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We consider integrative modeling of multiple gene networks and diverse genomic data, including protein-DNA binding, gene expression and DNA sequence data, to accurately identify the regulatory target genes of a transcription factor (TF).…

Applications · Statistics 2012-03-21 Peng Wei , Wei Pan

Modern cancer genomics datasets involve widely varying sizes and scales, measurement variables, and correlation structures. A fundamental analytical goal in these high-throughput studies is the development of general statistical techniques…

Methodology · Statistics 2022-04-12 Chiyu Gu , Veerabhadran Baladandayuthapani , Subharup Guha

This article introduces a nonparametric approach to multivariate time-varying power spectrum analysis. The procedure adaptively partitions a time series into an unknown number of approximately stationary segments, where some spectral…

Methodology · Statistics 2017-06-28 Zeda Li , Robert T. Krafty

DNA methylation datasets in cancer studies are comprised of measurements on a large number of genomic locations called cytosine-phosphate-guanine (CpG) sites with complex correlation structures. A fundamental goal of these studies is the…

Methodology · Statistics 2023-05-05 Chiyu Gu , Veerabhadran Baladandayuthapani , Subharup Guha

Gaussian graphical models (GGMs) are well-established tools for probabilistic exploration of dependence structures using precision matrices. We develop a Bayesian method to incorporate covariate information in this GGMs setup in a nonlinear…

Gaussian graphical models provide a powerful framework to reveal the conditional dependency structure between multivariate variables. The process of uncovering the conditional dependency network is known as structure learning. Bayesian…

Methodology · Statistics 2024-07-30 Lucas Vogels , Reza Mohammadi , Marit Schoonhoven , S. Ilker Birbil

To detect differences between the mean curves of two samples in longitudinal study or functional data analysis, we usually need to partition the temporal or spatial domain into several pre-determined sub-areas. In this paper we apply the…

Methodology · Statistics 2015-05-01 Peirong Xu , Youngjo Lee , Jian Qing Shi

Multivariate categorical data are common in many fields. We are motivated by election polls studies assessing evidence of changes in voters opinions with their candidates preferences in the 2016 United States Presidential primaries or…

Methodology · Statistics 2017-08-10 Massimiliano Russo , Daniele Durante , Bruno Scarpa

The analysis of multivariate functional curves has the potential to yield important scientific discoveries in domains such as healthcare, medicine, economics and social sciences. However, it is common for real-world settings to present…

Methodology · Statistics 2024-07-23 Tui Nolan , Sylvia Richardson , Hélène Ruffieux

For any stream of time-stamped edges that form a dynamic network, an important choice is the aggregation granularity that an analyst uses to bin the data. Picking such a windowing of the data is often done by hand, or left up to the…

Social and Information Networks · Computer Science 2017-02-28 Benjamin Fish , Rajmonda S. Caceres

Commonly, clinical trials report effects not only for the full study population but also for patient subgroups. Meta-analyses of subgroup-specific effects and treatment-by-subgroup interactions may be inconsistent, especially when trials…

Methodology · Statistics 2025-12-23 Renato Panaro , Christian Röver , Tim Friede

We consider the problem of estimating the difference between two functional undirected graphical models with shared structures. In many applications, data are naturally regarded as high-dimensional random function vectors rather than…

Machine Learning · Statistics 2019-11-19 Boxin Zhao , Y. Samuel Wang , Mladen Kolar

The problem of validating or criticising models for georeferenced data is challenging, since the conclusions can vary significantly depending on the locations of the validation set. This work proposes the use of cross-validation techniques…

Computation · Statistics 2018-02-19 Viviana G R Lobo , Thaís C O da Fonseca , Fernando A S Moura

Sparse functional data frequently arise in real-world applications, posing significant challenges for accurate classification. To address this, we propose a novel classification method that integrates functional principal component analysis…

Computation · Statistics 2025-03-17 Ahmad Talafha

Rapid advancements in collection and dissemination of multi-platform molecular and genomics data has resulted in enormous opportunities to aggregate such data in order to understand, prevent, and treat human diseases. While significant…

In this paper, we study the Bayesian multi-task variable selection problem, where the goal is to select activated variables for multiple related data sets simultaneously. Our proposed method generalizes the spike-and-slab prior to multiple…

Methodology · Statistics 2023-08-15 Guanxun Li , Quan Zhou

Regression models are used in a wide range of applications providing a powerful scientific tool for researchers from different fields. Linear, or simple parametric, models are often not sufficient to describe complex relationships between…

Machine Learning · Statistics 2021-11-24 Aliaksandr Hubin , Geir Storvik , Florian Frommlet

In relational DBMS, window functions have been widely used to facilitate data analytics. Surprisingly, while similar concepts have been employed for graph analytics, there has been no explicit notions of graph window analytic functions. In…

Databases · Computer Science 2015-10-27 Qi Fan , Zhengkui Wang , Chee-Yong Chan , Kian-Lee Tan

We present a Bayesian approach to probabilistically infer vertical activity profiles within a radioactive waste drum from segmented gamma scanning (SGS) measurements. Our approach resorts to Markov chain Monte Carlo (MCMC) sampling using…

Data Analysis, Statistics and Probability · Physics 2021-03-30 Eric Laloy , Bart Rogiers , An Bielen , Sven Boden

We propose a novel Bayesian inference framework for distributed differentially private linear regression. We consider a distributed setting where multiple parties hold parts of the data and share certain summary statistics of their portions…

Machine Learning · Statistics 2023-06-08 Barış Alparslan , Sinan Yıldırım , Ş. İlker Birbil