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Disease-gene prediction (DGP) refers to the computational challenge of predicting associations between genes and diseases. Effective solutions to the DGP problem have the potential to accelerate the therapeutic development pipeline at early…

Machine Learning · Computer Science 2019-07-15 Vikash Singh , Pietro Lio'

In this paper we introduce a model of lifelong learning, based on a Network of Experts. New tasks / experts are learned and added to the model sequentially, building on what was learned before. To ensure scalability of this process,data…

Computer Vision and Pattern Recognition · Computer Science 2017-04-20 Rahaf Aljundi , Punarjay Chakravarty , Tinne Tuytelaars

Developments in deep generative models have allowed for tractable learning of high-dimensional data distributions. While the employed learning procedures typically assume that training data is drawn i.i.d. from the distribution of interest,…

Machine Learning · Computer Science 2017-05-24 Ari Seff , Alex Beatson , Daniel Suo , Han Liu

Deep generative models are commonly used for generating images and text. Interpretability of these models is one important pursuit, other than the generation quality. Variational auto-encoder (VAE) with Gaussian distribution as prior has…

Machine Learning · Computer Science 2020-08-24 Wenxian Shi , Hao Zhou , Ning Miao , Lei Li

The deployment of large language models (LLMs) like ChatGPT and Gemini has shown their powerful natural language generation capabilities. However, these models can inadvertently learn and retain sensitive information and harmful content…

Cryptography and Security · Computer Science 2025-10-14 Shang Wang , Tianqing Zhu , Dayong Ye , Wanlei Zhou

Diffusion models have established themselves as state-of-the-art generative models across various data modalities, including images and videos, due to their ability to accurately approximate complex data distributions. Unlike traditional…

Machine Learning · Computer Science 2025-10-23 Daniel Wesego

Variational Autoencoder (VAE)-based generative models offer flexible representation learning by incorporating meta-priors, general premises considered beneficial for downstream tasks. However, the incorporated meta-priors often involve…

Machine Learning · Computer Science 2023-02-27 Nao Nakagawa , Ren Togo , Takahiro Ogawa , Miki Haseyama

While Variational Inference (VI) is central to modern generative models like Variational Autoencoders (VAEs) and Denoising Diffusion Models (DDMs), its pedagogical treatment is split across disciplines. In statistics, VI is typically framed…

Machine Learning · Statistics 2025-10-22 Yen-Chi Chen

Modelling the underlying mechanisms of neurodegenerative diseases demands methods that capture heterogeneous and spatially varying dynamics from sparse, high-dimensional neuroimaging data. Integrating partial differential equation (PDE)…

Image and Video Processing · Electrical Eng. & Systems 2025-09-19 Sanduni Pinnawala , Annabelle Hartanto , Ivor J. A. Simpson , Peter A. Wijeratne

Probabilistic graphical modeling (PGM) provides a framework for formulating an interpretable generative process of data and expressing uncertainty about unknowns, but it lacks flexibility. Deep learning (DL) is an alternative framework for…

Machine Learning · Statistics 2021-04-27 Adji B. Dieng

Continually adapting edge models in cloud-edge collaborative object detection for traffic monitoring suffers from catastrophic forgetting, where models lose previously learned knowledge when adapting to new data distributions. This is…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Xinrun Xu , Jianwen Yang , Qiuhong Zhang , Zhanbiao Lian , Zhiming Ding , Shan Jiang

Variational AutoEncoders (VAEs) are powerful generative models that merge elements from statistics and information theory with the flexibility offered by deep neural networks to efficiently solve the generation problem for high dimensional…

Machine Learning · Computer Science 2021-03-02 A. Asperti , D. Evangelista , E. Loli Piccolomini

Large language models (LLMs) often struggle with knowledge-intensive tasks due to hallucinations and outdated parametric knowledge. While Retrieval-Augmented Generation (RAG) addresses this by integrating external corpora, its effectiveness…

Computation and Language · Computer Science 2026-02-04 Su Dong , Qinggang Zhang , Yilin Xiao , Shengyuan Chen , Chuang Zhou , Xiao Huang

Recently, generative graph models have shown promising results in learning graph representations through self-supervised methods. However, most existing generative graph representation learning (GRL) approaches rely on random masking across…

Machine Learning · Computer Science 2026-05-08 Xinyue Hu , Zhibin Duan , Xinyang Liu , Yuxin Li , Bo Chen , Chaojie Wang , Yilin He , Hongwei Liu , Mingyuan Zhou

From childhood to youth, human gradually come to know the world. But for neural networks, this growing process seems difficult. Trapped in catastrophic forgetting, current researchers feed data of all categories to a neural network which…

Machine Learning · Computer Science 2020-04-28 Youcheng Huang , Tangchen Wei , Jundong Zhou , Chunxin Yang

Building learning agents that can progressively learn and accumulate knowledge is the core goal of the continual learning (CL) research field. Unfortunately, training a model on new data usually compromises the performance on past data. In…

Machine Learning · Computer Science 2023-05-17 Timothée Lesort , Oleksiy Ostapenko , Diganta Misra , Md Rifat Arefin , Pau Rodríguez , Laurent Charlin , Irina Rish

Many real-world problems require reasoning across multiple scales, demanding models which operate not on single data points, but on entire distributions. We introduce generative distribution embeddings (GDE), a framework that lifts…

Machine Learning · Computer Science 2026-02-23 Nic Fishman , Gokul Gowri , Peng Yin , Jonathan Gootenberg , Omar Abudayyeh

Attempts to train a comprehensive artificial intelligence capable of solving multiple tasks have been impeded by a chronic problem called catastrophic forgetting. Although simply replaying all previous data alleviates the problem, it…

Artificial Intelligence · Computer Science 2017-12-13 Hanul Shin , Jung Kwon Lee , Jaehong Kim , Jiwon Kim

Entity alignment (EA) for knowledge graphs (KGs) plays a critical role in knowledge engineering. Existing EA methods mostly focus on utilizing the graph structures and entity attributes (including literals), but ignore images that are…

Artificial Intelligence · Computer Science 2023-03-14 Yangning Li , Jiaoyan Chen , Yinghui Li , Yuejia Xiang , Xi Chen , Hai-Tao Zheng

When handling streaming graphs, existing graph representation learning models encounter a catastrophic forgetting problem, where previously learned knowledge of these models is easily overwritten when learning with newly incoming graphs. In…

Machine Learning · Computer Science 2024-07-11 Yilun Liu , Ruihong Qiu , Yanran Tang , Hongzhi Yin , Zi Huang
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