and efficiency in computational pathology. However, human-AI collaboration might introduce automation bias, where users…
The examination of histopathology images is considered to be the gold standard for the diagnosis and stratification of cancer patients. A key challenge in the analysis of such images is their size, which can run into the gigapixels and can…
Computer-aided diagnosis systems hold great promise to aid radiologists and clinicians in radiological clinical practice and enhance diagnostic accuracy and efficiency. However, the conventional systems primarily focus on delivering…
Developing safe, effective, and practically useful clinical prediction models (CPMs) traditionally requires iterative collaboration between clinical experts, data scientists, and informaticists. This process refines the often small but…
Artificial intelligence and medicine have a longstanding and proficuous relationship. In the present work we develop a brief assessment of this relationship with specific focus on machine learning, in which we highlight some critical points…
The emergence of digital pathology has opened new horizons for histopathology and cytology. Artificial-intelligence algorithms are able to operate on digitized slides to assist pathologists with diagnostic tasks. Whereas machine learning…
AI for cancer detection encounters the bottleneck of data scarcity, annotation difficulty, and low prevalence of early tumors. Tumor synthesis seeks to create artificial tumors in medical images, which can greatly diversify the data and…
As an important application of spatial databases in pathology imaging analysis, cross-comparing the spatial boundaries of a huge amount of segmented micro-anatomic objects demands extremely data- and compute-intensive operations, requiring…
The rapidly evolving field of digital oncopathology faces significant challenges, including the need to address diverse and complex clinical questions, often involving rare conditions, with limited availability of labeled data. These…
Radiology reporting generative AI holds significant potential to alleviate clinical workloads and streamline medical care. However, achieving high clinical accuracy is challenging, as radiological images often feature subtle lesions and…