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Label-free biosensors, including conventional quartz-crystal-microbalance (QCM) biosensor, are seriously affected by nonspecific adsorption of contaminants involved in analyte solution, and it is exceptionally difficult to extract the…

Biological Physics · Physics 2021-12-15 Kentaro Noi , Arihiro Iwata , Fumihito Kato , Hirotsugu Ogi

This paper proposes a novel wireless, battery-free, and label-free biosensor for minimally invasive and non-invasive permittivity sensing for applications such as detecting glucose levels in the interstitial dermal fluid. The miniaturized,…

Applied Physics · Physics 2022-10-19 Rehab S. Hassan

Magnetic sensing is present in our everyday interactions with consumer electronics, and also demonstrates potential for measurement of extremely weak biomagnetic fields, such as those of the heart and brain. In this work, we leverage the…

Applied Physics · Physics 2019-11-26 Josh Javor , Alexander Stange , Corey Pollock , Nicholas Fuhr , David J. Bishop

Whispering gallery mode (WGM) laser sensors, utilizing the interaction between the in-plane evanescent field and the surface vicinity, provide enhanced sensitivity in label-free sensing for bioanalysis and disease screening. However, the…

Optics · Physics 2025-08-25 Xiaolu Cui , Jiyang Ma , Hao Wu , Shuoying Zhao , Xubiao Peng , Chuyu Li , Ruiqi Ming , Qing Zhao

We have demonstrated atomically thin, quantum capacitance-limited, field-effect transistors (FETs) that enable the detection of pH changes with ~75-fold higher sensitivity (4.4 V/pH) over the Nernst value of 59 mV/pH at room temperature…

Traditional detection methods of C-reactive protein (CRP) inflammation biomarker, in blood are expensive, time-consuming and labor-intensive. Such existing point-of-care CRP detection devices remain invasive, since they need blood sampling…

Medical Physics · Physics 2024-07-25 Aristea Grammoustianou , Ali Saeidi , Johan Longo , Felix Risch , Adrian M. Ionescu

Optical metasurface has brought a revolution in label-free molecular sensing, attracting extensive attention. Currently, such sensing approaches are being designed to respond to peak wavelengths with a higher Q factor in the visible and…

The measurement of the biological tissue's electrical impedance is an active research field that has attracted a lot of attention during the last decades. Bio-impedances are closely related to a large variety of physiological conditions;…

Emerging Technologies · Computer Science 2015-07-14 Saul Rodriguez , Stig Ollmar , Muhammad Waqar , Ana Rusu

We numerically design a hybrid plasmonic dielectric refractive index biosensor comprising ametal insulator metal (MIM) bus waveguide evanescently coupled to a silicon core resonator. The geometry is optimized with a genetic algorithm (GA)…

Instrumentation and Detectors · Physics 2025-08-27 Alireza Khalilian , Hima Nikafshan Rad

In this letter, we propose a dielectric-modulated Impact-Ionization MOS (DIMOS) transistor based sensor for application in label-free detection of biomolecules. Numerous reports exist on the experimental demonstration of nanogap-embedded…

Mesoscale and Nanoscale Physics · Physics 2014-03-28 N. Kannan , M. Jagadesh Kumar

There has been a recent tremendous interest in label-free detection of biomarkers which is a critical enabler of point-of-need diagnostics. A low-power, small form factor, multiplexed wearable system is proposed for continuous detection of…

Signal Processing · Electrical Eng. & Systems 2021-04-06 Devangsingh Sankhala , Madhavi Pali , Kai-Chun Lin , Badrinath Jagannath , Sriram Muthukumar , Shalini Prasad

Studies of biological solutions require high measurement accuracy, the ability to detect low changes in substance concentration, and small amounts of the liquid under test. A microwave complex permittivity measurement technique based on a…

The terahertz (THz) spectral regime offers unique opportunities for next-generation biochemical sensing due to its non-destructive, label-free probing capability and strong sensitivity to molecular vibrations. However, conventional THz…

Quantum biosensors offer a promising route to overcome the sensitivity and specificity limitations of conventional biosensing technologies. Their ability to detect biochemical signals at extremely low concentrations makes them strong…

Optics · Physics 2025-08-05 Yasaman Torabi , Shahram Shirani , James P. Reilly

This study focuses on developing a metal-dielectric sensor structure with optimized unit cell geometry for determination of protein Immunoglobulin G (IgG) concentration in aqueous solutions. The research combines both experimental and…

Optics · Physics 2026-01-12 K. S. Kuznetsova , V. A. Pashynska , Z. E. Eremenko

Biosensing based on whispering-gallery mode (WGM) resonators has been continuously studied with great attention due to its excellent sensitivity guaranteeing the label-free detection. However, its practical impact is insignificant to date…

Applied Physics · Physics 2020-01-08 Yeseul Kim , Hansuek Lee

This paper reports the first demonstration of a magnet-free, high performance microelectromechanical system (MEMS) based circulator. An innovative circuit based on the commutation of MEMS resonators with high quality (Q) factor using RF…

We propose a new label-free ultrasonic sensor, which comprises a slot wave-guide and double silicon-on-insulator (SOI) slot micro-ring resonators. The all-optical sensors do not suffer from electromagnetic interference. We choose to…

Optics · Physics 2022-04-04 Cheng Mei Zhang , Chao Ying Zhao

Bacterial infectious diseases are a major threat to human health. Timely and sensitive pathogenic bacteria detection is crucial in identifying the bacterial contaminations and preventing the spread of infectious diseases. Due to limitations…

Label-free biosensors are important tools for clinical diagnostics and for studying biology at the single molecule level. The development of optical label-free sensors has allowed extreme sensitivity, but can expose the biological sample to…

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