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The study of hierarchy in networks of the human brain has been of significant interest among the researchers as numerous studies have pointed out towards a functional hierarchical organization of the human brain. This paper provides a novel…

Neurons and Cognition · Quantitative Biology 2021-03-02 Dushyant Sahoo , Theodore D. Satterthwaite , Christos Davatzikos

We study possible relations between the structure of the connectome, white matter connecting different regions of brain, and Alzheimer disease. Regression models in covariates including age, gender and disease status for the extent of white…

Methodology · Statistics 2021-04-22 Arkaprava Roy , Subhashis Ghosal , Jeffrey Prescott , Kingshuk Roy Choudhury

Recent studies on analyzing dynamic brain connectivity rely on sliding-window analysis or time-varying coefficient models which are unable to capture both smooth and abrupt changes simultaneously. Emerging evidence suggests state-related…

Applications · Statistics 2019-07-04 Chee-Ming Ting , Hernando Ombao , S. Balqis Samdin , Sh-Hussain Salleh

Statistical modeling of fMRI data is challenging as the data are both spatially and temporally correlated. Spatially, measurements are taken at thousands of contiguous regions, called voxels, and temporally measurements are taken at…

Computation · Statistics 2017-10-05 Ming Teng , Farouk S. Nathoo , Timothy D. Johnson

We propose a novel technique to assess functional brain connectivity in EEG/MEG signals. Our method, called Sparsely-Connected Sources Analysis (SCSA), can overcome the problem of volume conduction by modeling neural data innovatively with…

Methodology · Statistics 2010-08-05 Stefan Haufe , Ryota Tomioka , Guido Nolte , Klaus-Robert Mueller , Motoaki Kawanabe

We propose a Bayesian framework for uncertainty quantification and comparison in brain connectivity graph analysis. Standard graph-based approaches typically rely on point estimates of correlation matrices, overlooking the uncertainty…

Methodology · Statistics 2026-05-29 Alice Chevaux , Julyan Arbel , Guillaume Kon Kam King , Sophie Achard

Brain networks from functional MRI have advanced our understanding of cortical activity and its disruption in neurodegenerative disorders. Recent work has increasingly focused on dynamic (time-varying) brain networks that capture both…

Neurons and Cognition · Quantitative Biology 2026-04-14 Nicolas Rubido , Venia Batziou , Marwan Fuad , Vesna Vuksanovic

Evaluating the functional relationships between brain regions measured with neuroimaging provides insight into how the brain is sharing information at a macro scale. Many functional connectivity methods have been developed for dynamic…

Applications · Statistics 2015-10-30 David B. Keator , Alexander Ihler

The estimation of causal network architectures in the brain is fundamental for understanding cognitive information processes. However, access to the dynamic processes underlying cognition is limited to indirect measurements of the hidden…

Neurons and Cognition · Quantitative Biology 2020-08-17 H. C. Ruiz-Euler , H. J. Kappen

Most approaches to the estimation of brain functional connectivity from the functional magnetic resonance imaging (fMRI) data rely on computing some measure of statistical dependence, or more generally, a distance between univariate…

Computer Vision and Pattern Recognition · Computer Science 2022-09-26 Oleg Kachan , Alexander Bernstein

Functional connections in the brain are frequently represented by weighted networks, with nodes representing locations in the brain, and edges representing the strength of connectivity between these locations. One challenge in analyzing…

Applications · Statistics 2022-09-28 Yura Kim , Daniel Kessler , Elizaveta Levina

Covariance matrix outcomes arise naturally in neuroimaging experiments to study brain functional connectivity. It is also of interest to understand how brain network organization varies with subject-level covariates. Existing covariance…

Methodology · Statistics 2026-05-08 Michelle Murphy Green , Xi Luo , Brian S. Caffo , Yi Zhao

Understanding the complex neural activity dynamics is crucial for the development of the field of neuroscience. Although current functional MRI classification approaches tend to be based on static functional connectivity or cannot capture…

Machine Learning · Computer Science 2025-08-20 Amirali Arbab , Zeinab Davarani , Mehran Safayani

Clinical neuroimaging has recently witnessed explosive growth in data availability which brings studying heterogeneity in clinical cohorts to the spotlight. Normative modeling is an emerging statistical tool for achieving this objective.…

Functional magnetic resonance imaging (fMRI) enables indirect detection of brain activity changes via the blood-oxygen-level-dependent (BOLD) signal. Conventional analysis methods mainly rely on the real-valued magnitude of these signals.…

Methodology · Statistics 2023-10-31 Zhengxin Wang , Daniel B. Rowe , Xinyi Li , D. Andrew Brown

Brain structural connectivity, capturing the white matter fiber tracts among brain regions inferred by diffusion MRI (dMRI), provides a unique characterization of brain anatomical organization. One fundamental question to address with…

Neurons and Cognition · Quantitative Biology 2023-04-05 Selena Wang , Yiting Wang , Frederick H. Xu , Li Shen , Yize Zhao

Autism Spectrum Disorder (ASD) is a pervasive developmental disorder of the central nervous system, primarily manifesting in childhood. It is characterized by atypical and repetitive behaviors. Currently, diagnostic methods mainly rely on…

Neurons and Cognition · Quantitative Biology 2025-03-21 Yiqian Luo , Qiurong Chen , Fali Li , Liang Yi , Peng Xu , Yangsong Zhang

There is increasing interest in learning how human brain networks vary as a function of a continuous trait, but flexible and efficient procedures to accomplish this goal are limited. We develop a Bayesian semiparametric model, which…

Methodology · Statistics 2017-02-02 Lu Wang , Daniele Durante , Rex E. Jung , David B. Dunson

Inferring a binary connectivity graph from resting-state fMRI data for a single subject requires making several methodological choices and assumptions that can significantly affect the results. In this study, we investigate the robustness…

Methodology · Statistics 2025-03-20 Alice Chevaux , Ali Fahkar , Kévin Polisano , Irène Gannaz , Sophie Achard

A Covariance-on-Covariance regression model is introduced in this manuscript. It is assumed that there exists (at least) a pair of linear projections on outcome covariance matrices and predictor covariance matrices such that a log-linear…

Methodology · Statistics 2022-12-21 Yi Zhao , Yize Zhao