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An epidemic carries human and fiscal costs. In the case of imported pandemics, the first-best solution is to restrict national borders to identify and isolate infected individuals. However, when that opportunity is not fully seized and…

Populations and Evolution · Quantitative Biology 2022-03-31 Mayteé Cruz-Aponte , José Caraballo-Cueto

The aim of this paper is twofold. On one hand, we strive to give a simpler proof of the optimality of greedy controls when the cost of interventions is control-affine and the dynamics follow a state-constrained controlled SIR model. This is…

Optimization and Control · Mathematics 2022-05-19 Lorenzo Freddi , Dan Goreac , Juan Li , Boxiang Xu

The COVID-19 pandemic due to the SARS-CoV-2 coronavirus has directly impacted the public health and economy worldwide. To overcome this problem, countries have adopted different policies and non-pharmaceutical interventions for controlling…

We model further development of the COVID-19 epidemic in the UK given the current data and assuming different scenarios of handling the epidemic. In this research, we further extend the stochastic model suggested in \cite{us} and…

Populations and Evolution · Quantitative Biology 2020-04-10 Anatoly Zhigljavsky , Roger Whitaker , Ivan Fesenko , Kobi Kremnizer , Jack Noonan

Game theory has been an effective tool in the control of disease spread and in suggesting optimal policies at both individual and area levels. In this paper, we propose a multi-region SEIR model based on stochastic differential game theory,…

Optimization and Control · Mathematics 2021-03-10 Yao Xuan , Robert Balkin , Jiequn Han , Ruimeng Hu , Hector D. Ceniceros

We present a data-driven optimal control approach which integrates the reported partial data with the epidemic dynamics for COVID-19. We use a basic Susceptible-Exposed-Infectious-Recovered (SEIR) model, the model parameters are…

Optimization and Control · Mathematics 2020-12-22 Hailiang Liu , Xuping Tian

SIR models, also with age structure, can be used to describe the evolution of an infective disease. A vaccination campaign influences this dynamics immunizing part of the susceptible individuals, essentially turning them into recovered…

Analysis of PDEs · Mathematics 2019-10-17 Rinaldo M. Colombo , Mauro Garavello

Social distancing has been the only effective way to contain the spread of an infectious disease prior to the availability of the pharmaceutical treatment. It can lower the infection rate of the disease at the economic cost. A pandemic…

Applications · Statistics 2020-12-07 Kexin Chen , Chi Seng Pun , Hoi Ying Wong

This paper is concerned with the well-posedness and optimal control problem of a reaction-diffusion system for an epidemic Susceptible-Infected-Recovered-Susceptible (SIRS) mathematical model in which the dynamics develops in a spatially…

Optimization and Control · Mathematics 2023-04-24 Pierluigi Colli , Gianni Gilardi , Gabriela Marinoschi , Elisabetta Rocca

The current global health emergency triggered by the pandemic COVID-19 is one of the greatest challenges mankind face in this generation. Computational simulations have played an important role to predict the development of the current…

Populations and Evolution · Quantitative Biology 2020-06-11 Kok Yew Ng , Meei Mei Gui

Cost-effectiveness analysis is a mode of determining both the cost and economic health outcomes of one or more control interventions. In this work, we have formulated a non-autonomous nonlinear deterministic model to study the control of…

Motivated by the issue of COVID-19 mitigation, in this work we tackle the general problem of optimally controlling an epidemic outbreak of a communicable disease structured by time since exposure, by the aid of two types of control…

Populations and Evolution · Quantitative Biology 2024-05-13 Alberto d'Onofrio , Mimmo Iannelli , Piero Manfredi , Gabriela Marinoschi

On 19th March, the World Health Organisation declared a pandemic. Through this global spread, many nations have witnessed exponential growth of confirmed cases brought under control by severe mass quarantine or lockdown measures. However,…

Other Quantitative Biology · Quantitative Biology 2022-09-28 Annalisa Riccardi , Jessica Gemignani , Francisco Fernández-Navarro , Anna Heffernan

We propose a stochastic SIR model, specified as a system of stochastic differential equations, to analyse the data of the Italian COVID-19 epidemic, taking also into account the under-detection of infected and recovered individuals in the…

Populations and Evolution · Quantitative Biology 2021-02-22 Sara Pasquali , Antonio Pievatolo , Antonella Bodini , Fabrizio Ruggeri

A crucial aspect of managing a public health crisis is to effectively balance prevention and mitigation strategies, while taking their socio-economic impact into account. In particular, determining the influence of different…

This study assesses the impact of COVID-19 vaccines through an epidemiological model that quantifies their role in pandemic control. We analyze an SIR-based model incorporating vaccination effects and calculate the basic reproduction…

Dynamical Systems · Mathematics 2025-07-29 Tesfalem Abate Tegegn , Yibeltal Adane Terefe

The coronavirus disease 2019 (COVID-19) global pandemic has led many countries to impose unprecedented lockdown measures in order to slow down the outbreak. Questions on whether governments have acted promptly enough, and whether lockdown…

Applications · Statistics 2020-06-04 Zhaozhi Qian , Ahmed M. Alaa , Mihaela van der Schaar

A mathematical model was developed describing the dynamic of the COVID-19 virus over a population considering that the infected can either be symptomatic or not. The model was calibrated using data on the confirmed cases and death from…

Populations and Evolution · Quantitative Biology 2020-04-14 Jayrold P. Arcede , Randy L. Caga-anan , Cheryl Q. Mentuda , Youcef Mammeri

This document aims to estimate and describe the effects of the social distancing measures implemented in several countries with the expectancy of controlling the spread of COVID-19. The procedure relies on the classic…

Populations and Evolution · Quantitative Biology 2021-06-28 Gerardo L. Febres

Non-pharmaceutical interventions(NPIs) play an important role in the early stage control of COVID-19 pandemic. Vaccination is considered to be the inevitable course to stop the spread of SARS-CoV-2. Based on the mechanism, a SVEIR COVID-19…

Populations and Evolution · Quantitative Biology 2021-07-08 Bin-Guo Wang , Shunxiang Huang , Yongping Xiong , Ming-Zhen Xin , Jing LI , Jiangqian Zhang , Zhihui Ma
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