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Neural networks have become dominant computational workloads across cloud and edge platforms, but their rapid growth in model size and deployment diversity has exposed hardware bottlenecks increasingly dominated by memory movement,…

Systems and Control · Electrical Eng. & Systems 2026-01-16 Bin Xu , Ayan Banerjee , Sandeep Gupta

Molecular dynamics (MD) simulations are widely used to study large-scale molecular systems. HPC systems are ideal platforms to run these studies, however, reaching the necessary simulation timescale to detect rare processes is challenging,…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-08-22 Tu Mai Anh Do , Loïc Pottier , Rafael Ferreira da Silva , Frédéric Suter , Silvina Caíno-Lores , Michela Taufer , Ewa Deelman

Neuroscientists apply a range of common analysis tools to recorded neural activity in order to glean insights into how neural circuits implement computations. Despite the fact that these tools shape the progress of the field as a whole, we…

Neurons and Cognition · Quantitative Biology 2022-02-16 Grace W. Lindsay

Neuromorphic Systems-on-Chip (NSoCs) are becoming heterogeneous by integrating general-purpose processors (GPPs) and neural processing units (NPUs) on the same SoC. For embedded systems, an NSoC may need to execute user applications built…

Hardware Architecture · Computer Science 2022-09-30 Anup Das

We present a framework that utilizes quantum algorithms, an architecture aware quantum noise model and an ideal simulator to benchmark quantum computers. The benchmark metrics highlight the difference between the quantum computer evolution…

Quantum Physics · Physics 2021-12-20 Konstantinos Georgopoulos , Clive Emary , Paolo Zuliani

The server central processing unit (CPU) market continues to exhibit robust demand due to the rising global need for computing power. Against this backdrop, CPU benchmark performance prediction is crucial for architecture designers. It…

Performance · Computer Science 2024-10-29 Xiaoman Liu

Medical language models must be updated as evidence and terminology evolve, yet sequential updating can trigger catastrophic forgetting. Although biomedical NLP has many static benchmarks, no unified, task-diverse benchmark exists for…

Artificial Intelligence · Computer Science 2026-03-18 Min Zeng , Shuang Zhou , Zaifu Zhan , Rui Zhang

Benchmarking is generally accepted as an important element in demonstrating the correctness of computer simulations. In the modern sense, a benchmark is a computer simulation result that has evidence of correctness, is accompanied by…

Plasma Physics · Physics 2015-06-12 M. M. Turner , A. Derzsi , Z. Donko , D. Eremin , S. J. Kelly , T. Lafleur , T. Mussenbrock

Large language models (LLMs) perform well on step-by-step reasoning benchmarks such as mathematics and code generation, yet their ability to carry out robust long-horizon planning under realistic constraints remains insufficiently…

Artificial Intelligence · Computer Science 2026-04-21 Petr Anokhin , Roman Khalikov , Stefan Rebrikov , Viktor Volkov , Artyom Sorokin , Vincent Bissonnette

The human brain has inspired novel concepts complementary to classical and quantum computing architectures, such as artificial neural networks and neuromorphic computers, but it is not clear how their performances compare. Here we report a…

Neurons and Cognition · Quantitative Biology 2023-05-25 Céline van Valkenhoef , Catherine Schuman , Philip Walther

Accurately assessing mental workload is crucial in cognitive neuroscience, human-computer interaction, and real-time monitoring, as cognitive load fluctuations affect performance and decision-making. While Electroencephalography (EEG) based…

Neural and Evolutionary Computing · Computer Science 2025-09-29 Jiahui An , Sara Irina Fabrikant , Giacomo Indiveri , Elisa Donati

Biometric systems based on brain activity have been proposed as an alternative to passwords or to complement current authentication techniques. By leveraging the unique brainwave patterns of individuals, these systems offer the possibility…

Cryptography and Security · Computer Science 2024-07-12 Avinash Kumar Chaurasia , Matin Fallahi , Thorsten Strufe , Philipp Terhörst , Patricia Arias Cabarcos

Advances in sequencing techniques have led to exponential growth in biological data, demanding the development of large-scale bioinformatics experiments. Because these experiments are computation- and data-intensive, they require…

Modern HPC systems are built with innovative system architectures and novel programming models to further push the speed limit of computing. The increased complexity poses challenges for performance portability and performance evaluation.…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-03-29 Holger Brunst , Sunita Chandrasekaran , Florina Ciorba , Nick Hagerty , Robert Henschel , Guido Juckeland , Junjie Li , Veronica G. Melesse Vergara , Sandra Wienke , Miguel Zavala

Multiscale simulations are essential in the biomedical domain to accurately model human physiology. We present a modular approach for designing, constructing and executing multiscale simulations on a wide range of resources, from desktops…

The unknown parameters of simulation models often need to be calibrated using observed data. When simulation models are expensive, calibration is usually carried out with an emulator. The effectiveness of the calibration process can be…

Computation · Statistics 2024-12-03 Özge Sürer , Stefan M. Wild

The NEURON simulator has been developed over the past three decades and is widely used by neuroscientists to model the electrical activity of neuronal networks. Large network simulation projects using NEURON have supercomputer allocations…

Neurons and Cognition · Quantitative Biology 2019-01-31 Pramod Kumbhar , Michael Hines , Jeremy Fouriaux , Aleksandr Ovcharenko , James King , Fabien Delalondre , Felix Schürmann

The Genomic Foundation Model (GFM) paradigm is expected to facilitate the extraction of generalizable representations from massive genomic data, thereby enabling their application across a spectrum of downstream applications. Despite…

Genomics · Quantitative Biology 2024-06-06 Zicheng Liu , Jiahui Li , Siyuan Li , Zelin Zang , Cheng Tan , Yufei Huang , Yajing Bai , Stan Z. Li

AI workloads, particularly those driven by deep learning, are introducing novel usage patterns to high-performance computing (HPC) systems that are not comprehensively captured by standard HPC benchmarks. As one of the largest academic…

Modern high performance computing (HPC) systems exhibit a rapid growth in size, both "horizontally" in the number of nodes, as well as "vertically" in the number of cores per node. As such, they offer additional levels of hardware…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-11-06 Ahmed Eleliemy , Ali Mohammed , Florina M. Ciorba