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This work presents a framework for modeling three-dimensional scaffold-mediated bone regeneration and the associated optimization problem. By incorporating microstructure into the model through periodic homogenization, we capture the…
Bone healing process includes four phases: inflammatory response, soft callus formation, hard callus development, and remodeling. Mechanobiological models have been used to investigate the role of various mechanical and biological factors…
Osteoclastic resorption of bone plays a central role in both osteoporosis and bone metastasis. A reliable in vitro assay that simulates osteoclastic resorption in vivo would significantly speed up the process of devel-oping effective…
Osteoporosis silently erodes skeletal integrity worldwide; however, early detection through imaging can prevent most fragility fractures. Artificial intelligence (AI) methods now mine routine Dual-energy X-ray Absorptiometry (DXA), X-ray,…
Recurrence plot based methods are highly efficient and widely accepted tools for the investigation of time series or one-dimensional data. We present an extension of the recurrence plots and their quantifications in order to study recurrent…
The outcome of vertebroplasty is hard to predict due to its dependence on complex factors like bone cement and marrow rheologies. Cement leakage could occur if the procedure is done incorrectly, potentially causing adverse complications. A…
Bone is a multiscale heterogeneous materiel of which principal function is to support the body structure and to resist mechanical loading and fractures. Bone strength does not depend only on the quantity and quality of bone which is…
The aim of this paper is to develop a multiscale hierarchical hybrid model based on finite element analysis and neural network computation to link mesoscopic scale (trabecular network level) and macroscopic (whole bone level) to simulate…
Shear stress, hormones like parathyroid and mineral elements like calcium mediate the amplitude of stimulus signal which affects the rate of bone remodeling. The current study investigates the theoretical effects of different metabolic…
Long-term bone healing/adaptation after a dental implant treatment starts with diffusion of mesenchymal stem cells to the fracture callus and their subsequent differentiation. The healing phase is followed by the bone-remodeling phase. In…
Osteoporosis is a skeletal disorder that leads to increased fracture risk due to decreased strength of cortical and trabecular bone. Even with state-of-the-art non-invasive assessment methods there is still a high underdiagnosis rate.…
Osteolytic metastases located in the vertebrae reduce strength and enhance the risk of vertebral fractures. This risk can be predicted by means of validated finite element models, but their reproducibility needs to be assessed. For that…
Osteoporosis is a common condition that increases fracture risk, especially in older adults. Early diagnosis is vital for preventing fractures, reducing treatment costs, and preserving mobility. However, healthcare providers face challenges…
Stochastic microstructure reconstruction involves digital generation of microstructures that match key statistics and characteristics of a (set of) target microstructure(s). This process enables computational analyses on ensembles of…
We analyze the effect of tumor repopulation on optimal dose delivery in radiation therapy. We are primarily motivated by accelerated tumor repopulation towards the end of radiation treatment, which is believed to play a role in treatment…
We consider a simple one-dimensional time-dependent model for bone regeneration in the presence of a bio-resorbable polymer scaffold. Within the framework of the model, we optimize the effective mechanical stiffness of the polymer scaffold…
Computational modeling of the structural behavior of continuous fiber composite materials often takes into account the periodicity of the underlying micro-structure. A well established method dealing with the structural behavior of periodic…
Neurological injuries and age-related decline can impair sensory processing and disrupt motor coordination, gait, and balance. As mechanisms of neuroplasticity have become better understood, vibration-based interventions have gained…
Bone fragility and fracture caused by osteoporosis or injury are prevalent in adults over the age of 50 and can reduce their quality of life. Hence, predicting the biomechanical bone strength, specifically of the proximal femur, through…
Natural hard composites like human bone possess a combination of strength and toughness that exceeds that of their constituents and of many engineered composites. This augmentation is attributed to their complex hierarchical structure,…