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Computational pathology (CPath) has significantly advanced the clinical practice of pathology. Despite the progress made, Multiple Instance Learning (MIL), a promising paradigm within CPath, continues to face challenges, particularly…

Computer Vision and Pattern Recognition · Computer Science 2024-08-28 Yuqi Zhang , Xiaoqian Zhang , Jiakai Wang , Yuancheng Yang , Taiying Peng , Chao Tong

Multimodal Fusion Learning (MFL), leveraging disparate data from various imaging modalities (e.g., MRI, CT, SPECT), has shown great potential for addressing medical problems such as skin cancer and brain tumor prediction. However, existing…

Computer Vision and Pattern Recognition · Computer Science 2026-02-18 Joy Dhar , Nayyar Zaidi , Maryam Haghighat

Multiple Instance Learning (MIL) for whole slide image (WSI) analysis in computational pathology often neglects instance-level learning as supervision is typically provided only at the bag level, hindering the integrated consideration of…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Shuyang Wu , Yifu Qiu , Ines P. Nearchou , Sandrine Prost , Jonathan A. Fallowfield , Hideki Ueno , Hitoshi Tsuda , David J. Harrison , Hakan Bilen , Timothy J. Kendall

Multiple Instance Learning (MIL), a powerful strategy for weakly supervised learning, is able to perform various prediction tasks on gigapixel Whole Slide Images (WSIs). However, the tens of thousands of patches in WSIs usually incur a vast…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Zhuchen Shao , Liuxi Dai , Yifeng Wang , Haoqian Wang , Yongbing Zhang

Multiple Instance Learning (MIL) recently provides an appealing way to alleviate the drifting problem in visual tracking. Following the tracking-by-detection framework, an online MILBoost approach is developed that sequentially chooses weak…

Computer Vision and Pattern Recognition · Computer Science 2020-03-18 Jinwu Liu , Yao Lu , Tianfei Zhou

The computer-aided analysis of medical scans is a longstanding goal in the medical imaging field. Currently, deep learning has became a dominant methodology for supporting pathologists and radiologist. Deep learning algorithms have been…

Machine Learning · Computer Science 2017-12-06 Jakub M. Tomczak , Maximilian Ilse , Max Welling

The first step in Multiple Instance Learning (MIL) algorithms for Whole Slide Image (WSI) classification consists of tiling the input image into smaller patches and computing their feature vectors produced by a pre-trained feature extractor…

Computer Vision and Pattern Recognition · Computer Science 2024-03-11 Juan I. Pisula , Katarzyna Bozek

In this work, we present a novel mask guided attention (MGA) method for fine-grained patchy image classification. The key challenge of fine-grained patchy image classification lies in two folds, ultra-fine-grained inter-category variances…

Computer Vision and Pattern Recognition · Computer Science 2021-09-23 Jun Wang , Xiaohan Yu , Yongsheng Gao

Model-based imitation learning (MBIL) is a popular reinforcement learning method that improves sample efficiency on high-dimension input sources, such as images and videos. Following the convention of MBIL research, existing algorithms are…

Machine Learning · Computer Science 2023-06-21 Shenghua Wan , Yucen Wang , Minghao Shao , Ruying Chen , De-Chuan Zhan

Multi-modal class-incremental learning (MMCIL) seeks to leverage multi-modal data, such as audio-visual and image-text pairs, thereby enabling models to learn continuously across a sequence of tasks while mitigating forgetting. While…

Machine Learning · Computer Science 2025-01-17 Xianghu Yue , Yiming Chen , Xueyi Zhang , Xiaoxue Gao , Mengling Feng , Mingrui Lao , Huiping Zhuang , Haizhou Li

Digital pathology based on whole slide images (WSIs) plays a key role in cancer diagnosis and clinical practice. Due to the high resolution of the WSI and the unavailability of patch-level annotations, WSI classification is usually…

Computer Vision and Pattern Recognition · Computer Science 2023-05-02 Litao Yang , Deval Mehta , Sidong Liu , Dwarikanath Mahapatra , Antonio Di Ieva , Zongyuan Ge

We introduce ReaMIL (Reasoning- and Evidence-Aware MIL), a multiple instance learning approach for whole-slide histopathology that adds a light selection head to a strong MIL backbone. The head produces soft per-tile gates and is trained…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Hyun Do Jung , Jungwon Choi , Hwiyoung Kim

Multiple Instance Learning (MIL) methods have become increasingly popular for classifying giga-pixel sized Whole-Slide Images (WSIs) in digital pathology. Most MIL methods operate at a single WSI magnification, by processing all the tissue…

Computer Vision and Pattern Recognition · Computer Science 2022-07-27 Kevin Thandiackal , Boqi Chen , Pushpak Pati , Guillaume Jaume , Drew F. K. Williamson , Maria Gabrani , Orcun Goksel

Histopathological whole slide image (WSI) analysis with deep learning has become a research focus in computational pathology. The current paradigm is mainly based on multiple instance learning (MIL), in which approaches with Transformer as…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Hongbo Chu , Qiehe Sun , Jiawen Li , Yuxuan Chen , Lizhong Zhang , Tian Guan , Anjia Han , Yonghong He

Lesion appearance is a crucial clue for medical providers to distinguish referable diabetic retinopathy (rDR) from non-referable DR. Most existing large-scale DR datasets contain only image-level labels rather than pixel-based annotations.…

Image and Video Processing · Electrical Eng. & Systems 2022-10-13 Wenhui Zhu , Peijie Qiu , Natasha Lepore , Oana M. Dumitrascu , Yalin Wang

Digital pathology has revolutionized the field by enabling the digitization of tissue samples into whole slide images (WSIs). However, the high resolution and large size of WSIs present significant challenges when it comes to applying Deep…

Computer Vision and Pattern Recognition · Computer Science 2025-07-03 Ali Mammadov , Loïc Le Folgoc , Guillaume Hocquet , Pietro Gori

With the memory-resource-limited constraints, class-incremental learning (CIL) usually suffers from the "catastrophic forgetting" problem when updating the joint classification model on the arrival of newly added classes. To cope with the…

Machine Learning · Computer Science 2021-05-19 Hanbin Zhao , Hui Wang , Yongjian Fu , Fei Wu , Xi Li

Multiple Instance Learning (MIL) is a popular weakly-supervised method for various applications, with a particular interest in histological whole slide image (WSI) classification. Due to the gigapixel resolution of WSI, applications of MIL…

Computer Vision and Pattern Recognition · Computer Science 2025-05-21 Wenhui Zhu , Peijie Qiu , Xiwen Chen , Zhangsihao Yang , Aristeidis Sotiras , Abolfazl Razi , Yalin Wang

Multiple Instance Learning (MIL) methods have succeeded remarkably in histopathology whole slide image (WSI) analysis. However, most MIL models only offer attention-based explanations that do not faithfully capture the model's decision…

Computer Vision and Pattern Recognition · Computer Science 2025-07-17 Susu Sun , Dominique van Midden , Geert Litjens , Christian F. Baumgartner

Multi-instance learning is common for computer vision tasks, especially in biomedical image processing. Traditional methods for multi-instance learning focus on designing feature aggregation methods and multi-instance classifiers, where the…

Computer Vision and Pattern Recognition · Computer Science 2021-03-18 Yanlun Tu , Houchao Lei , Wei Long , Yang Yang