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Electrochemical quartz crystal microbalance (EC-QCM) is a versatile gravimetric technique that allows for parallel characterization of mass deposition and electrochemical properties. Despite its broad applicability, simultaneous…

Decentralized diagnostic testing that is accurate, portable, quantitative, and capable of making multiple simultaneous measurements of different biomarkers at the point-of-need remains an important unmet need in the post-pandemic world.…

We have developed a contact-less technique for the real time measurement of a-thermal (Cooper-pair breaking) phonons in an absorber held at sub-Kelvin temperatures. In particular, a thin-film aluminum superconducting resonator was realized…

Whispering gallery mode (WGM) microcavities feature ultrahigh Q-factors and small mode volumes, offering strong light-matter interactions for sensing applications. However, unmodified surfaces are weakly responsive togas-phase refractive…

Surface electromyography (sEMG) is a noninvasive technique widely used to control myoelectric prostheses and other human-machine interfaces. However, the high cost of commercial systems limits accessibility in academic and research…

Numerous molecules exhibit unique absorption bands in the fingerprint infrared (IR) region, allowing chemical identification and detection. This makes IR spectroscopy an essential tool in biomedical diagnostics, sensing, and material…

Optics · Physics 2022-02-04 Anna V. Paterova , Zi S. D. Toa , Hongzhi Yang , Leonid A. Krivitsky

The ability to detect and identify molecules at high sensitivity without the use of labels or capture agents is important for medical diagnostics, threat identification, environmental monitoring, and basic science. Microtoroid optical…

Optics · Physics 2022-10-17 Gwangho Choi , Adley Gin , Judith Su

We study the use of atom interferometers as detectors for gravitational waves in the mHz - Hz frequency band, which is complementary to planned optical interferometers, such as laser interferometer gravitational wave observatories (LIGOs)…

General Relativity and Quantum Cosmology · Physics 2011-06-02 Michael Hohensee , Shau-Yu Lan , Rachel Houtz , Cheong Chan , Brian Estey , Geena Kim , Pei-Chen Kuan , Holger Mueller

Surface electromyography (sEMG) is a popular bio-signal used for controlling prostheses and finger gesture recognition mechanisms. Myoelectric prostheses are costly, and most commercially available sEMG acquisition systems are not suitable…

We report the modification of a label-free image scanning microscope (ISM) to perform asynchronous 2D imaging at 24kHz while keeping the lateral resolution gain and background rejection of a regular label-free ISM setup. Our method uses a…

Optics · Physics 2023-08-31 Duc-Minh Ta , Alberto Aguilar , Pierre Bon

Compact inductor-capacitor (LC) resonators, in contrast to coplanar waveguide (CPW) resonators, have a simple lumped-element circuit representation but usually call for sophisticated finite-element method (FEM) simulations for an accurate…

Designing terahertz sensors with high sensitivity to detect nanoscale thin films and single biomolecule presents a significant challenge, and addressing these obstacles is crucial for unlocking their full potential in scientific research…

We present a prism-coupled packaging strategy for whispering-gallery mode resonators (WGMRs). Utilizing an all-solid-state optical adhesive process with active temperature control and hermetic sealing, the package exhibits exceptional…

Optics · Physics 2025-10-14 Jiajun Wu , Xuanqi Wang , Chengyu Zhang , Chenghong Li , Shan Zhong , Songbai Kang

The principles of quantum optics have yielded a plethora of ideas to surpass the classical limitations of sensitivity and resolution in optical microscopy. While some ideas have been applied in proof-of-principle experiments, imaging a…

We report progress toward a CMOS-integrated quantum diamond biosensing platform that combines nitrogen-vacancy (NV) centers in diamond with a custom 40 nm CMOS Single-Photon Avalanche Diode (SPAD) array. The system integrates on-chip active…

Silicon nanochannel field effect transistor (FET) biosensors are one of the most promising technologies in the development of highly sensitive and label-free analyte detection for cancer diagnostics. With their exceptional electrical…

Quantitative Methods · Quantitative Biology 2014-01-07 Pritiraj Mohanty , Yu Chen , Xihua Wang , Mi K. Hong , Carol L. Rosenberg , David T. Weaver , Shyamsunder Erramilli

Continuous ambulatory monitoring of peripheral vascular perfusion could enable earlier detection of vascular dysfunction in individuals with diabetes mellitus and more timely management of cardiovascular disease. Clinical imaging modalities…

In quantum logic spectroscopy (QLS), one species of trapped ion is used as a sensor to detect the state of an otherwise inaccessible ion species. This extends precision measurements to a broader class of atomic and molecular systems for…

Atomic Physics · Physics 2022-11-16 Kaifeng Cui , Jose Valencia , Kevin T. Boyce , David R. Leibrandt , David B. Hume

Superconducting resonators with high quality factors are extremely sensitive detectors of the complex impedance of materials and devices coupled to them. This capability has been used to measure losses in multiple different materials and,…

Quantum Physics · Physics 2025-07-01 Jared Gibson , Zhanzhi Jiang , Angela Kou

Magnetic resonance spectroscopy is universally regarded as one of the most important tools in chemical and bio-medical research. However, sensitivity limitations typically restrict imaging resolution to length scales greater than 10 \mu m.…

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