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Molecular docking is a critical process for drug discovery and challenging due to the complexity and size of biomolecular systems, where the optimal binding configuration of a drug to a target protein is determined. Hybrid classical-quantum…

Emerging Technologies · Computer Science 2025-03-07 Christos Papalitsas , Yanfei Guan , Shreyas Waghe , Athanasios Liakos , Ioannis Balatsos , Vassilios Pantazopoulos

We introduce a digital-analog quantum computing framework that enables counterdiabatic protocols to be implemented at constant circuit depth, allowing fast and resource-efficient quantum state preparation on current quantum hardware.…

Recent work [1] has claimed that a gate-model quantum-classical hybrid algorithm called bias-field digitized counterdiabatic quantum optimization (BF-DCQO) [2] outperforms D-Wave's annealing quantum computers in optimization tasks. We find…

Quantum Physics · Physics 2025-09-19 Pau Farré , Erika Ordog , Kevin Chern , Catherine C. McGeoch

In this paper we show how to implement in a simple way some complex real-life constraints on the portfolio optimization problem, so that it becomes amenable to quantum optimization algorithms. Specifically, first we explain how to obtain…

Portfolio Management · Quantitative Finance 2021-08-23 Samuel Palmer , Serkan Sahin , Rodrigo Hernandez , Samuel Mugel , Roman Orus

Quantum algorithms have gained increasing attention for addressing complex combinatorial problems in finance, notably portfolio optimization. This study systematically benchmarks two prominent variational quantum approaches, Variational…

Quantum Physics · Physics 2025-12-05 Nouhaila Innan , Ayesha Saleem , Alberto Marchisio , Muhammad Shafique

Quantum computing is poised to transform the financial industry, yet its advantages over traditional methods have not been evidenced. As this technology rapidly evolves, benchmarking is essential to fairly evaluate and compare different…

Optimization and Control · Mathematics 2025-02-11 Ying Chen , Thorsten Koch , Hanqiu Peng , Hongrui Zhang

The quantum approximate optimisation algorithm was proposed as a heuristic method for solving combinatorial optimisation problems on near-term quantum computers and may be among the first algorithms to perform useful computations in the…

Quantum Physics · Physics 2022-11-10 David Headley , Thorge Müller , Ana Martin , Enrique Solano , Mikel Sanz , Frank K. Wilhelm

In this note, we describe an experiment on portfolio optimization using the Quadratic Unconstrained Binary Optimization (QUBO) formulation. The dataset we use is taken from a real-world problem for which a classical solution is currently…

Adiabatic quantum computing (AQC) started as an approach to solving optimization problems, and has evolved into an important universal alternative to the standard circuit model of quantum computing, with deep connections to both classical…

Quantum Physics · Physics 2018-02-05 Tameem Albash , Daniel A. Lidar

Adiabatic quantum computing is a universal model for quantum computing whose implementation using a gate-based quantum computer requires depths that are unreachable in the early fault-tolerant era. To mitigate the limitations of near-term…

Quantum Physics · Physics 2024-10-18 Ioannis Kolotouros , Ioannis Petrongonas , Miloš Prokop , Petros Wallden

We describe tensor network algorithms to optimize quantum circuits for adiabatic quantum computing. To suppress diabatic transitions, we include counterdiabatic driving in the optimization and utilize variational matrix product operators to…

Quantum Physics · Physics 2024-06-21 Conor Mc Keever , Michael Lubasch

Counterdiabatic driving emerges as a valuable technique for implementing shortcuts to adiabaticity protocols, enhancing quantum technology applications. In this context, counterdiabatic quantum computing represents a new paradigm with the…

In this paper we tackle the problem of dynamic portfolio optimization, i.e., determining the optimal trading trajectory for an investment portfolio of assets over a period of time, taking into account transaction costs and other possible…

Portfolio construction has been a long-standing topic of research in finance. The computational complexity and the time taken both increase rapidly with the number of investments in the portfolio. It becomes difficult, even impossible for…

Computational Engineering, Finance, and Science · Computer Science 2024-10-17 Queenie Sun , Nicholas Grablevsky , Huaizhang Deng , Pooya Azadi

We present a quantum algorithm for portfolio optimisation. Specifically, We present an end-to-end quantum approximate optimisation algorithm (QAOA) to solve the discrete global minimum variance portfolio (DGMVP) model. This model finds a…

Quantum Physics · Physics 2024-10-22 Haomu Yuan , Christopher K. Long , Hugo V. Lepage , Crispin H. W. Barnes

Adiabatic quantum computing (AQC) is a promising approach for discrete and often NP-hard optimization problems. Current AQCs allow to implement problems of research interest, which has sparked the development of quantum representations for…

Machine Learning · Computer Science 2024-05-02 Jan-Nico Zaech , Martin Danelljan , Tolga Birdal , Luc Van Gool

Portfolio optimization is a cornerstone of financial decision-making, traditionally relying on classical algorithms to balance risk and return. Recent advances in quantum computing offer a promising alternative, leveraging quantum…

Quantum Physics · Physics 2025-11-27 Vicente P. Soloviev , Michal Krompiec

Previously only considered a frontier area of Physics, nowadays quantum computing is one of the fastest growing research field, precisely because of its technological applications in optimization problems, machine learning, information…

Portfolio Management · Quantitative Finance 2022-08-24 Askery Canabarro , Taysa M. Mendonça , Ranieri Nery , George Moreno , Anton S. Albino , Gleydson F. de Jesus , Rafael Chaves

Quantum algorithms are prominent in the pursuit of achieving quantum advantage in various computational tasks. However, addressing challenges, such as limited qubit coherence and high error rate in near-term devices, requires extensive…

Quantum Physics · Physics 2024-07-31 Julián Ferreiro-Vélez , Iñaki Iriarte-Zendoia , Yue Ban , Xi Chen

Quantum Machine Learning (QML) shows how it maintains certain significant advantages over machine learning methods. It now shows that hybrid quantum methods have great scope for deployment and optimisation, and hold promise for future…

Machine Learning · Computer Science 2023-01-03 Juan Kenyhy Hancco-Quispe , Jordan Piero Borda-Colque , Fred Torres-Cruz